PDB: 342 resultsInfo pagesStatus searchChemie searchBIRD

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5IBP	Caspase 3 V266M Descriptor: ACE-ASP-GLU-VAL-ASK, AZIDE ION, Caspase-3 Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-22 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.38 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IAJ	Caspase 3 V266L Descriptor: ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IAG	Caspase 3 V266Q Descriptor: ACE-ASP-GLU-VAL-ASK, ASP-ASP-ASP-MET, Caspase-3 Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
5IAK	Caspase 3 V266S Descriptor: ACE-ASP-GLU-VAL-ASK, Caspase-3, SODIUM ION Authors: Maciag, J.J, Mackenzie, S.H, Tucker, M.B, Schipper, J.L, Swartz, P.D, Clark, A.C. Deposit date: 2016-02-21 Release date: 2016-10-26 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc.Natl.Acad.Sci.USA, 113, 2016
4JJE	Caspase-3 specific unnatural amino acid peptides Descriptor: Caspase inhibitor, Caspase-3 Authors: Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W. Deposit date: 2013-03-07 Release date: 2013-06-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.481 Å) Cite: Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. Acs Chem.Biol., 8, 2013
4JQZ	Human procaspase-3, crystal form 2 Descriptor: Procaspase-3 Authors: Thomsen, N.D, Wells, J.A. Deposit date: 2013-03-20 Release date: 2013-05-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.889 Å) Cite: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4JJ7	Caspase-3 specific unnatural amino acid-based peptides Descriptor: Caspase inhibitor, Caspase-8, DITHIANE DIOL Authors: Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W. Deposit date: 2013-03-07 Release date: 2013-06-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.178 Å) Cite: Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. Acs Chem.Biol., 8, 2013
4JR2	Human procaspase-7/caspase-7 heterodimer bound to Ac-DEVD-CMK Descriptor: Ac-DEVD-CMK, CHLORIDE ION, Procaspase-7 Authors: Thomsen, N.D, Wells, J.A. Deposit date: 2013-03-20 Release date: 2013-05-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4JQY	Human procaspase-3, crystal form 1 Descriptor: Procaspase-3 Authors: Thomsen, N.D, Wells, J.A. Deposit date: 2013-03-20 Release date: 2013-05-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.495 Å) Cite: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4LSZ	Caspase-7 in Complex with DARPin D7.18 Descriptor: Caspase-7 subunit p10, Caspase-7 subunit p20, DARPin D7.18 Authors: Fluetsch, A, Lukarska, M, Gruetter, M.G. Deposit date: 2013-07-23 Release date: 2014-07-02 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Combined inhibition of caspase 3 and caspase 7 by two highly selective DARPins slows down cellular demise. Biochem.J., 461, 2014
4JR1	Human procaspase-7 bound to Ac-DEVD-CMK Descriptor: Ac-DEVD-CMK, CHLORIDE ION, Procaspase-7 Authors: Thomsen, N.D, Wells, J.A. Deposit date: 2013-03-20 Release date: 2013-05-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.149 Å) Cite: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4JB8	Caspase-7 in Complex with DARPin C7_16 Descriptor: Caspase-7 subunit p11, Caspase-7 subunit p20, DARPin C7_16 Authors: Fluetsch, A, Seeger, M.A, Gruetter, M.G. Deposit date: 2013-02-19 Release date: 2013-08-21 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Design, construction, and characterization of a second-generation DARPin library with reduced hydrophobicity. Protein Sci., 22, 2013
4M9R	Crystal structure of CED-3 Descriptor: Cell death protein 3 Authors: Xu, Y, Jeffrey, P.D, Shi, Y.G. Deposit date: 2013-08-15 Release date: 2013-10-09 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.656 Å) Cite: Mechanistic insights into CED-4-mediated activation of CED-3 Genes Dev., 27, 2013
4JR0	Human procaspase-3 bound to Ac-DEVD-CMK Descriptor: Ac-DEVD-CMK, CHLORIDE ION, Procaspase-3 Authors: Thomsen, N.D, Wells, J.A. Deposit date: 2013-03-20 Release date: 2013-05-08 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.796 Å) Cite: Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4JJ8	Caspase-3 specific unnatural amino acid peptides Descriptor: Caspase Inhibitor, Caspase-7 Authors: Vickers, C.J, Gonzalez-Paez, G.E, Wolan, D.W. Deposit date: 2013-03-07 Release date: 2013-06-12 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.937 Å) Cite: Selective Detection of Caspase-3 versus Caspase-7 Using Activity-Based Probes with Key Unnatural Amino Acids. Acs Chem.Biol., 8, 2013
4N7M	Tailoring Small Molecules for an Allosteric Site on Procaspase-6 Descriptor: 3-(pyrrolidin-1-yl)isoquinolin-1(2H)-one, Caspase-6, PHOSPHATE ION Authors: Murray, J.M, Steffek, M. Deposit date: 2013-10-15 Release date: 2013-12-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.125 Å) Cite: Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
4N6G	Tailoring Small Molecules for an Allosteric Site on Procaspase-6 Descriptor: 3-(pyrrolidin-1-yl)isoquinolin-1(2H)-one, Caspase-6, PHOSPHATE ION Authors: Murray, J.M, Steffek, M. Deposit date: 2013-10-11 Release date: 2014-01-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.142 Å) Cite: Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
4NBK	Tailoring Small Molecules for an Allosteric Site on Procaspase-6 Descriptor: 2-{[(3-methylpyridin-2-yl)amino]methyl}phenol, Caspase-6, PHOSPHATE ION Authors: Murray, J.M, Steffek, M. Deposit date: 2013-10-23 Release date: 2014-01-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.936 Å) Cite: Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
4N7J	Tailoring Small Molecules for an Allosteric Site on Procaspase-6 Descriptor: 3-(pyrrolidin-1-yl)isoquinolin-1(2H)-one, Caspase-6, PHOSPHATE ION Authors: Murray, J.M, Steffek, M. Deposit date: 2013-10-15 Release date: 2013-12-18 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.673 Å) Cite: Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
4NBL	Tailoring Small Molecules for an Allosteric Site on Procaspase-6 Descriptor: 5-fluoro-2-({[3-(pyrimidin-2-yl)pyridin-2-yl]amino}methyl)phenol, Caspase-6, PHOSPHATE ION Authors: Murray, J.M, Steffek, M. Deposit date: 2013-10-23 Release date: 2014-01-01 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.756 Å) Cite: Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem, 9, 2014
3P4U	Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor Descriptor: Ac-VEID-CHO inhibitor, Caspase-6 Authors: Mueller, I, Lamers, M.B.A.C, Ritchie, A.J, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. Deposit date: 2010-10-07 Release date: 2011-09-28 Last modified: 2015-12-02 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of active and inhibitor-bound human Casp6 To be Published
3P45	Crystal structure of apo-caspase-6 at physiological pH Descriptor: caspase-6 Authors: Mueller, I, Lamers, M.B.A.C, Ritchie, A.J, Dominguez, C, Munoz, I, Maillard, M, Kiselyov, A. Deposit date: 2010-10-06 Release date: 2011-06-15 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Crystal structures of active and inhibitor-bound human Casp6 To be Published
3R6L	Caspase-2 T380A bound with Ac-VDVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)VDVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-21 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R7B	Caspase-2 bound to one copy of Ac-DVAD-CHO Descriptor: Caspase-2 subunit p12, Caspase-2 subunit p18, Peptide Inhibitor (ACE)DVAD-CHO Authors: Tang, Y, Wells, J, Arkin, M. Deposit date: 2011-03-22 Release date: 2011-07-27 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J.Biol.Chem., 286, 2011
3R5K	A designed redox-controlled caspase-7 Descriptor: Caspase-7, FORMIC ACID Authors: Witkowski, W.A, Hardy, J.A. Deposit date: 2011-03-18 Release date: 2011-06-29 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.86 Å) Cite: A designed redox-controlled caspase. Protein Sci., 20, 2011

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