4EJF

Allosteric peptides that bind to a caspase zymogen and mediate caspase tetramerization

Summary for 4EJF

• Entry DOI: 10.2210/pdb4ejf/pdb
• Descriptor: Caspase-6, phage-derived peptide 419, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: caspase-6, zymogen, c163a, caspase, protease, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P55212
• Total number of polymer chains: 8
• Total formula weight: 137342.77

Authors

Murray, J.M. (deposition date: 2012-04-06, release date: 2012-06-20, Last modification date: 2023-09-13)

• Primary citation: Stanger, K.,Steffek, M.,Zhou, L.,Pozniak, C.D.,Quan, C.,Franke, Y.,Tom, J.,Tam, C.,Elliott, J.M.,Lewcock, J.W.,Zhang, Y.,Murray, J.,Hannoush, R.N.; Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.; Nat.Chem.Biol., 8:655-660, 2012; PubMed: 22683611; DOI: 10.1038/nchembio.967

Experimental method

X-RAY DIFFRACTION (2.6465 Å)