4EJF
Allosteric peptides that bind to a caspase zymogen and mediate caspase tetramerization
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Caspase-6 | polymer | 279 | 32055.6 | 4 | UniProt (P55212) Pfam (PF00656) In PDB | Homo sapiens (human) | CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11 |
2 | E, F, G, H | phage-derived peptide 419 | polymer | 18 | 2232.6 | 4 | synthetic | ||
3 | C, D | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
4 | water | water | 18.0 | 279 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 293 (UniProt: P55212)
PDB | External Database | Details |
---|---|---|
Met 21 | - | expression tag |
Gly 22 | - | expression tag |
Ser 23 | - | expression tag |
Ala 163 | Cys 163 | engineered mutation |
His 294 | - | expression tag |
His 295 | - | expression tag |
His 296 | - | expression tag |
His 297 | - | expression tag |
His 298 | - | expression tag |
His 299 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 137152.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 189.9 | |
All* | Total formula weight | 137342.8 |