4EJF

Allosteric peptides that bind to a caspase zymogen and mediate caspase tetramerization

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Caspase-6	polymer	279	32055.6	4	UniProt (P55212) Pfam (PF00656)	Homo sapiens (human)	CASP-6, Apoptotic protease Mch-2, Caspase-6 subunit p18, Caspase-6 subunit p11
2	E, F, G, H (E, F, G, H)	phage-derived peptide 419	polymer	18	2232.6	4		synthetic
3	I, J (C, D)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	279	Chemie (HOH)

Sequence modifications

A, B, C, D: 24 - 293 (UniProt: P55212)

PDB	External Database	Details
Met 21	-	expression tag
Gly 22	-	expression tag
Ser 23	-	expression tag
Ala 163	Cys 163	engineered mutation
His 294	-	expression tag
His 295	-	expression tag
His 296	-	expression tag
His 297	-	expression tag
His 298	-	expression tag
His 299	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	137152.8
Non-Polymers*	Number of molecules	2
	Total formula weight	189.9
All*	Total formula weight	137342.8

*Water molecules are not included.