5IC6

Crystal structure of caspase-7 DEVE peptide complex

Summary for 5IC6

Related5IC4
DescriptorCaspase-7 subunit p20, Caspase-7 subunit p11, DEVE peptide (3 entities in total)
Functional Keywordsapoptosis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm P55210 P55210
Total number of polymer chains6
Total molecular weight71802.98
Authors
Seaman, J.E.,Julien, O.,Lee, P.S.,Rettenmaier, T.J.,Thomsen, N.D.,Wells, J.A. (deposition date: 2016-02-22, release date: 2016-07-20, Last modification date: 2016-10-05)
Primary citation
Seaman, J.E.,Julien, O.,Lee, P.S.,Rettenmaier, T.J.,Thomsen, N.D.,Wells, J.A.
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues.
Cell Death Differ., 23:1717-1726, 2016
PubMed: 27367566 (PDB entries with the same primary citation)
DOI: 10.1038/cdd.2016.62
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.247400.2%1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution