PDB: 4080 resultsInfo pagesStatus searchChemie searchBIRD

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4JK6	Human urokinase-type Plasminogen Activator (uPA) in complex with a bicyclic peptide inhibitor (UK18-D-Aba) Descriptor: 1,3,5-tris(bromomethyl)benzene, CHLORIDE ION, HEXAETHYLENE GLYCOL, ... Authors: Buth, S.A, Leiman, P.G, Chen, S, Heinis, C. Deposit date: 2013-03-09 Release date: 2013-07-17 Last modified: 2024-07-10 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Improving binding affinity and stability of Peptide ligands by substituting glycines with d-amino acids. Chembiochem, 14, 2013
4E7R	Thrombin in complex with 3-amidinophenylalanine inhibitor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-{[(2',4'-dichlorobiphenyl-3-yl)sulfonyl]amino}-3-oxopropyl]benzenecarboximidamide, GLYCEROL, ... Authors: Ruehmann, E, Heine, A, Klebe, G. Deposit date: 2012-03-19 Release date: 2012-06-20 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.25 Å) Cite: New 3-amidinophenylalanine-derived inhibitors of matriptase MEDCHEMCOMM, 3, 2012
4EST	CRYSTAL STRUCTURE OF THE COVALENT COMPLEX FORMED BY A PEPTIDYL ALPHA,ALPHA-DIFLUORO-BETA-KETO AMIDE WITH PORCINE PANCREATIC ELASTASE AT 1.78-ANGSTROMS RESOLUTION Descriptor: CALCIUM ION, ELASTASE, INHIBITOR ACE-ALA-PRO-VAI-DIFLUORO-N-PHENYLETHYLACETAMIDE, ... Authors: Takahashi, L.H, Radhakrishnan, R, Rosenfieldjunior, R.E, Meyerjunior, E.F, Trainor, D.A. Deposit date: 1989-05-15 Release date: 1992-04-15 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Crystal Structure of the Covalent Complex Formed by a Peptidyl Alpha,Alpha-Difluoro-Beta-Keto Amide with Porcine Pancreatic Elastase at 1.78-Angstroms Resolution J.Am.Chem.Soc., 111, 1989
4E7N	Crystal Structure of AhV_TL-I, a Glycosylated Snake-venom Thrombin-like Enzyme from Agkistrodon halys Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Snake-venom Thrombin-like Enzyme Authors: Zeng, F, Li, X, Teng, M, Niu, L. Deposit date: 2012-03-18 Release date: 2012-04-04 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Crystal Structure of AhV_TL-I, a Glycosylated Snake-venom Thrombin-like Enzyme from Agkistrodon halys to be published
6BJR	Crystal structure of prothrombin mutant S101C/A470C Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, Prothrombin, ... Authors: Chinnaraj, M, Chen, Z, Pelc, L, Grese, Z, Bystranowska, D, Di Cera, E, Pozzi, N. Deposit date: 2017-11-06 Release date: 2018-06-27 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (6 Å) Cite: Structure of prothrombin in the closed form reveals new details on the mechanism of activation. Sci Rep, 8, 2018
6CYM	Reversible Covalent Direct Thrombin Inhibitors Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxybenzoic acid, Prothrombin, ... Authors: Sivaraja, M, Williams, D.C. Deposit date: 2018-04-06 Release date: 2018-05-09 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Reversible covalent direct thrombin inhibitors. PLoS ONE, 13, 2018
4FUF	Crystal Structure of the Urokinase Descriptor: 8-(3-bromopropoxy)-7-methoxynaphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Urokinase to be published
4FUJ	Crystal Structure of the Urokinase Descriptor: 6-{(E)-2-[3-(2-hydroxyethyl)phenyl]ethenyl}naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of the Urokinase TO BE PUBLISHED
4GAW	Crystal structure of active human granzyme H Descriptor: CHLORIDE ION, Granzyme H, SULFATE ION Authors: Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. Deposit date: 2012-07-25 Release date: 2013-01-16 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3 Å) Cite: Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
4FUC	Crystal Structure of the Urokinase Descriptor: 6-[(Z)-AMINO(IMINO)METHYL]-N-[4-(AMINOMETHYL)PHENYL]-2-NAPHTHAMIDE, ACETATE ION, GLYCEROL, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.72 Å) Cite: Crystal Structure of the Urokinase to be published
4FUD	Crystal Structure of the Urokinase Descriptor: 8-aminonaphthalene-2-carboximidamide, SODIUM ION, SUCCINIC ACID, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Urokinase to be published
4FU8	Crystal Structure of the Urokinase Descriptor: ACETATE ION, SUCCINIC ACID, SULFATE ION, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the Urokinase to be published
4FUI	Crystal Structure of the Urokinase Descriptor: 7-METHOXY-8-[1-(METHYLSULFONYL)-1H-PYRAZOL-4-YL]NAPHTHALENE-2-CARBOXIMIDAMIDE, GLYCEROL, SODIUM ION, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Urokinase to be published
4DII	X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of potassium ions Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. Deposit date: 2012-01-31 Release date: 2012-07-18 Last modified: 2024-10-30 Method: X-RAY DIFFRACTION (2.05 Å) Cite: High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity. Nucleic Acids Res., 40, 2012
4DW2	The crystal structure of uPA in complex with the Fab fragment of mAb-112 Descriptor: Fab fragment of pro-uPA antibody mAb-112, SULFATE ION, Urokinase-type plasminogen activator Authors: Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. Deposit date: 2012-02-24 Release date: 2013-01-16 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.97 Å) Cite: Rezymogenation of active urokinase induced by an inhibitory antibody. Biochem.J., 449, 2013
4FUG	Crystal Structure of the Urokinase Descriptor: ACETATE ION, GLYCEROL, SULFATE ION, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal Structure of the Urokinase to be published
4FU7	Crystal Structure of the Urokinase Descriptor: 2-[(7-carbamimidoyl-2-methoxynaphthalen-1-yl)oxy]acetamide, ACETATE ION, SULFATE ION, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Urokinase to be published
4FUE	Crystal Structure of the Urokinase Descriptor: 6-(1,2,3,4-tetrahydroisoquinolin-6-ylethynyl)naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the Urokinase to be published
6C0S	Factor XIA in complex with the inhibitor methyl (4-{6-[(1S)-2-[(3R)-1-acetylpiperidin-3-yl]-1-({(2E)-3-[5-chloro-2- (1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl) carbamate Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ... Authors: Sheriff, S. Deposit date: 2018-01-02 Release date: 2018-03-07 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.35 Å) Cite: Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. Bioorg. Med. Chem. Lett., 28, 2018
4GSO	structure of Jararacussin-I Descriptor: Thrombin-like enzyme BjussuSP-1 Authors: Ullah, A, Souza, T.C.A.B, Zanphorlin, L.M, Mariutti, R, Sanata, S.V, Murakami, M.T, Arni, R.K. Deposit date: 2012-08-28 Release date: 2012-12-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Crystal structure of Jararacussin-I: The highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes. Protein Sci., 22, 2013
4DIH	X-ray structure of the complex between human alpha thrombin and thrombin binding aptamer in the presence of sodium ions Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... Authors: Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. Deposit date: 2012-01-31 Release date: 2012-07-18 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity. Nucleic Acids Res., 40, 2012
4DVA	The crystal structure of human urokinase-type plasminogen activator catalytic domain Descriptor: HEXAETHYLENE GLYCOL, SULFATE ION, Urokinase-type plasminogen activator Authors: Jiang, L, Botkjaer, K.A, Andersen, L.M, Yuan, C, Andreasen, P.A, Huang, M. Deposit date: 2012-02-23 Release date: 2013-01-16 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Rezymogenation of active urokinase induced by an inhibitory antibody Biochem.J., 449, 2013
4E05	Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Salivary anti-thrombin peptide anophelin, ... Authors: Figueiredo, A.C, de Sanctis, D, Gutierrez-Gallego, R, Cereija, T.B, Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B. Deposit date: 2012-03-02 Release date: 2012-12-05 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.304 Å) Cite: Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proc.Natl.Acad.Sci.USA, 109, 2012
4E06	Anophelin from the malaria vector inhibits thrombin through a novel reverse-binding mechanism Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, Salivary anti-thrombin peptide anophelin, ... Authors: Figueiredo, A.C, de Sanctis, D, Gutierrez-Gallego, R, Cereija, T.B, Macedo-Ribeiro, S, Fuentes-Prior, P, Pereira, P.J.B. Deposit date: 2012-03-02 Release date: 2012-12-05 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (3.196 Å) Cite: Unique thrombin inhibition mechanism by anophelin, an anticoagulant from the malaria vector. Proc.Natl.Acad.Sci.USA, 109, 2012
4FUH	Crystal Structure of the Urokinase Descriptor: 6-[(phenylcarbamoyl)amino]naphthalene-2-carboximidamide, ACETATE ION, GLYCEROL, ... Authors: Kang, Y.N, Stuckey, J.A, Nienaber, V, Giranda, V. Deposit date: 2012-06-28 Release date: 2012-08-22 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Crystal Structure of the Urokinase to be published

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