4E7R

Thrombin in complex with 3-amidinophenylalanine inhibitor

Summary for 4E7R

• Entry DOI: 10.2210/pdb4e7r/pdb
• Related: 3F68 3QWC 3QX5
• Descriptor: Thrombin light chain, Thrombin heavy chain, Hirudin variant-2, ... (9 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, serine protease, kringle, hydrolase, blood coagulation, blood clotting, convertion of fibrinogen to fibrin, blood clotting inhibitor, thrombin inhibitor, glycosylation, blood, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 72942.31

Authors

Ruehmann, E.,Heine, A.,Klebe, G. (deposition date: 2012-03-19, release date: 2012-06-20, Last modification date: 2023-12-06)

• Primary citation: Hammami, M.,Ruehmann, E.,Mauerer, M.,Heine, A.,Guetschow, M.,Klebe, G.,Steinmetzer, T.; New 3-amidinophenylalanine-derived inhibitors of matriptase; MEDCHEMCOMM, 3:807-813, 2012; DOI: 10.1039/C2MD20074K

Experimental method

X-RAY DIFFRACTION (2.25 Å)