3F68
Thrombin Inhibition
Summary for 3F68
Entry DOI | 10.2210/pdb3f68/pdb |
Related | 1K22 2ZC9 2ZDA 2ZFP 2ZGX 3DUX |
Related PRD ID | PRD_000611 |
Descriptor | Prothrombin, Hirudin variant-2, N-acetyl-3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide, ... (6 entities in total) |
Functional Keywords | blood clotting, hydrolase inhibitor, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 35777.15 |
Authors | |
Primary citation | Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J.Mol.Biol., 391:552-564, 2009 Cited by PubMed: 19520086DOI: 10.1016/j.jmb.2009.06.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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