3F68

Thrombin Inhibition

Summary for 3F68

Entry DOI	10.2210/pdb3f68/pdb
Related	1K22 2ZC9 2ZDA 2ZFP 2ZGX 3DUX
Related PRD ID	PRD_000611
Descriptor	Prothrombin, Hirudin variant-2, N-acetyl-3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide, ... (6 entities in total)
Functional Keywords	blood clotting, hydrolase inhibitor, acute phase, blood coagulation, gamma-carboxyglutamic acid, glycoprotein, hydrolase, kringle, protease, secreted, serine protease, protease inhibitor, serine protease inhibitor, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	35777.15
Authors	Baum, B.,Heine, A.,Klebe, G. (deposition date: 2008-11-05, release date: 2009-10-20, Last modification date: 2023-11-15)
Primary citation	Baum, B.,Muley, L.,Heine, A.,Smolinski, M.,Hangauer, D.,Klebe, G. Think twice: understanding the high potency of bis(phenyl)methane inhibitors of thrombin. J.Mol.Biol., 391:552-564, 2009 Cited by PubMed: 19520086 DOI: 10.1016/j.jmb.2009.06.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.75 Å)

Structure validation