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7YSV	GluK1-1a extracellular domain captured in SYM2081 bound desensitized state Descriptor: Glutamate receptor Authors: Dhingra, S, Kumar, J. Deposit date: 2022-08-13 Release date: 2023-08-16 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (8.01 Å) Cite: Functional Implications of the Exon 9 Splice Insert in GluK1 Kainate Receptors Elife, 2023
7YSJ	GluK1-1a in nanodisc captured in SYM2081 bound desensitized state Descriptor: Glutamate receptor Authors: Dhingra, S, Kumar, J. Deposit date: 2022-08-12 Release date: 2023-08-16 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (5.2 Å) Cite: Functional Implications of the Exon 9 Splice Insert in GluK1 Kainate Receptors Elife, 2023
6FQI	GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution Descriptor: GLUTAMIC ACID, Glutamate receptor 2 Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.91001153 Å) Cite: Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
6FQK	GluA2(flop) S729C ligand binding core dimer bound to ZK200775 at 1.98 Angstrom resolution Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (1.98010445 Å) Cite: Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
6FQJ	GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.500017 Å) Cite: Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
6FQG	GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form A) at 2.34 Angstrom resolution Descriptor: GLUTAMIC ACID, Glutamate receptor 2 Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.34139085 Å) Cite: X-ray structure of GluA2 flop G724C ligand binding core dimer bound to glutamate at 2.32 Angstroms resolution To Be Published
1P1N	GluR2 Ligand Binding Core (S1S2J) Mutant L650T in Complex with Kainate Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2 Authors: Armstrong, N, Mayer, M.L, Gouaux, E. Deposit date: 2003-04-13 Release date: 2003-06-10 Last modified: 2021-10-27 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Tuning activation of the AMPA-sensitive GluR2 ion channel by genetic adjustment of agonist-induced conformational changes. Proc.Natl.Acad.Sci.USA, 100, 2003
1PB8	CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-SERINE AT 1.45 ANGSTROMS RESOLUTION Descriptor: D-SERINE, N-methyl-D-aspartate Receptor Subunit 1 Authors: Furukawa, H, Gouaux, E. Deposit date: 2003-05-14 Release date: 2003-06-24 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core Embo J., 22, 2003
1PB9	CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH D-CYCLOSERINE AT 1.60 ANGSTROMS RESOLUTION Descriptor: (R)-4-AMINO-ISOXAZOLIDIN-3-ONE, N-methyl-D-aspartate Receptor Subunit 1 Authors: Furukawa, H, Gouaux, E. Deposit date: 2003-05-14 Release date: 2003-06-24 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core Embo J., 22, 2003
1PBQ	CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH 5,7-DICHLOROKYNURENIC ACID (DCKA) AT 1.90 ANGSTROMS RESOLUTION Descriptor: 5,7-DICHLORO-4-HYDROXYQUINOLINE-2-CARBOXYLIC ACID, N-methyl-D-aspartate Receptor Subunit 1 Authors: Furukawa, H, Gouaux, E. Deposit date: 2003-05-14 Release date: 2003-07-29 Last modified: 2020-07-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core Embo J., 22, 2003
8SS4	Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 (apo state) Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, Protein cornichon homolog 2, ... Authors: Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS8	Structure of AMPA receptor GluA2 complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS5	Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 (apo state) Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-5 subunit chimera, SODIUM ION Authors: Yen, L.Y, Gangwar, S.P, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (3.56 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SSA	Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.88 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SSB	Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to glutamate and channel blocker spermidine (desensitized state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, GLUTAMIC ACID, Glutamate receptor 2, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (3.66 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS7	Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS3	Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS2	Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK and channel blocker spermidine (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, Digitonin, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.58 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS9	Structure of LBD-TMD of AMPA receptor GluA2 in complex with auxiliary subunit TARP gamma-5 bound to competitive antagonist ZK and antiepileptic drug perampanel (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-10-25 Method: ELECTRON MICROSCOPY (2.72 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
8SS6	Structure of AMPA receptor GluA2 complex with auxiliary subunits TARP gamma-5 and cornichon-2 bound to competitive antagonist ZK, channel blocker spermidine and antiepileptic drug perampanel (closed state) Descriptor: 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile, CHOLESTEROL, ... Authors: Gangwar, S.P, Yen, L.Y, Yelshanskaya, M.V, Sobolevsky, A.I. Deposit date: 2023-05-08 Release date: 2023-09-06 Last modified: 2023-11-01 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Modulation of GluA2-gamma 5 synaptic complex desensitization, polyamine block and antiepileptic perampanel inhibition by auxiliary subunit cornichon-2. Nat.Struct.Mol.Biol., 30, 2023
1PB7	CRYSTAL STRUCTURE OF THE NR1 LIGAND BINDING CORE IN COMPLEX WITH GLYCINE AT 1.35 ANGSTROMS RESOLUTION Descriptor: GLYCINE, N-methyl-D-aspartate Receptor Subunit 1 Authors: Furukawa, H, Gouaux, E. Deposit date: 2003-05-14 Release date: 2003-06-24 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core Embo J., 22, 2003
8JF7	Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Descriptor: GluN1-specific antibody fragment heavy chain, GluN1-specific antibody fragment light chain, GluN2A-specific antibody fragment heavy chain, ... Authors: Kou, Z, Zhu, S. Deposit date: 2023-05-17 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (7.73 Å) Cite: Probing the architecture of native GluN1-N2-N3A NMDA receptors by cryo-EM and click chemistry. To Be Published
2PBW	Crystal Structure of the Ligand-Binding Core of iGluR5 in Complex with the Partial agonist Domoic Acid at 2.5 A Resolution Descriptor: (2S,3S,4S)-2-CARBOXY-4-[(1Z,3E,5R)-5-CARBOXY-1-METHYL-1,3-HEXADIENYL]-3-PYRROLIDINEACETIC ACID, Glutamate receptor, ionotropic kainate 1 Authors: Hald, H, Naur, P, Gajhede, M, Kastrup, J.S. Deposit date: 2007-03-29 Release date: 2007-07-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J.Biol.Chem., 282, 2007
2OJT	Structure and mechanism of kainate receptor modulation by anions Descriptor: (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE, BROMIDE ION, Glutamate receptor, ... Authors: Mayer, M.L. Deposit date: 2007-01-14 Release date: 2007-04-03 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Structure and mechanism of kainate receptor modulation by anions. Neuron, 53, 2007
1NNK	X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions. Descriptor: 3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE, CHLORIDE ION, Glutamate receptor 2, ... Authors: Lunn, M.-L, Hogner, A, Stensbol, T.B, Gouaux, E, Egebjerg, J, Kastrup, J.S. Deposit date: 2003-01-14 Release date: 2003-03-04 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Three-Dimensional Structure of the Ligand-Binding Core of GluR2 in Complex with the Agonist (S)-ATPA: Implications for Receptor Subunit Selectivity. J.Med.Chem., 46, 2003

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