PDB: 533 resultsInfo pagesStatus searchChemie searchBIRD

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5QU7	Crystal Structure of swapped human Nck SH3.1 domain, 1.3A, orthorhombic form III Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5QU4	Crystal Structure of swapped human Nck SH3.1 domain, 1.05A, orthorhombic form I Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.05 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5OAV	High resolution crystal structure of the c-Src-SH3 domain mutant E93V in complex with the high affinity synthetic peptide APP12: monoclinic crystal Descriptor: APP12, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2017-06-23 Release date: 2017-07-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (0.95 Å) Cite: High resolution crystal structure of the c-Src-SH3 domain mutant E93V in complex with the high affinity synthetic peptide APP12: monoclinic crystal to be published
5QU6	Crystal Structure of swapped human Nck SH3.1 domain, 1.8A, triclinic Descriptor: Cytoplasmic protein NCK1 Authors: Rudolph, M.G. Deposit date: 2019-12-13 Release date: 2020-02-12 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.816 Å) Cite: Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295, 2020
5OB2	Crystal structure of the c-Src-SH3 domain E97T mutant in complex with the high affinity peptide APP12 Descriptor: APP12, Proto-oncogene tyrosine-protein kinase Src Authors: Camara-Artigas, A. Deposit date: 2017-06-25 Release date: 2017-07-12 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Crystal structure of the c-Src-SH3 domain E97T mutant in complex with the high affinity peptide APP12 to be published
3THK	Structure of SH3 chimera with a type II ligand linked to the chain C-terminal Descriptor: BETA-MERCAPTOETHANOL, Proline-rich peptide, SULFATE ION, ... Authors: Gabdulkhakov, A.G, Gushchina, L.V, Nikulin, A.D, Nikonov, S.V, Filimonov, V.V. Deposit date: 2011-08-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.7 Å) Cite: High-Resolution Crystal Structure of Spectrin SH3 Domain Fused with a Proline-Rich Peptide. J.Biomol.Struct.Dyn., 29, 2011
3UA6	Crystal Structure of the Human Fyn SH3 domain Descriptor: FORMIC ACID, GLYCEROL, SODIUM ION, ... Authors: Camara-Artigas, A, Martin-Garcia, J.M. Deposit date: 2011-10-21 Release date: 2012-07-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.85 Å) Cite: The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein. Acta Crystallogr.,Sect.D, 68, 2012
5O2M	p130Cas SH3 domain Descriptor: Breast cancer anti-estrogen resistance 1 Authors: Hexnerova, R, Veverka, V. Deposit date: 2017-05-22 Release date: 2017-09-20 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
5O2P	p130Cas SH3 domain PTP-PEST peptide chimera Descriptor: Breast cancer anti-estrogen resistance 1,Tyrosine-protein phosphatase non-receptor type 12 Authors: Hexnerova, R, Veverka, V. Deposit date: 2017-05-22 Release date: 2017-09-20 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
5O2Q	p130Cas SH3 domain Vinculin peptide chimera Descriptor: Breast cancer anti-estrogen resistance 1,Vinculin Authors: Hexnerova, R, Veverka, V. Deposit date: 2017-05-22 Release date: 2017-09-20 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep, 7, 2017
1AWJ	INTRAMOLECULAR ITK-PROLINE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE Descriptor: ITK Authors: Andreotti, A.H, Bunnell, S.C, Feng, S, Berg, L.J, Schreiber, S.L. Deposit date: 1997-10-02 Release date: 1998-01-14 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Regulatory intramolecular association in a tyrosine kinase of the Tec family. Nature, 385, 1997
1AZG	NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE Descriptor: FYN, PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR Authors: Renzoni, D.A, Pugh, D.J.R, Siligardi, G, Das, P, Morton, C.J, Rossi, C, Waterfield, M.D, Campbell, I.D, Ladbury, J.E. Deposit date: 1997-11-18 Release date: 1998-02-25 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. Biochemistry, 35, 1996
1AWW	SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, 42 STRUCTURES Descriptor: BRUTON'S TYROSINE KINASE Authors: Hansson, H, Mattsson, P.T, Allard, P, Haapaniemi, P, Vihinen, M, Smith, C.I.E, Hard, T. Deposit date: 1997-10-06 Release date: 1998-04-08 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the SH3 domain from Bruton's tyrosine kinase. Biochemistry, 37, 1998
1AOJ	THE SH3 DOMAIN OF EPS8 EXISTS AS A NOVEL INTERTWINED DIMER Descriptor: EPS8 Authors: Kishan, K.V.R, Newcomer, M.E. Deposit date: 1997-07-07 Release date: 1998-07-08 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: The SH3 domain of Eps8 exists as a novel intertwined dimer. Nat.Struct.Biol., 4, 1997
1BU1	SRC FAMILY KINASE HCK SH3 DOMAIN Descriptor: PROTEIN (HEMOPOIETIC CELL KINASE) Authors: Arold, S, Franken, P, Dumas, C. Deposit date: 1998-09-09 Release date: 1998-11-11 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.6 Å) Cite: RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef. Biochemistry, 37, 1998
1B07	CRK SH3 DOMAIN COMPLEXED WITH PEPTOID INHIBITOR Descriptor: PHENYLETHANE, PROTEIN (PROTO-ONCOGENE CRK (CRK)), PROTEIN (SH3 PEPTOID INHIBITOR) Authors: Nguyen, J.T, Turck, C.W, Cohen, F.E, Zuckermann, R.N, Lim, W.A. Deposit date: 1998-11-17 Release date: 1999-01-06 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Exploiting the basis of proline recognition by SH3 and WW domains: design of N-substituted inhibitors. Science, 282, 1998
1AWO	THE SOLUTION NMR STRUCTURE OF ABL SH3 AND ITS RELATIONSHIP TO SH2 IN THE SH(32) CONSTRUCT, 20 STRUCTURES Descriptor: ABL TYROSINE KINASE Authors: Cowburn, D. Deposit date: 1997-10-03 Release date: 1998-01-28 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct. Structure, 3, 1995
1CKB	STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK Descriptor: C-CRK N-TERMINAL SH3 DOMAIN, SOS PEPTIDE (PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-ARG) Authors: Wu, X, Kuriyan, J. Deposit date: 1995-01-24 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure, 3, 1995
1CKA	STRUCTURAL BASIS FOR THE SPECIFIC INTERACTION OF LYSINE-CONTAINING PROLINE-RICH PEPTIDES WITH THE N-TERMINAL SH3 DOMAIN OF C-CRK Descriptor: C-CRK N-TERMINAL SH3 DOMAIN, C3G PEPTIDE (PRO-PRO-PRO-ALA-LEU-PRO-PRO-LYS-LYS-ARG) Authors: Wu, X, Kuriyan, J. Deposit date: 1995-01-24 Release date: 1995-05-08 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure, 3, 1995
1E6G	A-SPECTRIN SH3 DOMAIN A11V, V23L, M25I, V53I, V58L MUTANT Descriptor: SPECTRIN ALPHA CHAIN, SULFATE ION Authors: Vega, M.C, Serrano, L. Deposit date: 2000-08-15 Release date: 2002-05-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design Nat.Struct.Biol., 9, 2002
1E7O	A-SPECTRIN SH3 DOMAIN A11V, V23L, M25V, V44I, V58L MUTATIONS Descriptor: GLYCEROL, SPECTRIN ALPHA CHAIN Authors: Vega, M.C, Serrano, L. Deposit date: 2000-08-31 Release date: 2003-05-21 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (3.2 Å) Cite: A Thermodynamic and Kinetic Analysis of the Folding Pathway of an SH3 Domain Entropically Stabilised by a Redesigned Hydrophobic Core J.Mol.Biol., 328, 2003
1BK2	A-SPECTRIN SH3 DOMAIN D48G MUTANT Descriptor: A-SPECTRIN Authors: Martinez, J.C, Pisabarro, M.T, Serrano, L. Deposit date: 1998-07-14 Release date: 1999-02-16 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Obligatory steps in protein folding and the conformational diversity of the transition state. Nat.Struct.Biol., 5, 1998
1E6H	A-SPECTRIN SH3 DOMAIN A11V, M25I, V44I, V58L MUTANTS Descriptor: SPECTRIN ALPHA CHAIN Authors: Vega, M.C, Serrano, L. Deposit date: 2000-08-17 Release date: 2002-05-23 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (2.01 Å) Cite: Conformational Strain in the Hydrophobic Core and its Implications for Protein Folding and Design Nat.Struct.Biol., 9, 2002
1AZE	NMR STRUCTURE OF THE COMPLEX BETWEEN THE C32S-Y7V MUTANT OF THE NSH3 DOMAIN OF GRB2 WITH A PEPTIDE FROM SOS, 10 STRUCTURES Descriptor: GRB2, SOS Authors: Vidal, M, Gincel, E, Goudreau, N, Cornille, F, Parker, F, Duchesne, M, Tocque, B, Garbay, C, Roques, B.P. Deposit date: 1997-11-17 Release date: 1999-05-18 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Molecular and cellular analysis of Grb2 SH3 domain mutants: interaction with Sos and dynamin. J.Mol.Biol., 290, 1999
1AWX	SH3 DOMAIN FROM BRUTON'S TYROSINE KINASE, NMR, MINIMIZED AVERAGE STRUCTURE Descriptor: BRUTON'S TYROSINE KINASE Authors: Hansson, H, Mattsson, P.T, Allard, P, Haapaniemi, P, Vihinen, M, Smith, C.I.E, Hard, T. Deposit date: 1997-10-06 Release date: 1998-04-08 Last modified: 2024-05-22 Method: SOLUTION NMR Cite: Solution structure of the SH3 domain from Bruton's tyrosine kinase. Biochemistry, 37, 1998

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