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5QU7

Crystal Structure of swapped human Nck SH3.1 domain, 1.3A, orthorhombic form III

Summary for 5QU7
Entry DOI10.2210/pdb5qu7/pdb
Group depositionstructural plasticity of the Nck1-SH3.1 domain (G_1002110)
DescriptorCytoplasmic protein NCK1 (2 entities in total)
Functional Keywordssh3 domain, adaptor, peptide binding, signaling protein, domain swap
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight19533.68
Authors
Rudolph, M.G. (deposition date: 2019-12-13, release date: 2020-02-12, Last modification date: 2024-03-06)
Primary citationRichter, K.,Rufer, A.C.,Muller, M.,Burger, D.,Casagrande, F.,Grossenbacher, T.,Huber, S.,Hug, M.N.,Koldewey, P.,D'Osualdo, A.,Schlatter, D.,Stoll, T.,Rudolph, M.G.
Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain.
J.Biol.Chem., 295:7849-7864, 2020
Cited by
PubMed: 32317279
DOI: 10.1074/jbc.RA120.012788
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.27 Å)
Structure validation

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