5QU4

Crystal Structure of swapped human Nck SH3.1 domain, 1.05A, orthorhombic form I

Summary for 5QU4

Entry DOI	10.2210/pdb5qu4/pdb
Group deposition	structural plasticity of the Nck1-SH3.1 domain (G_1002110)
Descriptor	Cytoplasmic protein NCK1 (2 entities in total)
Functional Keywords	sh3 domain, adaptor, peptide binding, signaling protein, domain swap
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	41197.64
Authors	Rudolph, M.G. (deposition date: 2019-12-13, release date: 2020-02-12, Last modification date: 2024-04-03)
Primary citation	Richter, K.,Rufer, A.C.,Muller, M.,Burger, D.,Casagrande, F.,Grossenbacher, T.,Huber, S.,Hug, M.N.,Koldewey, P.,D'Osualdo, A.,Schlatter, D.,Stoll, T.,Rudolph, M.G. Small molecule AX-024 reduces T cell proliferation independently of CD3ε/Nck1 interaction, which is governed by a domain swap in the Nck1-SH3.1 domain. J.Biol.Chem., 295:7849-7864, 2020 Cited by PubMed: 32317279 DOI: 10.1074/jbc.RA120.012788 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.05 Å)

Structure validation