1AZG
NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE KINASE COMPLEXED WITH THE SYNTHETIC PEPTIDE P2L CORRESPONDING TO RESIDUES 91-104 OF THE P85 SUBUNIT OF PI3-KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE
Summary for 1AZG
Entry DOI | 10.2210/pdb1azg/pdb |
Descriptor | PRO-PRO-ARG-PRO-LEU-PRO-VAL-ALA-PRO-GLY-SER-SER-LYS-THR, FYN (2 entities in total) |
Functional Keywords | complex (phosphotransferase-peptide), sh3 domain, polyproline-binding, phosphotransferase, complex (phosphotransferase-peptide) complex, complex (phosphotransferase/peptide) |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: P06241 |
Total number of polymer chains | 2 |
Total formula weight | 8959.75 |
Authors | Renzoni, D.A.,Pugh, D.J.R.,Siligardi, G.,Das, P.,Morton, C.J.,Rossi, C.,Waterfield, M.D.,Campbell, I.D.,Ladbury, J.E. (deposition date: 1997-11-18, release date: 1998-02-25, Last modification date: 2024-05-22) |
Primary citation | Renzoni, D.A.,Pugh, D.J.,Siligardi, G.,Das, P.,Morton, C.J.,Rossi, C.,Waterfield, M.D.,Campbell, I.D.,Ladbury, J.E. Structural and thermodynamic characterization of the interaction of the SH3 domain from Fyn with the proline-rich binding site on the p85 subunit of PI3-kinase. Biochemistry, 35:15646-15653, 1996 Cited by PubMed: 8961927DOI: 10.1021/bi9620969 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)