PDB: 221716 resultsInfo pagesStatus searchChemie searchBIRD

---

8VM2	Crystal Structure of NRAS Q61K bound to GTP Descriptor: GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M. Deposit date: 2024-01-12 Release date: 2024-05-01 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II. Eur J Cell Biol, 103, 2024
8VLY	Cryo-EM structure of human HGSNAT in transition state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heparan-alpha-glucosaminide N-acetyltransferase Authors: Li, F, Zhao, B. Deposit date: 2024-01-12 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.61 Å) Cite: Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome To Be Published
8VLX	HTT in complex with HAP40 and a small molecule. Descriptor: 40-kDa huntingtin-associated protein, Huntingtin, N-[(1S,2R)-2-benzylcyclopentyl]-N'-{1-[(1S)-1-(pyridin-4-yl)ethyl]piperidin-4-yl}urea Authors: Poweleit, N, Boudet, J, Doherty, E. Deposit date: 2024-01-12 Release date: 2024-03-06 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Discovery of a Small Molecule Ligand to the Huntingtin/HAP40 complex To Be Published
8VLV	Cryo-EM structure of human HGSNAT in inactive state Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heparan-alpha-glucosaminide N-acetyltransferase Authors: Li, F. Deposit date: 2024-01-12 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.49 Å) Cite: Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome To Be Published
8VLU	Cryo-EM structure of human HGSNAT bound with CoA Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COENZYME A, Heparan-alpha-glucosaminide N-acetyltransferase Authors: Li, F, Zhao, B. Deposit date: 2024-01-12 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.12 Å) Cite: Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome To Be Published
8VLS	Structure of VCP in complex with an ATPase activator (D2 domains only, dodecameric form) Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase Authors: Jones, N.H, Urnivicius, L, Kapoor, T.M. Deposit date: 2024-01-12 Release date: 2024-06-19 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
8VLQ	Structure of PmHMGR bound to mevalonate, CoA and NAD 5 minutes after reaction initiation at pH 9 Descriptor: (R)-MEVALONATE, (R)-mevaldehyde, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... Authors: Purohit, V, Steussy, C.N, Stauffacher, C.V. Deposit date: 2024-01-12 Release date: 2024-03-20 Method: X-RAY DIFFRACTION (2.07 Å) Cite: pH-dependent reaction triggering in PmHMGR crystals for time-resolved crystallography. Biophys.J., 123, 2024
8VLI	Cryo-EM structure of human HGSNAT bound with CoA and product analog Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-methyl-2-oxo-2H-1-benzopyran-7-yl 2-acetamido-2-deoxy-beta-D-glucopyranoside, ... Authors: Li, F, Zhao, B. Deposit date: 2024-01-11 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome To Be Published
8VLG	Cryo-EM structure of human HGSNAT bound with Acetyl-CoA and substrate analog Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-methyl-2-oxo-2H-1-benzopyran-7-yl 2-amino-2-deoxy-beta-D-glucopyranoside, ... Authors: Li, F, Zhao, B. Deposit date: 2024-01-11 Release date: 2024-06-26 Method: ELECTRON MICROSCOPY (3.15 Å) Cite: Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome To Be Published
8VLB	Crystal structure of EloBC-VHL-CDO1 complex bound to compound 4 molecular glue Descriptor: CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... Authors: Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. Deposit date: 2024-01-11 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
8VL9	Crystal structure of EloBC-VHL-CDO1 complex bound to compound 8 molecular glue Descriptor: CITRIC ACID, Cysteine dioxygenase type 1, Elongin-B, ... Authors: Shu, W, Ma, X, Tutter, A, Buckley, D, Golosov, A, Michaud, G. Deposit date: 2024-01-11 Release date: 2024-03-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A small molecule VHL molecular glue degrader for cysteine dioxygenase 1 To Be Published
8VL8	Salmonella enterica Typhimurium taxis to serine and repellents (Tsr) ligand-binding domain with L-Ser, pH 7 Descriptor: CHLORIDE ION, Methyl-accepting chemotaxis protein, POTASSIUM ION, ... Authors: Glenn, S, Baylink, A. Deposit date: 2024-01-11 Release date: 2024-04-03 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Human Serum is a Potent Chemoattractant for Enterobacteriaceae Species Associated with Gastrointestinal Bleeding eLife, 2024
8VL7	Co-crystal structure of human TREX1 in complex with an inhibitor Descriptor: (2P)-2-[3-bromo-2-(2-hydroxyethoxy)phenyl]-5-hydroxy-1-methyl-N-(1,2-oxazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... Authors: Dehghani-Tafti, S, Dong, A, Li, Y, Ackloo, S, Arrowsmith, C.H, Edwards, A.M, Halabelian, L. Deposit date: 2024-01-11 Release date: 2024-01-24 Method: X-RAY DIFFRACTION (1.88 Å) Cite: Co-crystal structure of human TREX1 in complex with an inhibitor To be published
8VL0	The crystal structure of wild-type CYP199A4 bound to 4-(2-oxopropyl)benzoic acid Descriptor: 4-(2-oxopropyl)benzoic acid, CHLORIDE ION, Cytochrome P450, ... Authors: Podgorski, M.N, Bell, S.G. Deposit date: 2024-01-11 Release date: 2024-05-08 Method: X-RAY DIFFRACTION (1.837 Å) Cite: The crystal structure of wild-type CYP199A4 bound to 4-(2-oxopropyl)benzoic acid To Be Published
8VKZ	Crystal structure of Glucocorticoid Receptor in complex with an inhibitor Descriptor: (4aR,4bS,5R,6aS,6bS,8R,9aR,10aR,10bR)-8-{4-[(3-aminophenyl)methyl]phenyl}-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, Glucocorticoid receptor, Nuclear receptor coactivator 2 Authors: Judge, R.A, Hobson, A.D. Deposit date: 2024-01-10 Release date: 2024-01-24 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.133 Å) Cite: Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties. Rsc Med Chem, 15, 2024
8VKU	Structure of VCP in complex with an ATPase activator (D2 domains only, hexameric form) Descriptor: (3R)-N-[2-(ethylsulfanyl)phenyl]-3-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)butanamide, Transitional endoplasmic reticulum ATPase Authors: Jones, N.H, Urnivicius, L, Kapoor, T.M. Deposit date: 2024-01-09 Release date: 2024-06-19 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Allosteric activation of VCP, an AAA unfoldase, by small molecule mimicry. Proc.Natl.Acad.Sci.USA, 121, 2024
8VKT	Crystallographic structure of dimetalated DapE from Enterococcus faecium Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Probable succinyl-diaminopimelate desuccinylase, ... Authors: Gonzalez-Segura, L, Diaz-Vilchis, A, Terrazas-Lopez, M, Diaz-Sanchez, A.G. Deposit date: 2024-01-09 Release date: 2024-05-29 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (1.398 Å) Cite: The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity. Int.J.Biol.Macromol., 270, 2024
8VKR	CW Flagellar Switch Complex with extra density - FliF, FliG, FliM, and FliN forming the C-ring from Salmonella Descriptor: Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... Authors: Singh, P.K, Iverson, T.M. Deposit date: 2024-01-09 Release date: 2024-02-28 Method: ELECTRON MICROSCOPY (5.9 Å) Cite: Structural basis for rotation and directional switching by the combined MS- and C-rings of bacterial flagella. To Be Published
8VKQ	CW Flagellar Switch Complex - FliF, FliG, FliM, and FliN forming the C-ring from Salmonella Descriptor: Flagellar M-ring protein, Flagellar motor switch protein FliG, Flagellar motor switch protein FliM, ... Authors: Singh, P.K, Iverson, T.M. Deposit date: 2024-01-09 Release date: 2024-02-28 Last modified: 2024-04-24 Method: ELECTRON MICROSCOPY (4.6 Å) Cite: Structural basis for rotation and directional switching by the combined MS- and C-rings of bacterial flagella. To Be Published
8VKP	Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with human ACE2 (focused refinement of RBD and ACE2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... Authors: Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. Deposit date: 2024-01-09 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition To Be Published
8VKO	Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with human ACE2 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... Authors: Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. Deposit date: 2024-01-09 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (2.68 Å) Cite: SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition To Be Published
8VKN	Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (focused refinement of RBD and mouse ACE2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. Deposit date: 2024-01-09 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (2.93 Å) Cite: SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition To Be Published
8VKM	Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 1) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. Deposit date: 2024-01-09 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (2.83 Å) Cite: SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition To Be Published
8VKL	Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein in complex with mouse ACE2 (conformation 2) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... Authors: Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. Deposit date: 2024-01-09 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (2.91 Å) Cite: SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition To Be Published
8VKK	Cryo-EM structure of SARS-CoV-2 XBB.1.5 spike protein Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein Authors: Zhu, X, Mannar, D, Saville, J, Poloni, C, Bezeruk, A, Tidey, K, Ahmed, S, Tuttle, K, Vahdatihassani, F, Cholak, S, Cook, L, Steiner, T.S, Subramaniam, S. Deposit date: 2024-01-09 Release date: 2024-02-14 Method: ELECTRON MICROSCOPY (2.81 Å) Cite: SARS-CoV-2 XBB.1.5 Spike Protein: Altered Receptor Binding, Antibody Evasion, and Retention of T Cell Recognition To Be Published

<60616263646566676869707172737475>