8VKZ

Crystal structure of Glucocorticoid Receptor in complex with an inhibitor

This is a non-PDB format compatible entry.

Summary for 8VKZ

• Entry DOI: 10.2210/pdb8vkz/pdb
• Descriptor: Glucocorticoid receptor, Nuclear receptor coactivator 2, (4aR,4bS,5R,6aS,6bS,8R,9aR,10aR,10bR)-8-{4-[(3-aminophenyl)methyl]phenyl}-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one, ... (4 entities in total)
• Functional Keywords: glucocorticord receptor, modulator, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 63143.28

Authors

Judge, R.A.,Hobson, A.D. (deposition date: 2024-01-10, release date: 2024-01-24, Last modification date: 2024-05-08)

• Primary citation: Hobson, A.D.,Zhu, H.,Qiu, W.,Judge, R.A.,Longenecker, K.; Minimising the payload solvent exposed hydrophobic surface area optimises the antibody-drug conjugate properties.; Rsc Med Chem, 15:832-838, 2024; PubMed: 38516584; DOI: 10.1039/d3md00540b

Experimental method

X-RAY DIFFRACTION (2.133 Å)