8VKZ
Crystal structure of Glucocorticoid Receptor in complex with an inhibitor
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glucocorticoid receptor | polymer | 252 | 29293.0 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 2 | C, D (D, E) | Nuclear receptor coactivator 2 | polymer | 14 | 1708.9 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | E, F (A, B) | (4aR,4bS,5R,6aS,6bS,8R,9aR,10aR,10bR)-8-{4-[(3-aminophenyl)methyl]phenyl}-5-hydroxy-6b-(hydroxyacetyl)-4a,6a-dimethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one | non-polymer | 569.7 | 2 | Chemie (A1ACE) | |||
| 4 | G, H, I, J (A, B, D, E) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B: 528 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 526 | - | expression tag |
| Ser 527 | - | expression tag |
| Met 571 | Val 571 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62003.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1139.4 | |
| All* | Total formula weight | 63143.3 |
