8VL7

Co-crystal structure of human TREX1 in complex with an inhibitor

This is a non-PDB format compatible entry.

Summary for 8VL7

• Entry DOI: 10.2210/pdb8vl7/pdb
• Descriptor: Three-prime repair exonuclease 1, (2P)-2-[3-bromo-2-(2-hydroxyethoxy)phenyl]-5-hydroxy-1-methyl-N-(1,2-oxazol-4-yl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, GLYCEROL, ... (8 entities in total)
• Functional Keywords: trex1, inhibitor, nuclease, sgc, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 204847.50

Authors

Dehghani-Tafti, S.,Dong, A.,Li, Y.,Ackloo, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L. (deposition date: 2024-01-11, release date: 2024-01-24)

• Primary citation: Dehghani-Tafti, S.,Dong, A.,Li, Y.,Ackloo, S.,Arrowsmith, C.H.,Edwards, A.M.,Halabelian, L.; Co-crystal structure of human TREX1 in complex with an inhibitor; To be published,

Experimental method

X-RAY DIFFRACTION (1.88 Å)