2AZN
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![BU of 2azn by Molmil](/molmil-images/mine/2azn) | X-RAY Structure of 2,5-diamino-6-ribosylamino-4(3h)-pyrimidinone 5-phosphate reductase | Descriptor: | 2-(6-(2-CYCLOHEXYLETHOXY)-TETRAHYDRO-4,5-DIHYDROXY-2(HYDROXYMETHYL)-2H-PYRAN-3-YLOXY)-TETRAHYDRO-6(HYDROXYMETHYL)-2H-PYRAN-3,4,5-TRIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Chatwell, L, Bacher, A, Huber, R, Fischer, M, Krojer, T. | Deposit date: | 2005-09-12 | Release date: | 2006-08-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Biosynthesis of riboflavin: structure and properties of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase of Methanocaldococcus jannaschii J.Mol.Biol., 359, 2006
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6WWB
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![BU of 6wwb by Molmil](/molmil-images/mine/6wwb) | Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b | Descriptor: | 1,2-ETHANEDIOL, 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide, Bromodomain-containing protein 2 | Authors: | White, S.W, Yun, M. | Deposit date: | 2020-05-08 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew.Chem.Int.Ed.Engl., 60, 2021
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2B3V
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![BU of 2b3v by Molmil](/molmil-images/mine/2b3v) | Spermine spermidine acetyltransferase in complex with acetylcoa, K26R mutant | Descriptor: | ACETYL COENZYME *A, Diamine acetyltransferase 1 | Authors: | Bewley, M.C, Graziano, V, Jiang, J.S, Matz, E, Studier, F.W, Pegg, A.P, Coleman, C.S, Flanagan, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2005-09-21 | Release date: | 2006-01-17 | Last modified: | 2021-02-03 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target. Proc.Natl.Acad.Sci.USA, 103, 2006
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2B0V
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![BU of 2b0v by Molmil](/molmil-images/mine/2b0v) | NUDIX hydrolase from Nitrosomonas europaea. | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, NUDIX hydrolase, ... | Authors: | Osipiuk, J, Skarina, T, Savchenko, A, Edwards, A, Joachimiak, A, MCSG, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-09-14 | Release date: | 2005-09-27 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | X-ray structure of NUDIX hydrolase from Nitrosomonas europaea. To be Published
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2BAL
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![BU of 2bal by Molmil](/molmil-images/mine/2bal) | p38alpha MAP kinase bound to pyrazoloamine | Descriptor: | Mitogen-activated protein kinase 14, [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE | Authors: | Gerhardt, S, Pauptit, R.A, Read, J, Tucker, J, Norman, R.A, Breed, J. | Deposit date: | 2005-10-14 | Release date: | 2005-12-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Prevention of MKK6-Dependent Activation by Binding to p38alpha MAP Kinase. Biochemistry, 44, 2005
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2B5F
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![BU of 2b5f by Molmil](/molmil-images/mine/2b5f) | Crystal structure of the spinach aquaporin SoPIP2;1 in an open conformation to 3.9 resolution | Descriptor: | aquaporin | Authors: | Tornroth-Horsefield, S, Wang, Y, Hedfalk, K, Johanson, U, Karlsson, M, Tajkhorshid, E, Neutze, R, Kjellbom, P. | Deposit date: | 2005-09-28 | Release date: | 2005-12-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.9 Å) | Cite: | Structural mechanism of plant aquaporin gating Nature, 439, 2006
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2B67
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![BU of 2b67 by Molmil](/molmil-images/mine/2b67) | Crystal structure of the Nitroreductase Family Protein from Streptococcus pneumoniae TIGR4 | Descriptor: | ACETIC ACID, COG0778: Nitroreductase, FLAVIN MONONUCLEOTIDE | Authors: | Kim, Y, Volkart, L, Abdullah, J, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-09-30 | Release date: | 2005-11-15 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal Structure of the Nitroreductase Family Protein from Streptococcus pneumoniae TIGR4 To be Published
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2B7P
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![BU of 2b7p by Molmil](/molmil-images/mine/2b7p) | Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori with phthalic acid | Descriptor: | PHTHALIC ACID, Probable nicotinate-nucleotide pyrophosphorylase, SULFATE ION | Authors: | Kim, M.K, Im, Y.J, Lee, J.H, Eom, S.H. | Deposit date: | 2005-10-05 | Release date: | 2006-02-14 | Last modified: | 2018-09-19 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Crystal structure of quinolinic acid phosphoribosyltransferase from Helicobacter pylori Proteins, 63, 2006
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2B6C
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![BU of 2b6c by Molmil](/molmil-images/mine/2b6c) | Predicted DNA alkylation repair enzyme from Enterococcus faecalis. | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, GLYCEROL, ... | Authors: | Osipiuk, J, Hatzos, C, Moy, S, Collart, F, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-09-30 | Release date: | 2005-11-15 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Xray structure of predicted DNA alkylation repair enzyme from Enterococcus faecalis. To be Published
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6OFY
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![BU of 6ofy by Molmil](/molmil-images/mine/6ofy) | Crystal Structure of Arachidonic Acid bound to V349I murine COX-2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACRYLIC ACID, ARACHIDONIC ACID, ... | Authors: | Malkowski, M.G. | Deposit date: | 2019-04-01 | Release date: | 2020-02-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex. Biochemistry, 58, 2019
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4UYK
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![BU of 4uyk by Molmil](/molmil-images/mine/4uyk) | Crystal structure of a Signal Recognition Particle Alu domain in the elongation arrest conformation | Descriptor: | SIGNAL RECOGNITION PARTICLE 14 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, SRP RNA | Authors: | Bousset, L, Mary, C, Brooks, M.A, Scherrer, A, Strub, K, Cusack, S. | Deposit date: | 2014-09-01 | Release date: | 2014-11-05 | Last modified: | 2014-12-03 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Crystal Structure of a Signal Recognition Particle Alu Domain in the Elongation Arrest Conformation. RNA, 20, 2014
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4UV2
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![BU of 4uv2 by Molmil](/molmil-images/mine/4uv2) | Structure of the curli transport lipoprotein CsgG in a non-lipidated, pre-pore conformation | Descriptor: | CURLI PRODUCTION TRANSPORT COMPONENT CSGG | Authors: | Goyal, P, Krasteva, P.V, Gerven, N.V, Gubellini, F, Broeck, I.V.D, Troupiotis-Tsailaki, A, Jonckheere, W, Pehau-Arnaudet, G, Pinkner, J.S, Chapman, M.R, Hultgren, S.J, Howorka, S, Fronzes, R, Remaut, H. | Deposit date: | 2014-08-04 | Release date: | 2014-09-24 | Last modified: | 2014-12-17 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural and Mechanistic Insights Into the Bacterial Amyloid Secretion Channel Csgg. Nature, 516, 2014
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4V2D
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![BU of 4v2d by Molmil](/molmil-images/mine/4v2d) | FLRT2 LRR domain | Descriptor: | FIBRONECTIN LEUCINE RICH TRANSMEMBRANE PROTEIN 2 | Authors: | Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R. | Deposit date: | 2014-10-08 | Release date: | 2014-11-05 | Last modified: | 2015-07-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development Neuron, 84, 2014
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6DS5
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![BU of 6ds5 by Molmil](/molmil-images/mine/6ds5) | Cryo EM structure of human SEIPIN | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Seipin | Authors: | Yan, R.H, Qian, H.W, Yan, N, Yang, H.Y. | Deposit date: | 2018-06-13 | Release date: | 2018-10-24 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Human SEIPIN Binds Anionic Phospholipids. Dev. Cell, 47, 2018
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4UW9
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![BU of 4uw9 by Molmil](/molmil-images/mine/4uw9) | |
4V34
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![BU of 4v34 by Molmil](/molmil-images/mine/4v34) | The Structure of A-PGS from Pseudomonas aeruginosa (SeMet derivative) | Descriptor: | ALANYL-TRNA-DEPENDENT L-ALANYL- PHOPHATIDYLGLYCEROL SYNTHASE, CHLORIDE ION, SULFATE ION | Authors: | Krausze, J, Hebecker, S, Hasenkampf, T, Heinz, D.W, Moser, J. | Deposit date: | 2014-10-16 | Release date: | 2015-08-19 | Last modified: | 2017-07-12 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of Two Bacterial Resistance Factors Mediating tRNA-Dependent Aminoacylation of Phosphatidylglycerol with Lysine or Alanine. Proc.Natl.Acad.Sci.USA, 112, 2015
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4UYT
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![BU of 4uyt by Molmil](/molmil-images/mine/4uyt) | X-ray structure of the N-terminal domain of the flocculin Flo11 from Saccharomyces cerevisiae | Descriptor: | ACETATE ION, FLOCCULATION PROTEIN FLO11, SODIUM ION | Authors: | Kraushaar, T, Veelders, M, Brueckner, S, Rhinow, D, Moesch, H.U, Essen, L.O. | Deposit date: | 2014-09-03 | Release date: | 2015-08-12 | Method: | X-RAY DIFFRACTION (1.03 Å) | Cite: | Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-Like Adhesin Domain Girdled by Aromatic Bands. Structure, 23, 2015
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4V0N
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![BU of 4v0n by Molmil](/molmil-images/mine/4v0n) | |
4V2P
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![BU of 4v2p by Molmil](/molmil-images/mine/4v2p) | Ketosynthase MxnB | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, KETOSYNTHASE, ... | Authors: | Koehnke, J. | Deposit date: | 2014-10-13 | Release date: | 2015-08-26 | Last modified: | 2018-04-18 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | In vitro reconstitution of alpha-pyrone ring formation in myxopyronin biosynthesis. Chem Sci, 6, 2015
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4UYR
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![BU of 4uyr by Molmil](/molmil-images/mine/4uyr) | X-ray structure of the N-terminal domain of the flocculin Flo11 from Saccharomyces cerevisiae | Descriptor: | FLOCCULATION PROTEIN FLO11, MAGNESIUM ION, PHOSPHATE ION, ... | Authors: | Veelders, M, Kraushaar, T, Brueckner, S, Rhinow, D, Moesch, H.U, Essen, L.O. | Deposit date: | 2014-09-03 | Release date: | 2015-08-12 | Last modified: | 2017-06-28 | Method: | X-RAY DIFFRACTION (0.89 Å) | Cite: | Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-Like Adhesin Domain Girdled by Aromatic Bands. Structure, 23, 2015
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4UYS
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![BU of 4uys by Molmil](/molmil-images/mine/4uys) | X-ray structure of the N-terminal domain of the flocculin Flo11 from Saccharomyces cerevisiae | Descriptor: | FLOCCULATION PROTEIN FLO11, MAGNESIUM ION, SODIUM ION | Authors: | Kraushaar, T, Veelders, M, Brueckner, S, Rhinow, D, Moesch, H.U, Essen, L.O. | Deposit date: | 2014-09-03 | Release date: | 2015-08-12 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Interactions by the Fungal Flo11 Adhesin Depend on a Fibronectin Type III-Like Adhesin Domain Girdled by Aromatic Bands. Structure, 23, 2015
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6DMB
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![BU of 6dmb by Molmil](/molmil-images/mine/6dmb) | Cryo-EM structure of human Ptch1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Yan, N, Gong, X, Qian, H.W. | Deposit date: | 2018-06-04 | Release date: | 2018-07-11 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for the recognition of Sonic Hedgehog by human Patched1. Science, 361, 2018
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4WBG
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![BU of 4wbg by Molmil](/molmil-images/mine/4wbg) | Crystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenam | Descriptor: | 2-({[(1Z)-1-(2-amino-1,3-thiazol-4-yl)-2-oxo-2-{[(2S,3S)-1-oxo-3-(sulfoamino)butan-2-yl]amino}ethylidene]amino}oxy)-2-methylpropanoic acid, ACETATE ION, Beta-lactamase, ... | Authors: | Oguri, T, Shimizu-ibuka, A, Ishii, Y. | Deposit date: | 2014-09-03 | Release date: | 2015-07-01 | Last modified: | 2020-01-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational Change Observed in the Active Site of Class C beta-Lactamase MOX-1 upon Binding to Aztreonam Antimicrob.Agents Chemother., 59, 2015
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6DG8
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![BU of 6dg8 by Molmil](/molmil-images/mine/6dg8) | Full-length 5-HT3A receptor in a serotonin-bound conformation- State 2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-hydroxytryptamine receptor 3A, SEROTONIN, ... | Authors: | Basak, S, Chakrapani, S. | Deposit date: | 2018-05-17 | Release date: | 2018-11-07 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.89 Å) | Cite: | Cryo-EM reveals two distinct serotonin-bound conformations of full-length 5-HT3Areceptor. Nature, 563, 2018
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4WD3
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![BU of 4wd3 by Molmil](/molmil-images/mine/4wd3) | Crystal structure of an L-amino acid ligase RizA | Descriptor: | L-amino acid ligase | Authors: | Kagawa, W, Arai, T, Kino, K, Kurumizaka, H. | Deposit date: | 2014-09-06 | Release date: | 2015-09-09 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure of RizA, an L-amino-acid ligase from Bacillus subtilis. Acta Crystallogr.,Sect.F, 71, 2015
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