6WWB
Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b
Summary for 6WWB
Entry DOI | 10.2210/pdb6wwb/pdb |
Descriptor | Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide, ... (4 entities in total) |
Functional Keywords | bet, brd2, bromodomain, inhibitor, complex, transcription, protac |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 14576.04 |
Authors | White, S.W.,Yun, M. (deposition date: 2020-05-08, release date: 2021-11-17, Last modification date: 2023-10-18) |
Primary citation | Min, J.,Mayasundari, A.,Keramatnia, F.,Jonchere, B.,Yang, S.W.,Jarusiewicz, J.,Actis, M.,Das, S.,Young, B.,Slavish, J.,Yang, L.,Li, Y.,Fu, X.,Garrett, S.H.,Yun, M.K.,Li, Z.,Nithianantham, S.,Chai, S.,Chen, T.,Shelat, A.,Lee, R.E.,Nishiguchi, G.,White, S.W.,Roussel, M.F.,Potts, P.R.,Fischer, M.,Rankovic, Z. Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. Angew.Chem.Int.Ed.Engl., 60:26663-26670, 2021 Cited by PubMed: 34614283DOI: 10.1002/anie.202108848 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.31 Å) |
Structure validation
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