6WWB
Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 115 | 13524.5 | 1 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (Human) | O27.1.1,Really interesting new gene 3 protein |
| 2 | B, C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 3 | E (A) | 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide | non-polymer | 865.4 | 1 | Chemie (YA3) | |||
| 4 | F (A) | water | water | 18.0 | 116 | Chemie (HOH) |
Sequence modifications
A: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Gly 341 | - | expression tag |
| Ser 342 | - | expression tag |
| His 343 | - | expression tag |
| Met 344 | - | expression tag |
| Gln 345 | - | expression tag |
| Asp 346 | - | expression tag |
| Pro 347 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13524.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1051.6 | |
| All* | Total formula weight | 14576.0 |
