6WWB
Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 501 |
| Chain | Residue |
| A | TYR426 |
| A | ARG440 |
| A | GLN443 |
| A | GLN443 |
| A | ASP444 |
| A | PHE448 |
| A | HOH619 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 502 |
| Chain | Residue |
| A | ASP407 |
| A | MET438 |
| A | LYS441 |
| A | HOH602 |
| A | TYR368 |
| A | LYS402 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | LYS351 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue YA3 A 504 |
| Chain | Residue |
| A | PRO371 |
| A | LEU383 |
| A | ASN429 |
| A | HIS433 |
| A | VAL435 |
| A | HOH610 |
| A | HOH617 |
| A | HOH622 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 60 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFykpvDasalglhDYHdiIkhpMdlstVkrkmenrd..Yrdaqefaadvrl.MfsNCykY |
| Chain | Residue | Details |
| A | ALA369-TYR428 |
