1MF4
| Structure-based design of potent and selective inhibitors of phospholipase A2: Crystal structure of the complex formed between phosholipase A2 from Naja Naja sagittifera and a designed peptide inhibitor at 1.9 A resolution | Descriptor: | CALCIUM ION, Phospholipase A2, VAL-ALA-PHE-ARG-SER | Authors: | Singh, R.K, Vikram, P, Paramsivam, M, Jabeen, T, Sharma, S, Makker, J, Dey, S, Kaur, P, Srinivasan, A, Singh, T.P. | Deposit date: | 2002-08-09 | Release date: | 2003-09-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Design of specific peptide inhibitors for group I phospholipase A2: structure of a complex formed between phospholipase A2 from Naja naja sagittifera (group I) and a designed peptide inhibitor Val-Ala-Phe-Arg-Ser (VAFRS) at 1.9 A resolution reveals unique features Biochemistry, 42, 2003
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1MKS
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2ZP5
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2ZP4
| Carboxylic ester hydrolase, single mutant h48n of bovine pancreatic pla2 enzyme | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Kanaujia, S.P, Sekar, K. | Deposit date: | 2008-06-27 | Release date: | 2008-11-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures and molecular-dynamics studies of three active-site mutants of bovine pancreatic phospholipase A(2) Acta Crystallogr.,Sect.D, 64, 2008
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2ZP3
| Carboxylic ester hydrolase, single mutant d49n of bovine pancreatic pla2 enzyme | Descriptor: | (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ... | Authors: | Kanaujia, S.P, Sekar, K. | Deposit date: | 2008-06-27 | Release date: | 2008-11-04 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structures and molecular-dynamics studies of three active-site mutants of bovine pancreatic phospholipase A(2) Acta Crystallogr.,Sect.D, 64, 2008
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1KVX
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1C74
| Structure of the double mutant (K53,56M) of phospholipase A2 | Descriptor: | CALCIUM ION, PHOSPHOLIPASE A2 | Authors: | Sekar, K, Tsai, M.D, Jain, M.K, Ramakumar, S. | Deposit date: | 2000-01-22 | Release date: | 2000-07-22 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of the anionic interface preference and k*cat activation of pancreatic phospholipase A2. Biochemistry, 39, 2000
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5OW8
| Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors | Descriptor: | 1-[3-(trifluoromethyl)phenyl]indole-2-carboxamide, CALCIUM ION, CHLORIDE ION, ... | Authors: | Sandmark, J.S, Roth, R.G, Knerr, L, Bodin, C, Pettersen, D. | Deposit date: | 2017-08-31 | Release date: | 2018-08-01 | Last modified: | 2021-05-05 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2Type X (sPLA2-X) Inhibitors. Acs Med.Chem.Lett., 9, 2018
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1GH4
| Structure of the triple mutant (K56M, K120M, K121M) of phospholipase A2 | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CALCIUM ION, PHOSPHOLIPASE A2 | Authors: | Sekar, K, Velmurugan, D, Tsai, M.D. | Deposit date: | 2000-11-09 | Release date: | 2001-05-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2. J.Mol.Biol., 324, 2002
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1Q5T
| Gln48 PLA2 separated from Vipoxin from the venom of Vipera ammodytes meridionalis. | Descriptor: | Phospholipase A2 inhibitor, SULFATE ION | Authors: | Georgieva, D.N, Perbandt, M, Rypniewski, W, Hristov, K, Genov, N, Betzel, C. | Deposit date: | 2003-08-11 | Release date: | 2004-05-04 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The X-ray structure of a snake venom Gln48 phospholipase A2 at 1.9A resolution reveals
anion-binding sites. Biochem.Biophys.Res.Commun., 316, 2004
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5WZO
| Crystal structure of human secreted phospholipase A2 group IIE, crystallized with calcium | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Hou, S, Xu, J, Xu, T, Liu, J. | Deposit date: | 2017-01-18 | Release date: | 2018-01-24 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A2 group IIE Sci Rep, 7, 2017
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2AZY
| Crystal Structure of Porcine Pancreatic Phospholipase A2 in Complex with Cholate | Descriptor: | CALCIUM ION, CHOLIC ACID, Phospholipase A2, ... | Authors: | Pan, Y.H, Bahnson, B.J, Jain, M.K. | Deposit date: | 2005-09-12 | Release date: | 2006-11-14 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for bile salt inhibition of pancreatic phospholipase A2. J.Mol.Biol., 369, 2007
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1KVY
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3HZD
| Crystal structure of bothropstoxin-I (BthTX-I), a PLA2 homologue from Bothrops jararacussu venom | Descriptor: | LITHIUM ION, Phospholipase A2 homolog bothropstoxin-1 | Authors: | Silva, M.C.O, Marchi-Salvador, D.P, Fernandes, C.A.H, Soares, A.M, Fontes, M.R.M. | Deposit date: | 2009-06-23 | Release date: | 2009-07-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s. J.Struct.Biol., 171, 2010
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1FDK
| CARBOXYLIC ESTER HYDROLASE (PLA2-MJ33 INHIBITOR COMPLEX) | Descriptor: | 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL, CALCIUM ION, PHOSPHOLIPASE A2 | Authors: | Sundaralingam, M. | Deposit date: | 1997-09-04 | Release date: | 1998-10-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,. Biochemistry, 36, 1997
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4KF3
| Crystal Structure of Myotoxin II (MjTX-II), a myotoxic Lys49-phospholipase A2 from Bothrops moojeni. | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog 2, ISOPROPYL ALCOHOL | Authors: | Salvador, G.H.M, dos Santos, J.I, Fontes, M.R.M. | Deposit date: | 2013-04-26 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Structural and functional studies with mytoxin II from Bothrops moojeni reveal remarkable similarities and differences compared to other catalytically inactive phospholipases A2-like. Toxicon, 72C, 2013
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2QVD
| Identification of a potent anti-inflammatory agent from the natural extract of plant Cardiospermun helicacabum: Crystal structure of the complex of phospholipase A2 with Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy at 1.93 A resolution | Descriptor: | BERBERINE, Phospholipase A2 VRV-PL-VIIIa | Authors: | Kumar, S, Chandra, D.N, Singh, N, Jithesh, O, Sharma, S, Haridas, M, Singh, T.P. | Deposit date: | 2007-08-08 | Release date: | 2007-08-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93A and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine Biochim.Biophys.Acta, 1814, 2011
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1OXR
| Aspirin induces its Anti-inflammatory effects through its specific binding to Phospholipase A2: Crystal structure of the complex formed between Phospholipase A2 and Aspirin at 1.9A resolution | Descriptor: | 2-(ACETYLOXY)BENZOIC ACID, CALCIUM ION, Phospholipase A2 isoform 3 | Authors: | Singh, R.K, Ethayathulla, A.S, Jabeen, T, Sharma, S, Kaur, P, Srinivasan, A, Singh, T.P. | Deposit date: | 2003-04-03 | Release date: | 2004-04-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Aspirin induces its anti-inflammatory effects through its specific binding to phospholipase A2: crystal structure of the complex formed between phospholipase A2 and aspirin at 1.9 angstroms resolution. J.Drug Target., 13, 2005
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6DIK
| Crystal structure of Bothropstoxin I (BthTX-I) complexed to Chicoric acid | Descriptor: | (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid, BICARBONATE ION, Basic phospholipase A2 homolog bothropstoxin-1, ... | Authors: | Cardoso, F.F, Salvador, G.H.M, Borges, R.J. | Deposit date: | 2018-05-23 | Release date: | 2018-10-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins. Biochim Biophys Acta Gen Subj, 1862, 2018
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6B80
| Crystal structure of myotoxin II from Bothrops moojeni complexed to myristic acid | Descriptor: | 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Basic phospholipase A2 homolog 2, MYRISTIC ACID, ... | Authors: | Salvador, G.H.M, dos Santos, J.I, Fontes, M.R.M. | Deposit date: | 2017-10-05 | Release date: | 2018-10-03 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Structural evidence for a fatty acid-independent myotoxic mechanism for a phospholipase A2-like toxin. Biochim Biophys Acta Proteins Proteom, 1866, 2018
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2QHD
| Crystal structure of ecarpholin S (ser49-PLA2) complexed with fatty acid | Descriptor: | LAURIC ACID, Phospholipase A2 | Authors: | Zhou, X, Tan, T.C, Valiyaveettil, S, Go, M.L, Kini, R.M, Sivaraman, J. | Deposit date: | 2007-07-02 | Release date: | 2007-10-16 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural Characterization of Myotoxic Ecarpholin S from Echis carinatus Venom Biophys.J., 95, 2008
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1ZYX
| Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic anti-inflammatory agent licofelone at 1.9A resolution | Descriptor: | Phospholipase A2 VRV-PL-VIIIa, SULFATE ION, [6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YL]ACETIC ACID | Authors: | Singh, N, Jabeen, T, Sharma, S, Bhushan, A, Singh, T.P. | Deposit date: | 2005-06-13 | Release date: | 2005-06-28 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of the complex of a group IIA phospholipase A2 with a synthetic anti-inflammatory agent licofelone at 1.9A resolution To be Published
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7M6C
| Crystal structure of PLA2 from snake venom of peruvian Bothrops atrox | Descriptor: | Basic phospholipase A2, LAURIC ACID | Authors: | Leonardo, D.A, Chojnowski, G, Simpkin, A, Seifert-Davila, W, Vivas-Ruiz, D.E, Keegan, R, Rigden, D. | Deposit date: | 2021-03-25 | Release date: | 2022-01-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | findMySequence: a neural-network-based approach for identification of unknown proteins in X-ray crystallography and cryo-EM Iucrj, 9, 2022
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1KVW
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1FB2
| STRUCTURE OF PHOSPHOLIPASE A2 FROM DABOIA RUSSELLI PULCHELLA AT 1.95 | Descriptor: | PHOSPHOLIPASE A2 | Authors: | Chandra, V, Kaur, P, Betzel, C, Singh, T.P. | Deposit date: | 2000-07-14 | Release date: | 2001-07-25 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Regulation of catalytic function by molecular association: structure of phospholipase A2 from Daboia russelli pulchella (DPLA2) at 1.9 A resolution. Acta Crystallogr.,Sect.D, 57, 2001
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