6DIK

Crystal structure of Bothropstoxin I (BthTX-I) complexed to Chicoric acid

Summary for 6DIK

• Entry DOI: 10.2210/pdb6dik/pdb
• Related: 3IQ3
• Descriptor: Basic phospholipase A2 homolog bothropstoxin-1, (2R,3R)-2,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}butanedioic acid, SULFATE ION, ... (6 entities in total)
• Functional Keywords: bothropd jararacussu, bthtx-i, inhibitor, chicoric acid, cichoric acid, pla2, toxin
• Biological source: Bothrops jararacussu (Jararacussu)
• Total number of polymer chains: 2
• Total formula weight: 28566.07

Authors

Cardoso, F.F.,Salvador, G.H.M.,Borges, R.J. (deposition date: 2018-05-23, release date: 2018-10-03, Last modification date: 2023-10-11)

• Primary citation: Cardoso, F.F.,Borges, R.J.,Dreyer, T.R.,Salvador, G.H.M.,Cavalcante, W.L.G.,Pai, M.D.,Gallacci, M.,Fontes, M.R.M.; Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins.; Biochim Biophys Acta Gen Subj, 1862:2728-2737, 2018; PubMed: 30251662; DOI: 10.1016/j.bbagen.2018.08.002

Experimental method

X-RAY DIFFRACTION (1.93 Å)