3IQ3

Crystal Structure of Bothropstoxin-I complexed with polietilene glicol 4000 - crystallized at 283 K

Summary for 3IQ3

• Entry DOI: 10.2210/pdb3iq3/pdb
• Related: 2OK9 2OQD 2QOG 3HZD 3I3H 3I3I
• Descriptor: Phospholipase A2 homolog bothropstoxin-1, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, SULFATE ION, ... (4 entities in total)
• Functional Keywords: homologue phospholipase a2, bothropstoxin-i, bthtx-i_10c, lys49-pla2 from bothrops jararacussu, snake venom, antibiotic, antimicrobial, disulfide bond, myotoxin, secreted, toxin
• Biological source: Bothrops jararacussu (Jararacussu)
• Cellular location: Secreted: Q90249
• Total number of polymer chains: 2
• Total formula weight: 28759.73

Authors

Salvador, G.H.M.,Marchi-Salvador, D.P.,Silva, M.C.O.,Soares, A.M.,Fontes, M.R.M. (deposition date: 2009-08-19, release date: 2009-10-27, Last modification date: 2023-09-06)

• Primary citation: Fernandes, C.A.,Marchi-Salvador, D.P.,Salvador, G.M.,Silva, M.C.,Costa, T.R.,Soares, A.M.,Fontes, M.R.; Comparison between apo and complexed structures of bothropstoxin-I reveals the role of Lys122 and Ca(2+)-binding loop region for the catalytically inactive Lys49-PLA(2)s.; J.Struct.Biol., 171:31-43, 2010; PubMed: 20371382; DOI: 10.1016/j.jsb.2010.03.019

Experimental method

X-RAY DIFFRACTION (1.55 Å)