2QVD
Identification of a potent anti-inflammatory agent from the natural extract of plant Cardiospermun helicacabum: Crystal structure of the complex of phospholipase A2 with Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy at 1.93 A resolution
Summary for 2QVD
Entry DOI | 10.2210/pdb2qvd/pdb |
Related | 2OYF 2PYC |
Descriptor | Phospholipase A2 VRV-PL-VIIIa, BERBERINE (3 entities in total) |
Functional Keywords | phospholipids, membrane, hydrolysis, inhibitor, plant extraxt, lipid degradation, metal-binding, neurotoxin, presynaptic neurotoxin, secreted, toxin, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Daboia russellii pulchella (Russell's viper) |
Cellular location | Secreted: P59071 |
Total number of polymer chains | 1 |
Total formula weight | 13966.13 |
Authors | Kumar, S.,Chandra, D.N.,Singh, N.,Jithesh, O.,Sharma, S.,Haridas, M.,Singh, T.P. (deposition date: 2007-08-08, release date: 2007-08-21, Last modification date: 2023-10-25) |
Primary citation | Chandra, D.N.,Prasanth, G.K.,Singh, N.,Kumar, S.,Jithesh, O.,Sadasivan, C.,Sharma, S.,Singh, T.P.,Haridas, M. Identification of a novel and potent inhibitor of phospholipase A(2) in a medicinal plant: crystal structure at 1.93A and Surface Plasmon Resonance analysis of phospholipase A(2) complexed with berberine Biochim.Biophys.Acta, 1814:657-663, 2011 Cited by PubMed: 21420512DOI: 10.1016/j.bbapap.2011.03.002 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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