PDB: 92212 resultsInfo pagesStatus searchChemie searchBIRD

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7V7C	CryoEM structure of DDB1-VprBP-Vpr-UNG2(94-313) complex Descriptor: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1, Protein Vpr, ... Authors: Wang, D, Xu, J, Liu, Q, Xiang, Y. Deposit date: 2021-08-21 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
7V7B	CryoEM structure of DDB1-VprBP complex in ARM-up conformation Descriptor: DDB1- and CUL4-associated factor 1, DNA damage-binding protein 1 Authors: Wang, D, Xu, J, Liu, Q, Xiang, Y. Deposit date: 2021-08-21 Release date: 2022-08-31 Method: ELECTRON MICROSCOPY (4.2 Å) Cite: Structural insights into the HIV-1 Vpr mediated ubiquitination through the Cullin-RING E3 ubiquitin ligase To Be Published
2M85	PHD Domain from Human SHPRH Descriptor: E3 ubiquitin-protein ligase SHPRH, ZINC ION Authors: Machado, L.E.S.F, Pustovalova, Y, Pozhidaeva, A, Almeida, F.C.L, Bezsonova, I, Korzhnev, D.M. Deposit date: 2013-05-07 Release date: 2013-08-14 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: PHD domain from human SHPRH. J.Biomol.Nmr, 56, 2013
4P6W	Crystal Structure of mometasone furoate-bound glucocorticoid receptor ligand binding domain Descriptor: Glucocorticoid receptor, MOMETASONE FUROATE, Nuclear receptor coactivator 2 Authors: He, Y, Zhou, X.E, Tolbert, W.D, Powell, K, Melcher, K, Xu, H.E. Deposit date: 2014-03-25 Release date: 2014-04-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.951 Å) Cite: Structures and mechanism for the design of highly potent glucocorticoids. Cell Res., 24, 2014
4PP6	Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Resveratrol Descriptor: Estrogen receptor, Nuclear receptor coactivator 2, RESVERATROL Authors: Nwachukwu, J.C, Srinivasan, S, Bruno, N.E, Parent, A.A, Hughes, T.S, Pollock, J.A, Gjyshi, O, Cavett, V, Nowak, J, Garcia-Ordonez, R.D, Houtman, R, Griffin, P.R, Kojetin, D.J, Katzenellenbogen, J.A, Conkright, M.D, Nettles, K.W. Deposit date: 2014-02-26 Release date: 2014-05-07 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.201 Å) Cite: Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife, 3, 2014
7K03	Crystal structure of the tandem bromodomain (BD1 and BD2) of human TAF1 bound to ATR kinase inhibitor AZD6738 Descriptor: 1,2-ETHANEDIOL, 4-(4-{1-[(R)-amino(hydroxy)methyl-lambda~4~-sulfanyl]cyclopropyl}-6-[(3R)-3-methylmorpholin-4-yl]pyrimidin-2-yl)-1H-pyrrolo[2,3-b]pyridine, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-03 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
7K1P	Crystal structure of the second bromodomain (BD2) of human TAF1 bound to bromosporine Descriptor: 1,2-ETHANEDIOL, Bromosporine, Transcription initiation factor TFIID subunit 1 Authors: Karim, M.R, Schonbrunn, E. Deposit date: 2020-09-08 Release date: 2021-09-22 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.45 Å) Cite: Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain. J.Med.Chem., 65, 2022
5YBF	Crystal structure of the GluA2o LBD in complex with glutamate and HBT1 Descriptor: 2-[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]ethanoylamino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, ACETATE ION, GLUTAMIC ACID, ... Authors: Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. Deposit date: 2017-09-04 Release date: 2018-01-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J. Pharmacol. Exp. Ther., 364, 2018
7AYG	oxalyl-CoA decarboxylase from Methylorubrum extorquens with bound TPP and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative oxalyl-CoA decarboxylase (Oxc, ... Authors: Pfister, P, Burgener, S, Nattermann, M, Zarzycki, J, Erb, T.J. Deposit date: 2020-11-12 Release date: 2021-04-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism. Acs Catalysis, 11, 2021
7B2E	quadruple mutant of oxalyl-CoA decarboxylase from Methylorubrum extorquens with bound TPP and ADP Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative oxalyl-CoA decarboxylase (Oxc, ... Authors: Pfister, P, Burgener, S, Nattermann, M, Zarzycki, J, Erb, T.J. Deposit date: 2020-11-26 Release date: 2021-04-28 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Engineering a Highly Efficient Carboligase for Synthetic One-Carbon Metabolism. Acs Catalysis, 11, 2021
7AOS	crystal structure of the RARalpha/RXRalpha ligand binding domain heterodimer in complex with a fragment of SRC1 coactivator Descriptor: 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, GLYCEROL, ... Authors: le Maire, A, Guee, L, Bourguet, W. Deposit date: 2020-10-15 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.55 Å) Cite: Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433, 2021
7APO	Crystal structure of RARalpha ligand binding domain in complex with a fragment of the TIF2 coactivator Descriptor: 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid, GLYCEROL, Nuclear receptor coactivator 2, ... Authors: le Maire, A, Guee, L, Bourguet, W. Deposit date: 2020-10-19 Release date: 2021-08-04 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433, 2021
5YBG	Crystal structure of the GluA2o LBD in complex with glutamate and LY451395 Descriptor: ACETATE ION, GLUTAMIC ACID, GLYCEROL, ... Authors: Sogabe, S, Igaki, S, Hirokawa, A, Zama, Y, Lane, W, Snell, G. Deposit date: 2017-09-04 Release date: 2018-01-17 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.52 Å) Cite: HBT1, a Novel AMPA Receptor Potentiator with Lower Agonistic Effect, Avoided Bell-Shaped Response in In Vitro BDNF Production. J. Pharmacol. Exp. Ther., 364, 2018
4P6X	Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain Descriptor: (11alpha,14beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione, Glucocorticoid receptor, Nuclear receptor coactivator 2 Authors: He, Y, Zhou, X.E, Tolbert, W.D, Powell, K, Melcher, K, Xu, H.E. Deposit date: 2014-03-25 Release date: 2014-04-16 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures and mechanism for the design of highly potent glucocorticoids. Cell Res., 24, 2014
4XUM	PPARgamma ligand binding domain in complex with indomethacin Descriptor: INDOMETHACIN, Peroxisome proliferator-activated receptor gamma Authors: Puhl, A.C, Webb, P, Polikarpov, I. Deposit date: 2015-01-26 Release date: 2015-11-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs. Nucl Recept Signal, 13, 2015
4LZ5	Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators Descriptor: GLUTAMIC ACID, Glutamate receptor 2, N-[(2R)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide, ... Authors: Pandit, J. Deposit date: 2013-07-31 Release date: 2013-12-04 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators. J.Med.Chem., 56, 2013
5FP5	Structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (AT222) in an alternate binding site. Descriptor: 4-fluorobenzoic acid, ACETYL GROUP, CYCLIN-DEPENDENT KINASE 2 Authors: Jhoti, H, Ludlow, R.F, O'Reilly, M, Saini, H.K, Tickle, I.J, Verdonk, M. Deposit date: 2015-11-27 Release date: 2015-12-09 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.16 Å) Cite: Detection of Secondary Binding Sites in Proteins Using Fragment Screening. Proc.Natl.Acad.Sci.USA, 112, 2015
7SZU	Crystal structure of Pepper RNA aptamer in complex with HBC ligand and Fab BL3-6 Descriptor: 4-[(~{Z})-1-cyano-2-[4-[2-hydroxyethyl(methyl)amino]phenyl]ethenyl]benzenecarbonitrile, BL3-6 Fab heavy chain, BL3-6 Fab light chain, ... Authors: Rees, H.C, Piccirilli, J.A. Deposit date: 2021-11-29 Release date: 2022-07-06 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Structural Basis for Fluorescence Activation by Pepper RNA. Acs Chem.Biol., 17, 2022
1GUM	HUMAN GLUTATHIONE TRANSFERASE A4-4 WITHOUT LIGANDS Descriptor: PROTEIN (GLUTATHIONE TRANSFERASE A4-4) Authors: Bruns, C.M, Hubatsch, I, Ridderstrom, M, Mannervik, B, Tainer, J.A. Deposit date: 1998-06-11 Release date: 1999-01-27 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (3 Å) Cite: Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products J.Mol.Biol., 288, 1999
6FQI	GluA2(flop) G724C ligand binding core dimer bound to L-Glutamate (Form B) at 2.91 Angstrom resolution Descriptor: GLUTAMIC ACID, Glutamate receptor 2 Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2.91001153 Å) Cite: Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
6FQK	GluA2(flop) S729C ligand binding core dimer bound to ZK200775 at 1.98 Angstrom resolution Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2019-10-02 Method: X-RAY DIFFRACTION (1.98010445 Å) Cite: Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
6FQJ	GluA2(flop) G724C ligand binding core dimer bound to ZK200775 at 2.50 Angstrom resolution Descriptor: Glutamate receptor 2,Glutamate receptor 2, {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid Authors: Coombs, I.D, Soto, D, Gold, M.G, Farrant, M.F, Cull-Candy, S.G. Deposit date: 2018-02-14 Release date: 2019-03-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.500017 Å) Cite: Homomeric GluA2(R) AMPA receptors can conduct when desensitized. Nat Commun, 10, 2019
6V88	Solution NMR structure of Dictyostelium discoideum Skp1A (truncated) dimer Descriptor: SCF ubiquitin ligase complex protein SKP1a Authors: Kim, H.W, Eletsky, A, West, C.M. Deposit date: 2019-12-10 Release date: 2020-04-15 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Skp1 Dimerization Conceals Its F-Box Protein Binding Site. Biochemistry, 59, 2020
2GGX	Crystal structure of the trimer neck and carbohydrate recognition domain of human surfactant protein D in complex with p-nitrophenyl maltoside Descriptor: 4-NITROPHENYL 4-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GALACTOPYRANOSIDE, CALCIUM ION, Pulmonary surfactant-associated protein D Authors: Head, J. Deposit date: 2006-03-24 Release date: 2006-05-02 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Contributions of Phenylalanine 335 to Ligand Recognition by Human Surfactant Protein D: ring interactions with Sp-D ligands J.Biol.Chem., 281, 2006
5NGV	CRYSTAL STRUCTURE OF THE Activin receptor type-2B LIGAND BINDING DOMAIN IN COMPLEX WITH BIMAGRUMAB FV, ORTHORHOMBIC CRYSTAL FORM Descriptor: Activin receptor type-2B, TETRAETHYLENE GLYCOL, anti-human ActRIIB mAb BYM338 heavy-chain, ... Authors: Rondeau, J.-M, Lehmann, S. Deposit date: 2017-03-20 Release date: 2017-11-15 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2 Å) Cite: Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc. Natl. Acad. Sci. U.S.A., 114, 2017

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