7AOS

crystal structure of the RARalpha/RXRalpha ligand binding domain heterodimer in complex with a fragment of SRC1 coactivator

Summary for 7AOS

Entry DOI	10.2210/pdb7aos/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Retinoic acid receptor alpha, Nuclear receptor coactivator 1, ... (7 entities in total)
Functional Keywords	transcription factor, nuclear hormone receptor, coactivator, agonist, complex, hormone
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	4
Total formula weight	63565.48
Authors	le Maire, A.,Guee, L.,Bourguet, W. (deposition date: 2020-10-15, release date: 2021-08-04, Last modification date: 2024-01-31)
Primary citation	Senicourt, L.,le Maire, A.,Allemand, F.,Carvalho, J.E.,Guee, L.,Germain, P.,Schubert, M.,Bernado, P.,Bourguet, W.,Sibille, N. Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433:166899-166899, 2021 Cited by PubMed: 33647291 DOI: 10.1016/j.jmb.2021.166899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.55 Å)

Structure validation