7AOS
crystal structure of the RARalpha/RXRalpha ligand binding domain heterodimer in complex with a fragment of SRC1 coactivator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 238 | 26579.7 | 1 | UniProt (P28700) Pfam (PF00104) | Mus musculus (Mouse) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Retinoic acid receptor alpha | polymer | 266 | 29967.6 | 1 | UniProt (P10276) Pfam (PF00104) | Homo sapiens (Human) | RAR-alpha,Nuclear receptor subfamily 1 group B member 1 |
| 3 | C, D (C, D) | Nuclear receptor coactivator 1 | polymer | 27 | 3105.6 | 2 | UniProt (Q15788) | Homo sapiens | NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
| 4 | E (A) | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID | non-polymer | 363.5 | 1 | Chemie (LG2) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | G (B) | 4-{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}benzoic acid | non-polymer | 351.4 | 1 | Chemie (EQN) | |||
| 7 | H, I, J (A, B, C) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence modifications
B: 176 - 421 (UniProt: P10276)
| PDB | External Database | Details |
|---|---|---|
| Met 156 | - | initiating methionine |
| Gly 157 | - | expression tag |
| Ser 158 | - | expression tag |
| Ser 159 | - | expression tag |
| His 160 | - | expression tag |
| His 161 | - | expression tag |
| His 162 | - | expression tag |
| His 163 | - | expression tag |
| His 164 | - | expression tag |
| His 165 | - | expression tag |
| Ser 166 | - | expression tag |
| Ser 167 | - | expression tag |
| Gly 168 | - | expression tag |
| Leu 169 | - | expression tag |
| Val 170 | - | expression tag |
| Pro 171 | - | expression tag |
| Arg 172 | - | expression tag |
| Gly 173 | - | expression tag |
| Ser 174 | - | expression tag |
| His 175 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62758.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 807.0 | |
| All* | Total formula weight | 63565.5 |
