PPARgamma ligand binding domain in complex with indomethacin

Summary for 4XUM

Related4XTA 4XUH
DescriptorPeroxisome proliferator-activated receptor gamma, INDOMETHACIN (3 entities in total)
Functional Keywordsppargamma, nuclear receptor, transcription factor, nsaids, indomethacin, translation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus P37231
Total number of polymer chains2
Total molecular weight64543.09
Puhl, A.C.,Webb, P.,Polikarpov, I. (deposition date: 2015-01-26, release date: 2015-11-04)
Primary citation
Puhl, A.C.,Milton, F.A.,Cvoro, A.,Sieglaff, D.H.,Campos, J.C.,Bernardes, A.,Filgueira, C.S.,Lindemann, J.L.,Deng, T.,Neves, F.A.,Polikarpov, I.,Webb, P.
Mechanisms of peroxisome proliferator activated receptor gamma regulation by non-steroidal anti-inflammatory drugs.
Nucl Recept Signal, 13:e004-e004, 2015
PubMed: 26445566 (PDB entries with the same primary citation)
DOI: 10.1621/nrs.13004
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.239401.0%2.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report