6XA2
 
 | | Structure of the tirandamycin C-bound P450 monooxygenase TamI | | Descriptor: | (3E)-3-{(2E,4E,6R)-1-hydroxy-4-methyl-6-[(1R,3R,4S,5R)-1,4,8-trimethyl-2,9-dioxabicyclo[3.3.1]non-7-en-3-yl]hepta-2,4-dien-1-ylidene}-2H-pyrrole-2,4(3H)-dione, PROTOPORPHYRIN IX CONTAINING FE, TamI | | Authors: | Newmister, S.A, Srivastava, K.R, Espinoza, R.V, Haatveit, K.C, Khatri, Y, Martini, R.M, Garcia-Borras, M, Podust, L.M, Houk, K.N, Sherman, D.H. | | Deposit date: | 2020-06-03 | | Release date: | 2021-06-09 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Molecular Basis of Iterative C─H Oxidation by TamI, a Multifunctional P450 monooxygenase from the Tirandamycin Biosynthetic Pathway.
Acs Catalysis, 10, 2020
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6YQ8
 | | Crystal structure of native Phycocyanin from T. elongatus in spacegroup P63 at 1.8 Angstroms | | Descriptor: | 1,2-ETHANEDIOL, C-phycocyanin alpha chain, C-phycocyanin beta chain, ... | | Authors: | Feiler, C.G, Falke, S, Sarrou, I. | | Deposit date: | 2020-04-16 | | Release date: | 2021-01-20 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | C-phycocyanin as a highly attractive model system in protein crystallography: unique crystallization properties and packing-diversity screening.
Acta Crystallogr D Struct Biol, 77, 2021
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19HC
 | | NINE-HAEM CYTOCHROME C FROM DESULFOVIBRIO DESULFURICANS ATCC 27774 | | Descriptor: | ACETATE ION, PROTEIN (NINE-HAEM CYTOCHROME C), PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Matias, P.M, Coelho, R, Pereira, I.A.C, Coelho, A.V, Thompson, A.W, Sieker, L, Gall, J.L, Carrondo, M.A. | | Deposit date: | 1998-12-01 | | Release date: | 1999-12-01 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The primary and three-dimensional structures of a nine-haem cytochrome c from Desulfovibrio desulfuricans ATCC 27774 reveal a new member of the Hmc family.
Structure Fold.Des., 7, 1999
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6QKN
 | | Structure of the azide-inhibited form of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae | | Descriptor: | AZIDE ION, CALCIUM ION, Cytochrome-c peroxidase, ... | | Authors: | Carvalho, A.L, Romao, M.J, Pauleta, S, Nobrega, C. | | Deposit date: | 2019-01-29 | | Release date: | 2020-02-19 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure of the mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae
To Be Published
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8TAR
 | | APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD | | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | | Deposit date: | 2023-06-27 | | Release date: | 2023-09-27 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
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5KE0
 | | Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers | | Descriptor: | 1-[3-(2-methylpyridin-4-yl)-1~{H}-pyrazolo[4,3-c]pyridin-6-yl]-3-(phenylmethyl)urea, Mitogen-activated protein kinase 1, SULFATE ION | | Authors: | Hruza, A, Lim, J. | | Deposit date: | 2016-06-09 | | Release date: | 2016-07-06 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers.
J.Med.Chem., 59, 2016
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6FU3
 | | Structure of the mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae | | Descriptor: | CALCIUM ION, HEME C, Protein CcpR | | Authors: | Carvalho, A.L, Romao, M.J, Pauleta, S, Nobrega, C. | | Deposit date: | 2018-02-26 | | Release date: | 2019-03-13 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of the mixed-valence, active form, of cytochrome c peroxidase from obligate human pathogenic bacterium Neisseria gonorrhoeae
To Be Published
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6YYJ
 | | Crystal structure of native Phycocyanin from T. elongatus in spacegroup P21212 at 2.1 Angstroms | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[5-[[(3~{R},4~{R})-3-ethyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(~{Z})-(4-ethyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid, C-phycocyanin alpha chain, ... | | Authors: | Feiler, C.G, Falke, S, Sarrou, I. | | Deposit date: | 2020-05-05 | | Release date: | 2021-01-20 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | C-phycocyanin as a highly attractive model system in protein crystallography: unique crystallization properties and packing-diversity screening.
Acta Crystallogr D Struct Biol, 77, 2021
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8EBN
 | | Structure of KLHDC2-EloB/C tetrameric assembly | | Descriptor: | Elongin-B, Elongin-C, Kelch domain-containing protein 2 | | Authors: | Scott, D.C, Schulman, B.A. | | Deposit date: | 2022-08-31 | | Release date: | 2023-02-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.
Mol.Cell, 83, 2023
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6PFV
 | | Structure of S. venezuelae RisG-WhiG-c-di-GMP complex: orthorhombic crystal form | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), AmfC protein, RNA polymerase sigma factor | | Authors: | Schumacher, M.A. | | Deposit date: | 2019-06-22 | | Release date: | 2019-11-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | c-di-GMP Arms an Anti-sigma to Control Progression of Multicellular Differentiation in Streptomyces.
Mol.Cell, 77, 2020
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5NGX
 | | The 1.06 A resolution structure of the L16G mutant of ferric cytochrome c prime from Alcaligenes xylosoxidans, complexed with nitrite | | Descriptor: | Cytochrome c', GLYCEROL, HEME C, ... | | Authors: | Strange, R, Hough, M, Kekelli, D, Horrell, S, Moreno Chicano, T. | | Deposit date: | 2017-03-20 | | Release date: | 2018-05-16 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Distinguishing Nitro vs Nitrito Coordination in Cytochrome c' Using Vibrational Spectroscopy and Density Functional Theory.
Inorg.Chem., 56, 2017
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8K3G
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5NC0
 | | The 0.91 A resolution structure of the L16G mutant of cytochrome c prime from Alcaligenes xylosoxidans, complexed with nitric oxide | | Descriptor: | 1,2-ETHANEDIOL, Cytochrome c', HEME C, ... | | Authors: | Strange, R, Hough, M, Antonyuk, S, Rustage, N. | | Deposit date: | 2017-03-02 | | Release date: | 2018-01-10 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (0.91 Å) | | Cite: | Distinguishing Nitro vs Nitrito Coordination in Cytochrome c' Using Vibrational Spectroscopy and Density Functional Theory.
Inorg Chem, 56, 2017
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8HN3
 | | Soluble domain of cytochrome c-556 from Chlorobaculum tepidum | | Descriptor: | ACETATE ION, Cytochrome c-556, GLYCEROL, ... | | Authors: | Kishimoto, H, Azai, C, Yamamoto, T, Mutoh, R, Nakaniwa, T, Tanaka, H, Kurisu, G, Oh-oka, H. | | Deposit date: | 2022-12-07 | | Release date: | 2023-07-05 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Soluble domains of cytochrome c-556 and Rieske iron-sulfur protein from Chlorobaculum tepidum: Crystal structures and interaction analysis.
Curr Res Struct Biol, 5, 2023
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7TBA
 | | Pentraxin - ligand complex | | Descriptor: | C-reactive protein, CALCIUM ION, [3-(dibutylamino)propyl]phosphonic acid | | Authors: | Shing, K.S.C.T, Morton, C.J, Parker, M.W. | | Deposit date: | 2021-12-21 | | Release date: | 2022-10-19 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
Embo Mol Med, 15, 2023
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7T6X
 | | Cryo-EM structure of full-length hepatitis C virus E1E2 glycoprotein in complex with AR4A, AT12009, and IGH505 Fabs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, AR4A Fab, ... | | Authors: | Torrents de la Pena, A, Ward, A.B, Eshun-Wilson, L, Lander, G.C. | | Deposit date: | 2021-12-14 | | Release date: | 2022-11-02 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.83 Å) | | Cite: | Structure of the hepatitis C virus E1E2 glycoprotein complex.
Science, 378, 2022
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5K0U
 | | CryoEM structure of the full virion of a human rhinovirus C | | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | | Authors: | Liu, Y, Hill, M.G, Klose, T, Chen, Z, Watters, K.E, Jiang, W, Palmenberg, A.C, Rossmann, M.G. | | Deposit date: | 2016-05-17 | | Release date: | 2016-07-13 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (2.79 Å) | | Cite: | Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5JZG
 | | CryoEM structure of the native empty particle of a human rhinovirus C | | Descriptor: | Capsid protein VP0, Capsid protein VP1, Capsid protein VP3 | | Authors: | Liu, Y, Hill, M.G, Klose, T, Chen, Z, Watters, K.E, Jiang, W, Palmenberg, A.C, Rossmann, M.G. | | Deposit date: | 2016-05-16 | | Release date: | 2016-07-13 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.16 Å) | | Cite: | Atomic structure of a rhinovirus C, a virus species linked to severe childhood asthma.
Proc.Natl.Acad.Sci.USA, 113, 2016
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7B3Q
 | | Crystal structure of c-MET bound by compound 1 | | Descriptor: | 1-(phenylmethyl)-5~{H}-pyrrolo[3,2-c]pyridin-4-one, Hepatocyte growth factor receptor, SULFATE ION | | Authors: | Collie, G.W. | | Deposit date: | 2020-12-01 | | Release date: | 2020-12-09 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
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6SUY
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6CAM
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7MIE
 | | Crystal structure of the Borreliella burgdorferi PlzA protein in complex with c-di-GMP | | Descriptor: | 1,2-ETHANEDIOL, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CHLORIDE ION, ... | | Authors: | Davies, C, Singh, A. | | Deposit date: | 2021-04-16 | | Release date: | 2021-06-30 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | High-resolution crystal structure of the Borreliella burgdorferi PlzA protein in complex with c-di-GMP: new insights into the interaction of c-di-GMP with the novel xPilZ domain.
Pathog Dis, 79, 2021
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8TAU
 | | APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB | | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G. | | Deposit date: | 2023-06-27 | | Release date: | 2023-09-27 | | Last modified: | 2023-12-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
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1M39
 | | Solution structure of the C-terminal fragment (F86-I165) of the human centrin 2 in calcium saturated form | | Descriptor: | Caltractin, isoform 1 | | Authors: | Matei, E, Miron, S, Blouquit, Y, Duchambon, P, Durussel, P, Cox, J.A, Craescu, C.T. | | Deposit date: | 2002-06-27 | | Release date: | 2003-03-25 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | C-terminal half of human centrin 2 behaves like a regulatory EF-hand domain
Biochemistry, 42, 2003
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7S9Z
 | | Helicobacter Hepaticus CcsBA Closed Conformation | | Descriptor: | Cytochrome c biogenesis protein, HEME B/C, PHOSPHATIDYLETHANOLAMINE | | Authors: | Mendez, D.L, Lowder, E.P, Tillman, D.E, Sutherland, M.C, Collier, A.L, Rau, M.J, Fitzpatrick, J.A, Kranz, R.G. | | Deposit date: | 2021-09-21 | | Release date: | 2021-12-22 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (4.14 Å) | | Cite: | Cryo-EM of CcsBA reveals the basis for cytochrome c biogenesis and heme transport.
Nat.Chem.Biol., 18, 2022
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