5G2N

X-ray structure of PI3Kinase Gamma in complex with Copanlisib

Summary for 5G2N

Entry DOI	10.2210/pdb5g2n/pdb
Descriptor	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, 2-azanyl-~{N}-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide, SULFATE ION, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm : P48736
Total number of polymer chains	1
Total formula weight	112675.26
Authors	Schaefer, M.,Scott, W.J.,Hentemann, M.F.,Rowley, R.B.,Bull, C.O.,Jenkins, S.,Bullion, A.M.,Johnson, J.,Redman, A.,Robbins, A.H.,Esler, W.,Fracasso, R.P.,Garrison, T.,Hamilton, M.,Michels, M.,Wood, J.E.,Wilkie, D.P.,Xiao, H.,Levy, J.,Liu, N.,Stasik, E.,Brands, M.,Lefranc, J. (deposition date: 2016-04-11, release date: 2016-04-20, Last modification date: 2016-08-10)
Primary citation	Schaefer, M.,Scott, W.J.,Hentemann, M.F.,Rowley, R.B.,Bull, C.O.,Jenkins, S.,Bullion, A.M.,Johnson, J.,Redman, A.,Robbins, A.H.,Esler, W.,Fracasso, R.P.,Garrison, T.,Hamilton, M.,Michels, M.,Wood, J.E.,Wilkie, D.P.,Xiao, H.,Levy, J.,Liu, N.,Stasik, E.,Brands, M.,Lefranc, J. Discovery and Sar of Novel 2,3-Dihydroimidazo(1,2-C)Quinazoline Pi3K Inhibitors: Identification of Copanlisib (Bay 80-6946) Chemmedchem, 11:1517-, 2016 Cited by PubMed: 27310202 DOI: 10.1002/CMDC.201600148 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.68 Å)

Structure validation