5G2N

X-ray structure of PI3Kinase Gamma in complex with Copanlisib

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM	polymer	980	112098.7	1	UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454)	HOMO SAPIENS (HUMAN)
2	B (A)	2-azanyl-~{N}-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide	non-polymer		480.5	1	Chemie (6E2)
3	C (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	D (A)	water	water		18.0	11	Chemie (HOH)

Sequence modifications

A: 144 - 1102 (UniProt: P48736)

PDB	External Database	Details
Met 139	-	expression tag
Leu 140	-	expression tag
Leu 141	-	expression tag
Gly 142	-	expression tag
Ser 143	-	expression tag
Glu 1103	-	expression tag
Phe 1104	-	expression tag
Gly 1105	-	expression tag
Leu 1106	-	expression tag
Val 1107	-	expression tag
Pro 1108	-	expression tag
Arg 1109	-	expression tag
Gly 1110	-	expression tag
Ser 1111	-	expression tag
Gly 1112	-	expression tag
His 1113	-	expression tag
His 1114	-	expression tag
His 1115	-	expression tag
His 1116	-	expression tag
His 1117	-	expression tag
His 1118	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	112098.7
Non-Polymers*	Number of molecules	2
	Total formula weight	576.6
All*	Total formula weight	112675.3

*Water molecules are not included.