6SUY

Yeast cytochrome c in complex with an octa-anionic calix[4]arene

Summary for 6SUY

• Entry DOI: 10.2210/pdb6suy/pdb
• Descriptor: Cytochrome c iso-1, HEME C, octa-anionic calix[4]arene, ... (6 entities in total)
• Functional Keywords: protein recognition, porous assembly, supramolecular scaffolds, molecular glue, oxidoreductase
• Biological source: Saccharomyces cerevisiae (Baker's yeast)
• Total number of polymer chains: 2
• Total formula weight: 27800.61

Authors

Alex, J.M.,Crowley, P.B. (deposition date: 2019-09-17, release date: 2020-01-15, Last modification date: 2024-11-06)

Primary citation

Alex, J.M.,Brancatelli, G.,Volpi, S.,Bonaccorso, C.,Casnati, A.,Geremia, S.,Crowley, P.B.
Probing the determinants of porosity in protein frameworks: co-crystals of cytochrome c and an octa-anionic calix[4]arene.
Org.Biomol.Chem., 18:211-214, 2020

PubMed Abstract: Sulfonato-calix[n]arenes (sclxn) are promising tools to generate crystalline protein frameworks. We report, for the first time, a lower rim functionalised octa-anionic calix[4]arene (sclx4mc) in complex with proteins. Two crystal structures of sclx4mc bound to yeast or horse heart cytochrome c (cytc) are described. Highly porous honeycomb or tubular assemblies were obtained with yeast or horse cytc, respectively. Related frameworks were obtained previously with sclx8 and sclx6 but not with sclx4, suggesting that the ligand charge is a determining factor.

PubMed: 31808772
DOI: 10.1039/c9ob02275a

Experimental method

X-RAY DIFFRACTION (1.75 Å)