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7RNU
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BU of 7rnu by Molmil
nSH2 domain of p85-beta subunit of phosphatidylinositol 3-kinase in complex with an actin peptide with phosphorylated tyrosine 53
Descriptor: 1,2-ETHANEDIOL, Actin, alpha skeletal muscle, ...
Authors:Dai, S, Horton, J.R, Cheng, X.
Deposit date:2021-07-29
Release date:2021-08-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Functional Analysis of a Major Tyrosine Phosphorylation Site on Actin
To Be Published
7R8X
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BU of 7r8x by Molmil
Crystal Structure of the LNK SH2 Domain in Complex with an EPOR pY454 Phosphopeptide
Descriptor: EPOR pY454 phosphopeptide, SH2B adapter protein 3
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2021-06-27
Release date:2021-10-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.
Nat Commun, 12, 2021
7R8W
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BU of 7r8w by Molmil
Crystal Structure of the LNK SH2 Domain in Complex with a JAK2 pY813 Phosphopeptide
Descriptor: JAK2 pY813 phosphopeptide, SH2B adapter protein 3
Authors:Morris, R, Kershaw, N.J, Babon, J.J.
Deposit date:2021-06-27
Release date:2021-10-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.
Nat Commun, 12, 2021
5D0J
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BU of 5d0j by Molmil
Grb7 SH2 with inhibitor peptide
Descriptor: G7-TEdFP peptide, Growth factor receptor-bound protein 7, PHOSPHATE ION
Authors:Gunzburg, M.J, Watson, G.M, Wilce, J.A, Wilce, M.C.J.
Deposit date:2015-08-03
Release date:2016-06-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
7SA7
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BU of 7sa7 by Molmil
Crystal structure of the apo SH2 domains of Syk
Descriptor: Tyrosine-protein kinase SYK
Authors:Hobbs, H.T, Badroos, J, Gee, C.L, Kuriyan, J.
Deposit date:2021-09-22
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein Sci., 30, 2021
5DF6
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BU of 5df6 by Molmil
Crystal structure of PTPN11 tandem SH2 domains in complex with a TXNIP peptide
Descriptor: Tyrosine-protein phosphatase non-receptor type 11, UNKNOWN ATOM OR ION, txnip
Authors:Dong, A, Li, W, Tempel, W, Liu, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC)
Deposit date:2015-08-26
Release date:2015-09-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structural basis for the regulatory role of the PPxY motifs in the thioredoxin-interacting protein TXNIP.
Biochem.J., 473, 2016
5EEQ
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BU of 5eeq by Molmil
Grb7 SH2 with the G7-B1 bicyclic peptide inhibitor
Descriptor: Bicyclic Peptide Inhibitor, Growth factor receptor-bound protein 7, PHOSPHATE ION
Authors:Ambaye, N.D, Watson, G.M, Wilce, M.C.J, Wilce, G.M.
Deposit date:2015-10-23
Release date:2016-06-15
Last modified:2024-04-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
5EEL
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BU of 5eel by Molmil
Grb7 SH2 with bicyclic peptide inhibitor
Descriptor: Bicyclic Peptide Inhibitor, FORMIC ACID, Growth factor receptor-bound protein 7, ...
Authors:Watson, G.M, Gunzburg, M.J, Wilce, M.C.J, Wilce, J.A.
Deposit date:2015-10-23
Release date:2016-06-15
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7.
Sci Rep, 6, 2016
7T1K
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BU of 7t1k by Molmil
Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ...
Authors:Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
7T1L
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BU of 7t1l by Molmil
Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide
Descriptor: CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ...
Authors:Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
7T1U
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BU of 7t1u by Molmil
Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide
Descriptor: Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION
Authors:Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S.
Deposit date:2021-12-02
Release date:2022-08-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Engineered SH2 Domains for Targeted Phosphoproteomics.
Acs Chem.Biol., 17, 2022
4F59
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BU of 4f59 by Molmil
Triple mutant Src SH2 domain
Descriptor: Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4FBN
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BU of 4fbn by Molmil
Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Authors:Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M.
Deposit date:2012-05-23
Release date:2012-10-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
Structure, 20, 2012
4EIH
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BU of 4eih by Molmil
Crystal structure of Arg SH2 domain
Descriptor: Abelson tyrosine-protein kinase 2, CHLORIDE ION
Authors:Liu, W, MacGrath, S.M, Koleske, A.J, Boggon, T.J.
Deposit date:2012-04-05
Release date:2013-04-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Two Amino Acid Residues Confer Different Binding Affinities of Abelson Family Kinase Src Homology 2 Domains for Phosphorylated Cortactin.
J.Biol.Chem., 289, 2014
4F5A
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BU of 4f5a by Molmil
Triple mutant Src SH2 domain bound to phosphate ion
Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4F5B
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BU of 4f5b by Molmil
Triple mutant Src SH2 domain bound to phosphotyrosine
Descriptor: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src
Authors:Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S.
Deposit date:2012-05-12
Release date:2012-10-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Superbinder SH2 Domains Act as Antagonists of Cell Signaling.
Sci.Signal., 5, 2012
4EY0
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BU of 4ey0 by Molmil
Structure of tandem SH2 domains from PLCgamma1
Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Authors:Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M.
Deposit date:2012-05-01
Release date:2012-10-31
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation.
Structure, 20, 2012
2QMS
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BU of 2qms by Molmil
Crystal structure of a signaling molecule
Descriptor: Growth factor receptor-bound protein 7, SULFATE ION
Authors:Porter, C.J, Wilce, M.C, Wilce, J.A.
Deposit date:2007-07-16
Release date:2008-07-22
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation.
Bmc Struct.Biol., 7, 2007
2RSY
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BU of 2rsy by Molmil
Solution structure of the SH2 domain of Csk in complex with a phosphopeptide from Cbp
Descriptor: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Tyrosine-protein kinase CSK
Authors:Tanaka, H, Akagi, K, Oneyama, C, Tanaka, M, Sasaki, Y, Kanou, T, Lee, Y, Yokogawa, D, Debenecker, M, Nakagawa, A, Okada, M, Ikegami, T.
Deposit date:2012-09-10
Release date:2013-04-10
Last modified:2019-12-25
Method:SOLUTION NMR
Cite:Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
J.Biol.Chem., 288, 2013
2RMX
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BU of 2rmx by Molmil
Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A
Descriptor: NKG2-A/NKG2-B type II integral membrane protein, Tyrosine-protein phosphatase non-receptor type 6
Authors:Kasai, T, Koshiba, S, Inoue, M, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-11-30
Release date:2008-12-02
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1
To be Published
2PNB
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BU of 2pnb by Molmil
STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN
Authors:Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D.
Deposit date:1992-06-30
Release date:1994-01-31
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.
Nature, 358, 1992
2PLE
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BU of 2ple by Molmil
NUCLEAR MAGNETIC RESONANCE STRUCTURE OF AN SH2 DOMAIN OF PHOSPHOLIPASE C-GAMMA1 COMPLEXED WITH A HIGH AFFINITY BINDING PEPTIDE
Descriptor: PHOSPHOLIPASE C GAMMA-1, C-TERMINAL SH2 DOMAIN, PHOSPHOPEPTIDE FROM PDGF
Authors:Pascal, S.M, Singer, A.U, Gish, G, Yamazaki, T, Shoelson, S.E, Pawson, T, Kay, L.E, Forman-Kay, J.D.
Deposit date:1994-08-19
Release date:1995-01-26
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of an SH2 domain of phospholipase C-gamma 1 complexed with a high affinity binding peptide.
Cell(Cambridge,Mass.), 77, 1994
2PNA
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BU of 2pna by Molmil
STRUCTURE OF AN SH2 DOMAIN OF THE P85 ALPHA SUBUNIT OF PHOSPHATIDYLINOSITOL-3-OH KINASE
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE P85-ALPHA SUBUNIT N-TERMINAL SH2 DOMAIN
Authors:Booker, G.W, Breeze, A.L, Downing, A.K, Panayotou, G, Gout, I, Waterfield, M.D, Campbell, I.D.
Deposit date:1992-06-30
Release date:1994-01-31
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.
Nature, 358, 1992
2ROR
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BU of 2ror by Molmil
Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76
Descriptor: 15-meric peptide from Lymphocyte cytosolic protein 2, Proto-oncogene vav
Authors:Tanaka, M, Kasai, T, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2008-04-08
Release date:2009-04-21
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the VAV1 SH2 domain complexed with a tyrosine-phosphorylated peptide from SLP76
To be Published
2RVF
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BU of 2rvf by Molmil
Solution NMR structure of Monosiga brevicollis CRK/CRKL homolog (crka1) SH2 domain
Descriptor: Predicted protein
Authors:Kasai, T, Pawlak, J, Imamoto, A, Kigawa, T.
Deposit date:2015-09-24
Release date:2016-09-21
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:A pre-metazoan origin of the CRK gene family and co-opted signaling network
Sci Rep, 6, 2016

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數據於2024-06-26公開中

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