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4FV8	Crystal Structure of the ERK2 complexed with E63 Descriptor: 1,2-ETHANEDIOL, 6-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]-5-(phenylamino)pyrimidin-2-yl}amino)-1,2-dihydro-3H-indazol-3-one, Mitogen-activated protein kinase 1, ... Authors: Kang, Y.N, Stuckey, J.A, Xie, X. Deposit date: 2012-06-29 Release date: 2012-08-29 Last modified: 2014-09-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structure of the ERK2 complexed with E63 TO BE PUBLISHED
3RZ3	Human Cdc34 E2 in complex with CC0651 inhibitor Descriptor: 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin-conjugating enzyme E2 R1 Authors: Ceccarelli, D.F, Webb, D.R, Sicheri, F. Deposit date: 2011-05-11 Release date: 2011-07-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.3 Å) Cite: An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme Cell(Cambridge,Mass.), 145, 2011
3RYI	GDP-Tubulin: rb3 stathmin-like domain complex Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Nawrotek, A, Knossow, M, Gigant, B. Deposit date: 2011-05-11 Release date: 2011-10-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.4 Å) Cite: The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin. J.Mol.Biol., 412, 2011
4FYQ	Human aminopeptidase N (CD13) Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ... Authors: Wong, A.H, Rini, J.M. Deposit date: 2012-07-05 Release date: 2012-09-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
4G2M	Structure of a Lys-HCT mutant from Coffea canephora (Crystal form 2) Descriptor: Hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase Authors: Lallemand, L.A, McCarthy, J.G, McCarthy, A.A. Deposit date: 2012-07-12 Release date: 2012-08-01 Last modified: 2012-11-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: A structural basis for the biosynthesis of the major chlorogenic acids found in coffee. Plant Physiol., 160, 2012
4G0B	Structure of native HCT from Coffea canephora Descriptor: Hydroxycinnamoyl-CoA shikimate/quinate hydroxycinnamoyltransferase, SULFATE ION Authors: Lallemand, L.A, McCarthy, J.G, McCarthy, A.A. Deposit date: 2012-07-09 Release date: 2012-08-01 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3 Å) Cite: A structural basis for the biosynthesis of the major chlorogenic acids found in coffee. Plant Physiol., 160, 2012
4GFJ	Crystal structure of Topo-78, an N-terminal 78kDa fragment of topoisomerase V Descriptor: GLYCEROL, Topoisomerase V, ZINC ION Authors: Rajan, R, Prasad, R, Taneja, B, Wilson, S.H, Mondragon, A. Deposit date: 2012-08-03 Release date: 2012-12-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.91 Å) Cite: Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies. Nucleic Acids Res., 41, 2013
4G1F	Crystal Structure of human Dipeptidyl Peptidase IV in complex with a pyridopyrimidinedione analogue Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-amino-6-(aminomethyl)-5-(2-bromophenyl)-1,3-dimethylpyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione, ... Authors: Skene, R.J, Gwaltney, S.L. Deposit date: 2012-07-10 Release date: 2013-02-27 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
4FV3	Crystal Structure of the ERK2 complexed with EK6 Descriptor: 1,2-ETHANEDIOL, Mitogen-activated protein kinase 1, SULFATE ION, ... Authors: Kang, Y.N, Stuckey, J.A, Xie, X. Deposit date: 2012-06-29 Release date: 2012-08-29 Last modified: 2014-09-24 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal Structure of the ERK2 complexed with EK6 TO BE PUBLISHED
4FYS	Human aminopeptidase N (CD13) in complex with angiotensin IV Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ... Authors: Wong, A.H, Rini, J.M. Deposit date: 2012-07-05 Release date: 2012-09-05 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.01 Å) Cite: The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing. J.Biol.Chem., 287, 2012
4I29	Binary complex of mouse TdT with ssDNA and Mn++ Descriptor: 5'-D(*AP*AP*(8BA)P*AP*A)-3', DNA nucleotidylexotransferase, MANGANESE (II) ION, ... Authors: Gouge, J, Delarue, M. Deposit date: 2012-11-21 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
3S1Z	Crystal structure of acetamide bound Xanthomonas campestri OleA Descriptor: 3-oxoacyl-[ACP] synthase III, ACETAMIDE Authors: Goblirsch, B.R, Wilmot, C.M. Deposit date: 2011-05-16 Release date: 2012-05-16 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.0547 Å) Cite: Crystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty Acids. Biochemistry, 51, 2012
4I5H	Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor Descriptor: Mitogen-activated protein kinase 1, N-{3-[2-(cyclopropylamino)quinazolin-6-yl]-4-methylphenyl}-3-(trifluoromethyl)benzamide Authors: Hari, S.B, Maly, D.J, Merritt, E.A. Deposit date: 2012-11-28 Release date: 2013-07-10 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Sequence determinants of a specific inactive protein kinase conformation. Chem.Biol., 20, 2013
3S36	Structural basis for the function of two anti-VEGF receptor antibodies Descriptor: 1121B heavy chain, 1121B light chain, Vascular endothelial growth factor receptor 2 Authors: Franklin, M.C. Deposit date: 2011-05-17 Release date: 2011-08-24 Last modified: 2017-11-08 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies. Structure, 19, 2011
3RYC	Tubulin: RB3 stathmin-like domain complex Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Nawrotek, A, Knossow, M, Gigant, B. Deposit date: 2011-05-11 Release date: 2011-10-05 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The Determinants That Govern Microtubule Assembly from the Atomic Structure of GTP-Tubulin. J.Mol.Biol., 412, 2011
3S90	Human vinculin head domain Vh1 (residues 1-252) in complex with murine talin (VBS33; residues 1512-1546) Descriptor: Talin-1, Vinculin Authors: Yogesha, S.D, Sharff, A, Bricogne, G, Izard, T. Deposit date: 2011-05-31 Release date: 2011-06-22 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.97 Å) Cite: Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin. Protein Sci., 20, 2011
3S9O	The Focal Adhesion Targeting (FAT) domain of the Focal Adhesion Kinase showing N-terminal interactions in cis Descriptor: CHLORIDE ION, Focal adhesion kinase 1, SODIUM ION Authors: Arold, S.T. Deposit date: 2011-06-01 Release date: 2012-06-06 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells. J.Biol.Chem., 290, 2015
3RTW	Nitrowillardiine bound to the ligand binding domain of GluA2 Descriptor: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION Authors: Ahmed, A.H, Oswald, R.E. Deposit date: 2011-05-04 Release date: 2011-05-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.095 Å) Cite: Mechanisms of Modal Activation of GluA3 Receptors. Mol.Pharmacol., 80, 2011
4HUM	MATE transporter NorM-NG in complex with ethidium and monobody Descriptor: ETHIDIUM, Multidrug efflux protein, Protein B Authors: Lu, M. Deposit date: 2012-11-02 Release date: 2013-02-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.49 Å) Cite: Structures of a Na+-coupled, substrate-bound MATE multidrug transporter. Proc.Natl.Acad.Sci.USA, 110, 2013
4I2A	Binary complex of mouse TdT with ssDNA in absence of divalent transition metal ion Descriptor: 5'-D(*AP*AP*(BRU)P*AP*A)-3', DNA nucleotidylexotransferase, MAGNESIUM ION, ... Authors: Gouge, J, Delarue, M. Deposit date: 2012-11-21 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
4I2G	Binary complex of mouse TdT with ssDNA Descriptor: 5'-D(P*AP*AP*AP*AP*A)-3', COBALT (II) ION, DNA nucleotidylexotransferase, ... Authors: Gouge, J, Delarue, M. Deposit date: 2012-11-21 Release date: 2013-07-24 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism. J.Mol.Biol., 425, 2013
3SA0	Complex of ERK2 with norathyriol Descriptor: Mitogen-activated protein kinase 1, SULFATE ION, norathyriol Authors: Kurinov, I, Malakhova, M. Deposit date: 2011-06-02 Release date: 2011-12-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5947 Å) Cite: Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases. Cancer Res., 72, 2012
4I4E	Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound. Descriptor: Focal adhesion kinase 1, [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone Authors: Skene, R.J, Hosfield, D.J. Deposit date: 2012-11-27 Release date: 2013-03-06 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structure-based discovery of cellular-active allosteric inhibitors of FAK. Bioorg.Med.Chem.Lett., 23, 2013
4I7Y	Crystal Structure of Human Alpha Thrombin in Complex with a 27-mer Aptamer Bound to Exosite II Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, DNA (27-MER), ... Authors: Pica, A, Russo Krauss, I, Merlino, A, Mazzarella, L, Sica, F. Deposit date: 2012-12-01 Release date: 2013-10-16 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Duplex-quadruplex motifs in a peculiar structural organization cooperatively contribute to thrombin binding of a DNA aptamer. Acta Crystallogr.,Sect.D, 69, 2013
3SDL	Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza B virus, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2 Descriptor: Non-structural protein 1, Ubiquitin-like protein ISG15 Authors: Guan, R, Ma, L.-C, Krug, R.M, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) Deposit date: 2011-06-09 Release date: 2011-07-20 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.29 Å) Cite: Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus. Proc.Natl.Acad.Sci.USA, 108, 2011

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