6A5Z
| Crystal structure of human FXR/RXR-LBD heterodimer bound to HNC180 and 9cRA and SRC1 | Descriptor: | (9cis)-retinoic acid, 2-[(1R,5S)-9-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-3-azabicyclo[3.3.1]nonan-3-yl]-1,3-benzothiazole-6-carboxylic acid, Bile acid receptor, ... | Authors: | Wang, N, Liu, J. | Deposit date: | 2018-06-25 | Release date: | 2018-10-10 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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2LM5
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6A60
| Crystal structure of human FXR/RXR-LBD heterodimer bound to GW4064 and 9cRA and SRC1 | Descriptor: | (9cis)-retinoic acid, 3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1-methylethyl)isoxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid, Bile acid receptor, ... | Authors: | Wang, N, Liu, J. | Deposit date: | 2018-06-25 | Release date: | 2018-10-10 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.05 Å) | Cite: | Ligand binding and heterodimerization with retinoid X receptor alpha (RXR alpha ) induce farnesoid X receptor (FXR) conformational changes affecting coactivator binding J. Biol. Chem., 293, 2018
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5U4M
| RTA-V1C7-G29R-no_salt | Descriptor: | CHLORIDE ION, Ricin, V1C7 VHH antibody | Authors: | Rudolph, M.J, Mantis, N. | Deposit date: | 2016-12-05 | Release date: | 2017-12-13 | Last modified: | 2019-12-11 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies. Proteins, 85, 2017
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5U4L
| RTA-V1C7_G29R-high-salt | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, PHOSPHATE ION, ... | Authors: | Rudolph, M.J, Mantis, N. | Deposit date: | 2016-12-05 | Release date: | 2017-12-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Using homology modeling to interrogate binding affinity in neutralization of ricin toxin by a family of single domain antibodies. Proteins, 85, 2017
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5TQU
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor | Descriptor: | 2-[2-[[3-(1~{H}-benzimidazol-2-ylamino)propylamino]methyl]-4,6-bis(chloranyl)indol-1-yl]ethanol, GLYCEROL, METHIONINE, ... | Authors: | Barros-Alvarez, X, Hol, W.G.J. | Deposit date: | 2016-10-24 | Release date: | 2017-04-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis. ACS Infect Dis, 3, 2017
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3HQU
| PHD2:Fe:UN9:partial HIF1-alpha substrate complex | Descriptor: | Egl nine homolog 1, FE (II) ION, Hypoxia-inducible factor 1 alpha, ... | Authors: | Chowdhury, R, McDonough, M.A, Schofield, C.J. | Deposit date: | 2009-06-08 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009
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4JHN
| The crystal structure of the RPGR RCC1-like domain | Descriptor: | X-linked retinitis pigmentosa GTPase regulator | Authors: | Waetzlich, D, Vetter, I, Wittinghofer, A, Ismail, S. | Deposit date: | 2013-03-05 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo. Embo Rep., 14, 2013
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1KG9
| Structure of a "mock-trapped" early-M intermediate of bacteriorhosopsin | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, RETINAL, bacteriorhodopsin | Authors: | Facciotti, M.T, Rouhani, S, Burkard, F.T, Betancourt, F.M, Downing, K.H, Rose, R.B, McDermott, G, Glaeser, R.M. | Deposit date: | 2001-11-26 | Release date: | 2001-12-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure of an early intermediate in the M-state phase of the bacteriorhodopsin photocycle. Biophys.J., 81, 2001
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5UZ9
| Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex | Descriptor: | Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ... | Authors: | Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. | Deposit date: | 2017-02-25 | Release date: | 2017-04-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell, 169, 2017
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4JHP
| The crystal structure of the RPGR RCC1-like domain in complex with PDE6D | Descriptor: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, X-linked retinitis pigmentosa GTPase regulator | Authors: | Waetzlich, D, Vetter, I, Wittinghofer, A, Ismail, S. | Deposit date: | 2013-03-05 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The interplay between RPGR, PDE-delta and Arl2/3 regulate the ciliary targeting of farnesylated cargo. Embo Rep., 14, 2013
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2MX2
| UBX-L domain of VCIP135 | Descriptor: | Deubiquitinating protein VCIP135 | Authors: | Iwazu, T, Murayama, S, Igarashi, R, Hrioaki, H, Shirakawa, M, Tochio, H. | Deposit date: | 2014-12-07 | Release date: | 2016-07-13 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structure and interaction mode of the UBX-L domain of VCIP135 determined by solution NMR spectroscopy To be Published
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3HQR
| PHD2:Mn:NOG:HIF1-alpha substrate complex | Descriptor: | Egl nine homolog 1, Hypoxia-inducible factor 1 alpha, MANGANESE (II) ION, ... | Authors: | Chowdhury, R, McDonough, M.A, Schofield, C.J. | Deposit date: | 2009-06-08 | Release date: | 2009-07-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases Structure, 17, 2009
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5YXD
| A ligand F binding to FXR | Descriptor: | Bile acid receptor, Peptide from Nuclear receptor coactivator, ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethylpyridine-3,5-dicarboxylate | Authors: | Yi, L, Yong, L. | Deposit date: | 2017-12-05 | Release date: | 2019-03-13 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | A ligand F binding to FXR To Be Published
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5SZG
| Structure of the bMERB domain of Mical-3 | Descriptor: | DI(HYDROXYETHYL)ETHER, Protein-methionine sulfoxide oxidase MICAL3 | Authors: | Rai, A, Oprisko, A, Campos, J, Fu, Y, Friese, T, Itzen, A, Goody, R.S, Gazdag, E.M, Mueller, M.P. | Deposit date: | 2016-08-14 | Release date: | 2016-08-24 | Last modified: | 2017-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. Elife, 5, 2016
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4U8F
| Crystal structure of 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase complexed with a tartrate | Descriptor: | L(+)-TARTARIC ACID, Putative uncharacterized protein gbs1892 | Authors: | Maruyama, Y, Oiki, S, Takase, R, Mikami, B, Murata, K, Hashimoto, W. | Deposit date: | 2014-08-03 | Release date: | 2014-12-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Metabolic Fate of Unsaturated Glucuronic/Iduronic Acids from Glycosaminoglycans: MOLECULAR IDENTIFICATION AND STRUCTURE DETERMINATION OF STREPTOCOCCAL ISOMERASE AND DEHYDROGENASE. J.Biol.Chem., 290, 2015
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5Z12
| A structure of FXR/RXR | Descriptor: | (9cis)-retinoic acid, 1-methylethyl 3-[(3,4-difluorophenyl)carbonyl]-1,1-dimethyl-1,2,3,6-tetrahydroazepino[4,5-b]indole-5-carboxylate, Bile acid receptor, ... | Authors: | Lu, Y, Li, Y. | Deposit date: | 2017-12-23 | Release date: | 2018-07-04 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR J. Biol. Chem., 293, 2018
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4TRT
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4U8E
| Crystal structure of 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase from Streptococcus agalactiae | Descriptor: | Putative uncharacterized protein gbs1892 | Authors: | Maruyama, y, Oiki, S, Takase, R, Mikami, B, Murata, K, Hashimoto, W. | Deposit date: | 2014-08-03 | Release date: | 2015-01-21 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Metabolic Fate of Unsaturated Glucuronic/Iduronic Acids from Glycosaminoglycans: MOLECULAR IDENTIFICATION AND STRUCTURE DETERMINATION OF STREPTOCOCCAL ISOMERASE AND DEHYDROGENASE J.Biol.Chem., 290, 2015
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5WRD
| Crystal structure of LC3B in complex with FYCO1 LIR | Descriptor: | GLYCEROL, Microtubule-associated proteins 1A/1B light chain 3B, Peptide from FYVE and coiled-coil domain-containing protein 1 | Authors: | Sakurai, S, Ohto, U, Shimizu, T. | Deposit date: | 2016-12-01 | Release date: | 2017-03-29 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif Acta Crystallogr F Struct Biol Commun, 73, 2017
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2WZ9
| Crystal structure of the thioredoxin domain of human TXNL2 | Descriptor: | GLUTAREDOXIN-3 | Authors: | Vollmar, M, Johannson, C, Cocking, R, Pike, A.C.W, Muniz, J.R.C, Edwards, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Weigelt, J, Kavanagh, K.L. | Deposit date: | 2009-11-25 | Release date: | 2010-03-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal Structure of the Thioredoxin Domain of Human Txnl2 To be Published
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6CES
| Cryo-EM structure of GATOR1-RAG | Descriptor: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | Authors: | Shen, K, Huang, R.K, Brignole, E.J, Yu, Z, Sabatini, D.M. | Deposit date: | 2018-02-12 | Release date: | 2018-03-28 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes. Nature, 556, 2018
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1KG8
| X-ray structure of an early-M intermediate of bacteriorhodopsin | Descriptor: | 1-[2,6,10.14-TETRAMETHYL-HEXADECAN-16-YL]-2-[2,10,14-TRIMETHYLHEXADECAN-16-YL]GLYCEROL, RETINAL, bacteriorhodopsin | Authors: | Facciotti, M.T, Rouhani, S, Burkard, F.T, Betancourt, F.M, Downing, K.H, Rose, R.B, McDermott, G, Glaeser, R.M. | Deposit date: | 2001-11-26 | Release date: | 2001-12-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of an early intermediate in the M-state phase of the bacteriorhodopsin photocycle. Biophys.J., 81, 2001
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2KY5
| Solution structure of the PECAM-1 cytoplasmic tail with DPC | Descriptor: | Platelet endothelial cell adhesion molecule | Authors: | Lytle, B.L, Peterson, F.C, Volkman, B.F, Paddock, C, Newman, D.K, Center for Eukaryotic Structural Genomics (CESG) | Deposit date: | 2010-05-14 | Release date: | 2010-05-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Residues within a lipid-associated segment of the PECAM-1 cytoplasmic domain are susceptible to inducible, sequential phosphorylation. Blood, 117, 2011
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7LK3
| Crystal structure of untwinned human GABARAPL2 | Descriptor: | 1,2-ETHANEDIOL, Gamma-aminobutyric acid receptor-associated protein-like 2 | Authors: | Scicluna, K, Dewson, G, Czabotar, P.E, Birkinshaw, R.W. | Deposit date: | 2021-02-01 | Release date: | 2021-05-12 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A new crystal form of GABARAPL2. Acta Crystallogr.,Sect.F, 77, 2021
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