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6KNM
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BU of 6knm by Molmil
Apelin receptor in complex with single domain antibody
Descriptor: Apelin receptor,Rubredoxin,Apelin receptor, Single domain antibody JN241, ZINC ION
Authors:Ma, Y.B, Ding, Y, Song, X, Ma, X, Li, X, Zhang, N, Song, Y, Sun, Y, Shen, Y, Zhong, W, Hu, L.A, Ma, Y.L, Zhang, M.Y.
Deposit date:2019-08-06
Release date:2020-01-29
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-guided discovery of a single-domain antibody agonist against human apelin receptor.
Sci Adv, 6, 2020
7C4S
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BU of 7c4s by Molmil
Sphingosine-1-phosphate receptor 3 with a natural ligand.
Descriptor: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, ...
Authors:Iwata, S, Maeda, S, Luo, F, Nango, E, hirata, K, Asada, H.
Deposit date:2020-05-18
Release date:2021-06-09
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.
Sci Adv, 7, 2021
6KPC
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BU of 6kpc by Molmil
Crystal structure of an agonist bound GPCR
Descriptor: 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile, Cannabinoid receptor 2,Endolysin
Authors:Li, X.T, Hua, T, Wu, L.J, Makriyannis, A, Wu, M, Liu, Z.J.
Deposit date:2019-08-15
Release date:2020-02-12
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
7XOU
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BU of 7xou by Molmil
Structural insights into human brain gut peptide cholecystokinin receptors
Descriptor: CCK-8, Cholecystokinin receptor type A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Ding, Y, Zhang, H, Liao, Y, Chen, L, Ji, S.
Deposit date:2022-05-01
Release date:2022-07-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into human brain-gut peptide cholecystokinin receptors.
Cell Discov, 8, 2022
6KUY
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BU of 6kuy by Molmil
Crystal structure of the alpha2A adrenergic receptor in complex with a partial agonist
Descriptor: (2~{S})-4-fluoranyl-2-(1~{H}-imidazol-5-yl)-1-propan-2-yl-2,3-dihydroindole, Alpha2A adrenergic receptor, DI(HYDROXYETHYL)ETHER
Authors:Qu, L, Zhou, Q.T, Wu, D, Zhao, S.W.
Deposit date:2019-09-02
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structures of the alpha2A adrenergic receptor in complex with a partial agonist
To Be Published
5XSZ
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BU of 5xsz by Molmil
Crystal structure of zebrafish lysophosphatidic acid receptor LPA6
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lysophosphatidic acid receptor 6a,Endolysin,Lysophosphatidic acid receptor 6a
Authors:Taniguchi, R, Nishizawa, T, Ishitani, R, Nureki, O.
Deposit date:2017-06-16
Release date:2017-08-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6
Nature, 548, 2017
6LFL
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BU of 6lfl by Molmil
Crystal structure of a class A GPCR
Descriptor: 4-[[3,4-bis(oxidanylidene)-2-[[(1~{R})-1-(4-propan-2-ylfuran-2-yl)propyl]amino]cyclobuten-1-yl]amino]-~{N},~{N}-dimethyl-3-oxidanyl-pyridine-2-carboxamide, C-X-C chemokine receptor type 2,GlgA glycogen synthase,C-X-C chemokine receptor type 2
Authors:Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J.
Deposit date:2019-12-03
Release date:2020-09-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of CXC chemokine receptor 2 activation and signalling.
Nature, 585, 2020
8IHK
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BU of 8ihk by Molmil
Cryo-EM structure of HCA3-Gi complex with acifran (local)
Descriptor: (5~{S})-5-methyl-4-oxidanylidene-5-phenyl-furan-2-carboxylic acid, Soluble cytochrome b562,Hydroxycarboxylic acid receptor 3
Authors:Suzuki, S, Nishikawa, K, Suzuki, H, Fujiyoshi, Y.
Deposit date:2023-02-22
Release date:2023-08-30
Last modified:2023-12-06
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding.
Nat Commun, 14, 2023
8IA2
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BU of 8ia2 by Molmil
Structure of C5a bound human C5aR1 in complex with Go (Composite map)
Descriptor: Antibody fragment - ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ...
Authors:Yadav, M.K, Yadav, R, Maharana, J, Banerjee, R, Shukla, A.K, Gati, C.
Deposit date:2023-02-07
Release date:2023-10-18
Last modified:2023-11-08
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
7T8X
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BU of 7t8x by Molmil
Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state
Descriptor: ACETYLCHOLINE, Antibody fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Wang, Q, Du, Y, Kobilka, B.K.
Deposit date:2021-12-17
Release date:2023-01-25
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun, 14, 2023
8JXV
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BU of 8jxv by Molmil
Clozapine-bound H4R/Gi complex
Descriptor: 3-chloranyl-6-(4-methylpiperazin-1-yl)-11~{H}-benzo[b][1,4]benzodiazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:He, Y, Xia, R.
Deposit date:2023-07-01
Release date:2024-03-20
Last modified:2024-04-03
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor.
Nat Commun, 15, 2024
7VDL
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BU of 7vdl by Molmil
Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Li, Y, Yang, F.
Deposit date:2021-09-07
Release date:2021-12-01
Last modified:2022-07-20
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VUH
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BU of 7vuh by Molmil
Cryo-EM structure of a class A orphan GPCR
Descriptor: 3-chloranyl-N-[2-oxidanylidene-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Z.J, Hua, T, Zhou, Y.L, Wu, L.J.
Deposit date:2021-11-02
Release date:2021-12-29
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Molecular insights into ligand recognition and G protein coupling of the neuromodulatory orphan receptor GPR139.
Cell Res., 32, 2022
8JLK
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BU of 8jlk by Molmil
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
Descriptor: 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
7T96
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BU of 7t96 by Molmil
Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM
Descriptor: 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, J, Wang, Q, Du, Y, Kobilka, B.K.
Deposit date:2021-12-18
Release date:2023-01-25
Last modified:2024-02-07
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.
Nat Commun, 14, 2023
8HSC
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BU of 8hsc by Molmil
Gi bound Orphan GPR20 complex with Fab046 in ligand-free state
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Lin, X, Jiang, S, Xu, F.
Deposit date:2022-12-19
Release date:2023-03-08
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:The activation mechanism and antibody binding mode for orphan GPR20.
Cell Discov, 9, 2023
5TZY
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BU of 5tzy by Molmil
GPR40 in complex with AgoPAM AP8 and partial agonist MK-8666
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S,3R)-3-cyclopropyl-3-[(2R)-2-(1-{(1S)-1-[5-fluoro-2-(trifluoromethoxy)phenyl]ethyl}piperidin-4-yl)-3,4-dihydro-2H-1-benzopyran-7-yl]-2-methylpropanoic acid, (5aR,6S,6aS)-3-({2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl}methoxy)-5,5a,6,6a-tetrahydrocyclopropa[4,5]cyclopenta[1,2-c]pyridine-6-carboxylic acid, ...
Authors:Lu, J, Byrne, N, Patel, S, Sharma, S, Soisson, S.M.
Deposit date:2016-11-22
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Nat. Struct. Mol. Biol., 24, 2017
8F7Q
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BU of 8f7q by Molmil
Gi bound mu-opioid receptor in complex with beta-endorphin
Descriptor: Beta-endorphin, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Wang, Y, Zhuang, Y, DiBerto, J.F, Zhou, X.E, Schmitz, G.P, Yuan, Q, Jain, M.K, Liu, W, Melcher, K, Jiang, Y, Roth, B.L, Xu, H.E.
Deposit date:2022-11-20
Release date:2022-12-14
Last modified:2023-02-01
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Structures of the entire human opioid receptor family.
Cell, 186, 2023
7CKW
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BU of 7ckw by Molmil
Cryo-EM structure of Fenoldopam bound dopamine receptor DRD1-Gs signaling complex
Descriptor: (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ...
Authors:Yan, W, Shao, W.
Deposit date:2020-07-20
Release date:2021-03-03
Method:ELECTRON MICROSCOPY (3.22 Å)
Cite:Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes.
Cell, 184, 2021
8J19
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BU of 8j19 by Molmil
Cryo-EM structure of the LY237-bound GPR84 receptor-Gi complex
Descriptor: 6-nonylpyridine-2,4-diol, Antibody fragment ScFv16, G-protein coupled receptor 84, ...
Authors:Liu, H, Yin, W, Xu, H.E.
Deposit date:2023-04-12
Release date:2023-06-21
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.
Nat Commun, 14, 2023
8IJB
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BU of 8ijb by Molmil
Cryo-EM structure of human HCAR2-Gi complex with acipimox
Descriptor: 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Pan, X, Fang, Y.
Deposit date:2023-02-27
Release date:2024-01-03
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
8JLP
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BU of 8jlp by Molmil
Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex
Descriptor: 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide, Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
8J1A
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BU of 8j1a by Molmil
Cryo-EM structure of the GPR84 receptor-Gi complex with no ligand modeled
Descriptor: Antibody fragment ScFv16, G-protein coupled receptor 84, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Liu, H, Yin, W, Xu, H.E.
Deposit date:2023-04-12
Release date:2023-06-21
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural insights into ligand recognition and activation of the medium-chain fatty acid-sensing receptor GPR84.
Nat Commun, 14, 2023
8JLN
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BU of 8jln by Molmil
T1AM-bound hTAAR1-Gs protein complex
Descriptor: 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H.
Deposit date:2023-06-02
Release date:2023-11-15
Last modified:2024-01-03
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Ligand recognition and G-protein coupling of trace amine receptor TAAR1.
Nature, 624, 2023
7YAC
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BU of 7yac by Molmil
Paltusotine-bound SSTR2-Gi complex
Descriptor: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
Authors:Zhao, J, Shao, Z.
Deposit date:2022-06-27
Release date:2023-04-19
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Prospect of acromegaly therapy: molecular mechanism of clinical drugs octreotide and paltusotine.
Nat Commun, 14, 2023

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數據於2024-07-17公開中

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