6KNM

Apelin receptor in complex with single domain antibody

Summary for 6KNM

• Entry DOI: 10.2210/pdb6knm/pdb
• Descriptor: Apelin receptor,Rubredoxin,Apelin receptor, Single domain antibody JN241, ZINC ION (3 entities in total)
• Functional Keywords: gpcr, single-domain antibody, antagonist, agonist, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 60275.35

Authors

Ma, Y.B.,Ding, Y.,Song, X.,Ma, X.,Li, X.,Zhang, N.,Song, Y.,Sun, Y.,Shen, Y.,Zhong, W.,Hu, L.A.,Ma, Y.L.,Zhang, M.Y. (deposition date: 2019-08-06, release date: 2020-01-29, Last modification date: 2023-11-22)

• Primary citation: Ma, Y.,Ding, Y.,Song, X.,Ma, X.,Li, X.,Zhang, N.,Song, Y.,Sun, Y.,Shen, Y.,Zhong, W.,Hu, L.A.,Ma, Y.,Zhang, M.Y.; Structure-guided discovery of a single-domain antibody agonist against human apelin receptor.; Sci Adv, 6:eaax7379-eaax7379, 2020; PubMed: 31998837; DOI: 10.1126/sciadv.aax7379

Experimental method

X-RAY DIFFRACTION (3.2 Å)