6KNM

Apelin receptor in complex with single domain antibody

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004930	molecular_function	G protein-coupled receptor activity
B	0005506	molecular_function	iron ion binding
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0043448	biological_process	alkane catabolic process
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 1101

Chain	Residue
B	CYS1006
B	CYS1009
B	CYS1039
B	CYS1042

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	33
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGLGVSSTTVgFvvpftimltcyffiaqt.IAMK

Chain	Residue	Details
B	VAL199-LYS1002

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site_id	PS00202
Number of Residues	11
Details	RUBREDOXIN Rubredoxin signature. IpDDWvCPlCG

Chain	Residue	Details
B	ILE1033-GLY1043

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site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASAfCLTGLSFDRYLaI

Chain	Residue	Details
B	ALA115-ILE131

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	ILE31-PHE54

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site_id	SWS_FT_FI2
Number of Residues	29
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
B	ARG55-ALA64
B	ASP126-GLY146

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site_id	SWS_FT_FI3
Number of Residues	21
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	ASP65-ALA86

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site_id	SWS_FT_FI4
Number of Residues	63
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
B	THR87-THR99
B	MET165-GLU198
B	TYR271-ASN289

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site_id	SWS_FT_FI5
Number of Residues	25
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	PHE100-PHE125

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site_id	SWS_FT_FI6
Number of Residues	17
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	ALA147-VAL164

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site_id	SWS_FT_FI7
Number of Residues	24
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	VAL199-PHE223

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site_id	SWS_FT_FI8
Number of Residues	23
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	LEU247-LEU270

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site_id	SWS_FT_FI9
Number of Residues	22
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O

Chain	Residue	Details
B	ILE290-PHE312

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site_id	SWS_FT_FI10
Number of Residues	2
Details	SITE: Required for APELA and APLN/apelin-13 interaction and signaling => ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423

Chain	Residue	Details
B	TRP85
B	ARG168

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site_id	SWS_FT_FI11
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN15
B	ASN175

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site_id	SWS_FT_FI12
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00241, ECO:0000269|PubMed:10216292

Chain	Residue	Details
B	CYS1006
B	CYS1009
B	CYS1039
B	CYS1042

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site_id	SWS_FT_FI13
Number of Residues	1
Details	MOD_RES: N-formylmethionine => ECO:0000269|PubMed:1637309

Chain	Residue	Details
B	MET1001

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