6JN4
| Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor WL-001 | Descriptor: | ACETATE ION, ACETIC ACID, DI(HYDROXYETHYL)ETHER, ... | Authors: | Li, G.-B, Liu, S. | Deposit date: | 2019-03-13 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases. J.Med.Chem., 62, 2019
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6JN5
| Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor MS23 | Descriptor: | Serine Beta-Lactamase KPC-2, [(S)-(4-fluorophenyl)-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]methyl]boronic acid | Authors: | Li, G.-B, Liu, S. | Deposit date: | 2019-03-13 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases. J.Med.Chem., 62, 2019
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4IBR
| Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying G238S/E104K mutations | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, TEM-94 ES-beta-lactamase | Authors: | Dellus-Gur, E, Toth-Petroczy, A, Elias, M, Tawfik, D.S. | Deposit date: | 2012-12-09 | Release date: | 2013-04-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | What Makes a Protein Fold Amenable to Functional Innovation? Fold Polarity and Stability Trade-offs. J.Mol.Biol., 425, 2013
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1LI9
| Crystal structure of TEM-34 beta-Lactamase at 1.5 Angstrom | Descriptor: | Class A beta-Lactamase- TEM-34, PHOSPHATE ION, POTASSIUM ION | Authors: | Wang, X, Minasov, G, Shoichet, B.K. | Deposit date: | 2002-04-17 | Release date: | 2002-09-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34. J.Biol.Chem., 277, 2002
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6JN3
| Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor MS05 | Descriptor: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, Serine Beta-Lactamase KPC-2, ... | Authors: | Li, G.-B, Liu, S. | Deposit date: | 2019-03-13 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.216 Å) | Cite: | Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases. J.Med.Chem., 62, 2019
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4ID4
| Crystal structure of chimeric beta-lactamase cTEM-17m | Descriptor: | Beta-lactamase TEM, Beta-lactamase PSE-4, CHLORIDE ION, ... | Authors: | Park, J, Gobeil, S, Pelletier, J.N, Berghuis, A.M. | Deposit date: | 2012-12-11 | Release date: | 2013-12-25 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Maintenance of Native-like Protein Dynamics May Not Be Required for Engineering Functional Proteins. Chem.Biol., 21, 2014
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1HZO
| STRUCTURE OF CLASS A CEPHALOSPORINASE FROM PROTEUS VULGARIS K1 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BETA-LACTAMASE | Authors: | Nukaga, M, Crichlow, G.V, Kuzin, A.P, Mayama, K, Knox, J.R. | Deposit date: | 2001-01-25 | Release date: | 2002-04-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of an extended-spectrum class A beta-lactamase from Proteus vulgaris K1. J.Mol.Biol., 317, 2002
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1HTZ
| CRYSTAL STRUCTURE OF TEM52 BETA-LACTAMASE | Descriptor: | BETA-LACTAMASE MUTANT TEM52 | Authors: | Stevens, R.C, Orencia, M.C. | Deposit date: | 2001-01-03 | Release date: | 2001-03-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Predicting the emergence of antibiotic resistance by directed evolution and structural analysis. Nat.Struct.Biol., 8, 2001
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8EC4
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8EBI
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8ECF
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8EBR
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8DOD
| Beta-lactamase CTX-M-14 S130A | Descriptor: | Beta-lactamase, POTASSIUM ION | Authors: | Lu, S, Palzkill, T. | Deposit date: | 2022-07-12 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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8DOE
| Crystal Structure of CTX-M-14 N106A | Descriptor: | Beta-lactamase | Authors: | Lu, S, Palzkill, T. | Deposit date: | 2022-07-12 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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8DP4
| Beta-lactamase CTX-M-14 T235A | Descriptor: | Beta-lactamase | Authors: | Lu, S, Palzkill, T. | Deposit date: | 2022-07-14 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.402 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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8DON
| Beta-lactamase CTX-M-14 T215A | Descriptor: | Beta-lactamase, PHOSPHATE ION | Authors: | Lu, S, Palzkill, T. | Deposit date: | 2022-07-13 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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8DPQ
| Beta-lactamase CTX-M-14 N170A | Descriptor: | 1,2-ETHANEDIOL, Beta-lactamase | Authors: | Lu, S, Neetu, N, Palzkill, T. | Deposit date: | 2022-07-15 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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1LI0
| Crystal structure of TEM-32 beta-Lactamase at 1.6 Angstrom | Descriptor: | BICARBONATE ION, Class A beta-Lactamase- TEM-32, POTASSIUM ION | Authors: | Wang, X, Minasov, G, Shoichet, B.K. | Deposit date: | 2002-04-17 | Release date: | 2002-09-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | The structural bases of antibiotic resistance in the clinically derived mutant beta-lactamases TEM-30, TEM-32, and TEM-34. J.Biol.Chem., 277, 2002
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1N9B
| Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, BETA-LACTAMASE SHV-2, ... | Authors: | Nukaga, M, Mayama, K, Hujer, A.M, Bonomo, R.A, Knox, J.R. | Deposit date: | 2002-11-22 | Release date: | 2003-04-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Ultrahigh resolution structure of a class A beta-lactamase: On the mechanism and specificity of the extended-spectrum SHV-2 enzyme J.Mol.Biol., 328, 2003
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1FQG
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8ELA
| CTX-M-14 beta-lactamase mutant - N132A w MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-lactamase, CHLORIDE ION, ... | Authors: | Lu, S, Palzkill, T, Hu, L, Prasad, B.V.V. | Deposit date: | 2022-09-23 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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4JLF
| Inhibitor resistant (R220A) substitution in the Mycobacterium tuberculosis beta-lactamase | Descriptor: | Beta-lactamase, PHOSPHATE ION | Authors: | Hazra, S, Kurz, S, Blanchard, J, Bonomo, R. | Deposit date: | 2013-03-12 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Can inhibitor-resistant substitutions in the Mycobacterium tuberculosis beta-Lactamase BlaC lead to clavulanate resistance?: a biochemical rationale for the use of beta-lactam-beta-lactamase inhibitor combinations. Antimicrob.Agents Chemother., 57, 2013
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8ELB
| CTX-M-14 beta-lactamase mutant- N132A | Descriptor: | Beta-lactamase, DI(HYDROXYETHYL)ETHER | Authors: | Lu, S, Neetu, N, Palzkill, T. | Deposit date: | 2022-09-23 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Mutagenesis and structural analysis reveal the CTX-M beta-lactamase active site is optimized for cephalosporin catalysis and drug resistance. J.Biol.Chem., 299, 2023
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8EK9
| Crystal structure of the class A carbapenemase CRH-1 in complex with avibactam at 1.4 Angstrom resolution | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | Authors: | Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S. | Deposit date: | 2022-09-20 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases. Antimicrob.Agents Chemother., 67, 2023
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8EHU
| Crystal structure of the environmental CRH-1 class A carbapenemase at 1.1 Angstrom resolution | Descriptor: | Beta-lactamase | Authors: | Power, P, Brunetti, F, Ghiglione, B, Guardabassi, L, Gutkind, G, Klinke, S. | Deposit date: | 2022-09-14 | Release date: | 2023-05-31 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Biochemical and Structural Characterization of CRH-1, a Carbapenemase from Chromobacterium haemolyticum Related to KPC beta-Lactamases. Antimicrob.Agents Chemother., 67, 2023
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