6VHS

Crystal structure of CTX-M-14 in complex with beta-lactamase inhibitor ETX1317

Summary for 6VHS

• Entry DOI: 10.2210/pdb6vhs/pdb
• Descriptor: Beta-lactamase, (2R)-({[(3R,6S)-6-carbamoyl-1-formyl-4-methyl-1,2,3,6-tetrahydropyridin-3-yl]amino}oxy)(fluoro)acetic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ctx-m-14, beta-lactamase, b-lactamase, etx3517, etx-3517, avibactam, dbo, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 56992.36

Authors

Sacco, M.D.,Chen, Y. (deposition date: 2020-01-10, release date: 2020-08-26, Last modification date: 2023-10-11)

• Primary citation: Durand-Reville, T.F.,Comita-Prevoir, J.,Zhang, J.,Wu, X.,May-Dracka, T.L.,Romero, J.A.C.,Wu, F.,Chen, A.,Shapiro, A.B.,Carter, N.M.,McLeod, S.M.,Giacobbe, R.A.,Verheijen, J.C.,Lahiri, S.D.,Sacco, M.D.,Chen, Y.,O'Donnell, J.P.,Miller, A.A.,Mueller, J.P.,Tommasi, R.A.; Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine beta-Lactamases.; J.Med.Chem., 63:12511-12525, 2020; PubMed: 32658473; DOI: 10.1021/acs.jmedchem.0c00579

Experimental method

X-RAY DIFFRACTION (1.28 Å)