6UNB

Crystal structure of CTX-M-14 in complex with temocillin

Summary for 6UNB

• Entry DOI: 10.2210/pdb6unb/pdb
• Related: 6UN1 6UN3
• Descriptor: Beta-lactamase, (2R,4S)-2-[(1S)-1-{[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino}-1-methoxy-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4 -carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: temocillin, ticarcillin, b-lactam, lactam, penicillin, ctx-m-14 beta-lactamase, esbl, extended spectrum b-lactamase, hydrolase
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 57179.85

Authors

Sacco, M.,Chen, Y. (deposition date: 2019-10-11, release date: 2019-10-30, Last modification date: 2023-10-11)

• Primary citation: Sacco, M.D.,Kroeck, K.G.,Kemp, M.T.,Zhang, X.,Andrews, L.D.,Chen, Y.; Influence of the alpha-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 beta-Lactamase.; Antimicrob.Agents Chemother., 64:-, 2019; PubMed: 31685462; DOI: 10.1128/AAC.01473-19

Experimental method

X-RAY DIFFRACTION (1.3 Å)