6WEK
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![BU of 6wek by Molmil](/molmil-images/mine/6wek) | Structure of cGMP-bound WT TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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6WEL
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![BU of 6wel by Molmil](/molmil-images/mine/6wel) | Structure of cGMP-unbound F403V/V407A mutant TAX-4 reconstituted in lipid nanodiscs | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel, ... | Authors: | Zheng, X, Fu, Z, Su, D, Zhang, Y, Li, M, Pan, Y, Li, H, Li, S, Grassucci, R.A, Ren, Z, Hu, Z, Li, X, Zhou, M, Li, G, Frank, J, Yang, J. | Deposit date: | 2020-04-02 | Release date: | 2020-06-03 | Last modified: | 2020-07-22 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Mechanism of ligand activation of a eukaryotic cyclic nucleotide-gated channel. Nat.Struct.Mol.Biol., 27, 2020
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8T4M
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![BU of 8t4m by Molmil](/molmil-images/mine/8t4m) | Closed human HCN1 F186C S264C bound to cAMP, reconstituted in LMNG + SPL | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | Authors: | Burtscher, V, Mount, J, Cowgill, J, Chang, Y, Bickel, K, Yuan, P, Chanda, B. | Deposit date: | 2023-06-09 | Release date: | 2024-06-12 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural basis for hyperpolarization-dependent opening of human HCN1 channel. Nat Commun, 15, 2024
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8WCQ
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![BU of 8wcq by Molmil](/molmil-images/mine/8wcq) | Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in intermediate state | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHLORIDE ION, Proton-gated ion channel | Authors: | Bharambe, N, Li, Z, Basak, S. | Deposit date: | 2023-09-13 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nat Commun, 15, 2024
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8WCR
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![BU of 8wcr by Molmil](/molmil-images/mine/8wcr) | Cryo-EM structure of nanodisc (PE:PS:PC) reconstituted GLIC at pH 4 in open state | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHLORIDE ION, Proton-gated ion channel | Authors: | Bharambe, N, Li, Z, Basak, S. | Deposit date: | 2023-09-13 | Release date: | 2024-04-17 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nat Commun, 15, 2024
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8SIK
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![BU of 8sik by Molmil](/molmil-images/mine/8sik) | KCNQ1 with voltage sensor in the up conformation | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Mandala, V.S, MacKinnon, R. | Deposit date: | 2023-04-16 | Release date: | 2023-05-31 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel. Proc.Natl.Acad.Sci.USA, 120, 2023
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8SIM
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![BU of 8sim by Molmil](/molmil-images/mine/8sim) | KCNQ1 with voltage sensor in the intermediate conformation | Descriptor: | CALCIUM ION, Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Mandala, V.S, MacKinnon, R. | Deposit date: | 2023-04-16 | Release date: | 2023-05-31 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (6.2 Å) | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel. Proc.Natl.Acad.Sci.USA, 120, 2023
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8SIN
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![BU of 8sin by Molmil](/molmil-images/mine/8sin) | KCNQ1 with voltage sensor in the down conformation | Descriptor: | Calmodulin-1, Potassium voltage-gated channel subfamily KQT member 1 | Authors: | Mandala, V.S, MacKinnon, R. | Deposit date: | 2023-04-16 | Release date: | 2023-05-31 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (6.8 Å) | Cite: | The membrane electric field regulates the PIP 2 -binding site to gate the KCNQ1 channel. Proc.Natl.Acad.Sci.USA, 120, 2023
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7NP4
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![BU of 7np4 by Molmil](/molmil-images/mine/7np4) | cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Giese, H, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A. | Deposit date: | 2021-02-26 | Release date: | 2021-08-11 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81, 2021
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7E87
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![BU of 7e87 by Molmil](/molmil-images/mine/7e87) | |
7E8B
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![BU of 7e8b by Molmil](/molmil-images/mine/7e8b) | CryoEM structure of human Kv4.2-DPP6S complex | Descriptor: | Dipeptidyl aminopeptidase-like protein 6, Potassium voltage-gated channel subfamily D member 2 | Authors: | Kise, Y, Nureki, O. | Deposit date: | 2021-03-01 | Release date: | 2021-10-13 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis of gating modulation of Kv4 channel complexes. Nature, 599, 2021
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7BH1
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![BU of 7bh1 by Molmil](/molmil-images/mine/7bh1) | Cryo-EM Structure of KdpFABC in E1 state with K | Descriptor: | (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, POTASSIUM ION, Potassium-transporting ATPase ATP-binding subunit, ... | Authors: | Sweet, M.E, Larsen, C, Pedersen, B.P, Stokes, D.L. | Deposit date: | 2021-01-09 | Release date: | 2021-01-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.38 Å) | Cite: | Structural basis for potassium transport in prokaryotes by KdpFABC. Proc.Natl.Acad.Sci.USA, 118, 2021
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6WHG
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![BU of 6whg by Molmil](/molmil-images/mine/6whg) | PI3P and calcium bound full-length TRPY1 in detergent | Descriptor: | (2R)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1S,2S,3S,4S,5S,6R)-2,3,4,6-tetrahydroxy-5-(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-yl hexadecanoate, CALCIUM ION, Calcium channel YVC1 | Authors: | Ahmed, T, Moiseenkova-Bell, V.Y. | Deposit date: | 2020-04-08 | Release date: | 2021-04-21 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium. Structure, 30, 2022
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7BH2
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![BU of 7bh2 by Molmil](/molmil-images/mine/7bh2) | Cryo-EM Structure of KdpFABC in E2Pi state with BeF3 and K+ | Descriptor: | (2R)-3-(((2-aminoethoxy)(hydroxy)phosphoryl)oxy)-2-(palmitoyloxy)propyl (E)-octadec-9-enoate, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Sweet, M.E, Larsen, C, Pedersen, B.P, Stokes, D.L. | Deposit date: | 2021-01-09 | Release date: | 2021-01-27 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis for potassium transport in prokaryotes by KdpFABC. Proc.Natl.Acad.Sci.USA, 118, 2021
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3L9W
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![BU of 3l9w by Molmil](/molmil-images/mine/3l9w) | KefC C-terminal domain in complex with KefF and GSH | Descriptor: | ADENOSINE MONOPHOSPHATE, FLAVIN MONONUCLEOTIDE, GLUTATHIONE, ... | Authors: | Roosild, T.P. | Deposit date: | 2010-01-05 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Mechanism of ligand-gated potassium efflux in bacterial pathogens. Proc.Natl.Acad.Sci.USA, 107, 2010
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3BPZ
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![BU of 3bpz by Molmil](/molmil-images/mine/3bpz) | HCN2-I 443-460 E502K in the presence of cAMP | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Authors: | Craven, K.B, Olivier, N.B, Zagotta, W.N. | Deposit date: | 2007-12-19 | Release date: | 2008-03-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | C-terminal movement during gating in cyclic nucleotide-modulated channels. J.Biol.Chem., 283, 2008
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5J9P
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![BU of 5j9p by Molmil](/molmil-images/mine/5j9p) | KcsA in vitro | Descriptor: | Fab, POTASSIUM ION, pH-gated potassium channel KcsA | Authors: | Matulef, K, Valiyaveetil, F.I. | Deposit date: | 2016-04-10 | Release date: | 2016-07-20 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Combining in Vitro Folding with Cell Free Protein Synthesis for Membrane Protein Expression. Biochemistry, 55, 2016
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3L9X
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![BU of 3l9x by Molmil](/molmil-images/mine/3l9x) | KefC C-terminal domain in complex with KefF and ESG | Descriptor: | FLAVIN MONONUCLEOTIDE, Glutathione-regulated potassium-efflux system protein kefC, linker, ... | Authors: | Roosild, T.P. | Deposit date: | 2010-01-05 | Release date: | 2010-11-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Mechanism of ligand-gated potassium efflux in bacterial pathogens. Proc.Natl.Acad.Sci.USA, 107, 2010
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5MUO
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![BU of 5muo by Molmil](/molmil-images/mine/5muo) | X-ray structure of the 2-22' locally-closed mutant of GLIC in complex with propofol | Descriptor: | 2,6-BIS(1-METHYLETHYL)PHENOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Fourati, Z, Ruza, R.R, Delarue, M. | Deposit date: | 2017-01-13 | Release date: | 2018-02-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structural Basis for a Bimodal Allosteric Mechanism of General Anesthetic Modulation in Pentameric Ligand-Gated Ion Channels. Cell Rep, 23, 2018
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1U4E
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![BU of 1u4e by Molmil](/molmil-images/mine/1u4e) | Crystal Structure of Cytoplasmic Domains of GIRK1 channel | Descriptor: | G protein-activated inward rectifier potassium channel 1 | Authors: | Pegan, S, Arrabit, C, Zhou, W, Kwiatkowski, W, Slesinger, P.A, Choe, S. | Deposit date: | 2004-07-24 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification Nat.Neurosci., 8, 2005
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6JB3
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![BU of 6jb3 by Molmil](/molmil-images/mine/6jb3) | Structure of SUR1 subunit bound with repaglinide | Descriptor: | ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide | Authors: | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | Deposit date: | 2019-01-25 | Release date: | 2019-05-22 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel. Cell Rep, 27, 2019
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6O7C
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![BU of 6o7c by Molmil](/molmil-images/mine/6o7c) | |
1U4F
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![BU of 1u4f by Molmil](/molmil-images/mine/1u4f) | Crystal Structure of Cytoplasmic Domains of IRK1 (Kir2.1) channel | Descriptor: | Inward rectifier potassium channel 2 | Authors: | Pegan, S, Arrabit, C, Zhou, W, Kwiatkowski, W, Slesinger, P.A, Choe, S. | Deposit date: | 2004-07-24 | Release date: | 2005-03-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification Nat.Neurosci., 8, 2005
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7N17
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![BU of 7n17 by Molmil](/molmil-images/mine/7n17) | Structure of TAX-4_R421W apo open state | Descriptor: | 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Cyclic nucleotide-gated cation channel | Authors: | Zheng, X, Li, H, Hu, Z, Su, D, Yang, J. | Deposit date: | 2021-05-27 | Release date: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 2022
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7N15
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![BU of 7n15 by Molmil](/molmil-images/mine/7n15) | Structure of TAX-4_R421W w/cGMP open state | Descriptor: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CYCLIC GUANOSINE MONOPHOSPHATE, ... | Authors: | Zheng, X, Li, H, Hu, Z, Su, D, Yang, J. | Deposit date: | 2021-05-27 | Release date: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural and functional characterization of an achromatopsia-associated mutation in a phototransduction channel. Commun Biol, 5, 2022
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