7NP4

cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture

Summary for 7NP4

Entry DOI	10.2210/pdb7np4/pdb
EMDB information	12513
Descriptor	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
Functional Keywords	hcn channels, camp, ion transport, membrane protein
Biological source	Oryctolagus cuniculus (Rabbit) More
Total number of polymer chains	4
Total formula weight	395407.73
Authors	Giese, H.,Chaves-Sanjuan, A.,Saponaro, A.,Clarke, O.,Bolognesi, M.,Mancia, F.,Hendrickson, W.A.,Thiel, G.,Santoro, B.,Moroni, A. (deposition date: 2021-02-26, release date: 2021-08-11)
Primary citation	Saponaro, A.,Bauer, D.,Giese, M.H.,Swuec, P.,Porro, A.,Gasparri, F.,Sharifzadeh, A.S.,Chaves-Sanjuan, A.,Alberio, L.,Parisi, G.,Cerutti, G.,Clarke, O.B.,Hamacher, K.,Colecraft, H.M.,Mancia, F.,Hendrickson, W.A.,Siegelbaum, S.A.,DiFrancesco, D.,Bolognesi, M.,Thiel, G.,Santoro, B.,Moroni, A. Gating movements and ion permeation in HCN4 pacemaker channels. Mol.Cell, 81:2929-2943.e6, 2021 Cited by PubMed: 34166608 DOI: 10.1016/j.molcel.2021.05.033 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation