7NP4
cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005249 | molecular_function | voltage-gated potassium channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005249 | molecular_function | voltage-gated potassium channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005249 | molecular_function | voltage-gated potassium channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0055085 | biological_process | transmembrane transport |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005249 | molecular_function | voltage-gated potassium channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue CMP A 1001 |
| Chain | Residue |
| A | PHE659 |
| A | ILE715 |
| A | GLY660 |
| A | GLU661 |
| A | ILE662 |
| A | CYS663 |
| A | ARG670 |
| A | THR671 |
| A | ARG711 |
| A | ARG714 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue CMP B 1001 |
| Chain | Residue |
| B | PHE659 |
| B | GLY660 |
| B | GLU661 |
| B | ILE662 |
| B | CYS663 |
| B | ARG670 |
| B | THR671 |
| B | ARG711 |
| B | ARG714 |
| B | ILE715 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue CMP C 1001 |
| Chain | Residue |
| C | PHE659 |
| C | GLY660 |
| C | GLU661 |
| C | ILE662 |
| C | CYS663 |
| C | ARG670 |
| C | THR671 |
| C | ARG711 |
| C | ARG714 |
| C | ILE715 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue CMP D 1001 |
| Chain | Residue |
| D | PHE659 |
| D | GLY660 |
| D | GLU661 |
| D | ILE662 |
| D | CYS663 |
| D | ARG670 |
| D | THR671 |
| D | ARG711 |
| D | ARG714 |
| D | ILE715 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG |
| Chain | Residue | Details |
| A | ILE623-GLY639 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 112 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S1","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 148 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 92 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S2","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 56 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 88 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S3","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 140 |
| Details | Transmembrane: {"description":"Helical; Voltage-sensor; Name=Segment S4","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 120 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S5","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 112 |
| Details | Intramembrane: {"description":"Pore-forming; Name=Segment H5","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 128 |
| Details | Transmembrane: {"description":"Helical; Name=Segment S6","evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9Y3Q4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 24 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"34166608","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7NP4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
