7NP4

cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005249	molecular_function	voltage-gated potassium channel activity
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005216	molecular_function	monoatomic ion channel activity
B	0005249	molecular_function	voltage-gated potassium channel activity
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0055085	biological_process	transmembrane transport
C	0005216	molecular_function	monoatomic ion channel activity
C	0005249	molecular_function	voltage-gated potassium channel activity
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0055085	biological_process	transmembrane transport
D	0005216	molecular_function	monoatomic ion channel activity
D	0005249	molecular_function	voltage-gated potassium channel activity
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CMP A 1001

Chain	Residue
A	PHE659
A	ILE715
A	GLY660
A	GLU661
A	ILE662
A	CYS663
A	ARG670
A	THR671
A	ARG711
A	ARG714

---

site_id	AC2
Number of Residues	10
Details	binding site for residue CMP B 1001

Chain	Residue
B	PHE659
B	GLY660
B	GLU661
B	ILE662
B	CYS663
B	ARG670
B	THR671
B	ARG711
B	ARG714
B	ILE715

---

site_id	AC3
Number of Residues	10
Details	binding site for residue CMP C 1001

Chain	Residue
C	PHE659
C	GLY660
C	GLU661
C	ILE662
C	CYS663
C	ARG670
C	THR671
C	ARG711
C	ARG714
C	ILE715

---

site_id	AC4
Number of Residues	10
Details	binding site for residue CMP D 1001

Chain	Residue
D	PHE659
D	GLY660
D	GLU661
D	ILE662
D	CYS663
D	ARG670
D	THR671
D	ARG711
D	ARG714
D	ILE715

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGTiGKkMYFIqhG

Chain	Residue	Details
A	ILE623-GLY639

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1088
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-TYR259
D	MET1-TYR259
D	THR317-LEU329
D	ASP411-ALA413
A	THR317-LEU329
A	ASP411-ALA413
B	MET1-TYR259
B	THR317-LEU329
B	ASP411-ALA413
C	MET1-TYR259
C	THR317-LEU329
C	ASP411-ALA413

---

site_id	SWS_FT_FI2
Number of Residues	112
Details	TRANSMEM: Helical; Name=Segment S1 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	SER260-PHE288
B	SER260-PHE288
C	SER260-PHE288
D	SER260-PHE288

---

site_id	SWS_FT_FI3
Number of Residues	148
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	LYS289-ASN292
C	VAL353-ALA374
C	ASP445-ASP449
C	CYS479-MET488
D	LYS289-ASN292
D	VAL353-ALA374
D	ASP445-ASP449
D	CYS479-MET488
A	VAL353-ALA374
A	ASP445-ASP449
A	CYS479-MET488
B	LYS289-ASN292
B	VAL353-ALA374
B	ASP445-ASP449
B	CYS479-MET488
C	LYS289-ASN292

---

site_id	SWS_FT_FI4
Number of Residues	92
Details	TRANSMEM: Helical; Name=Segment S2 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	THR293-ARG316
B	THR293-ARG316
C	THR293-ARG316
D	THR293-ARG316

---

site_id	SWS_FT_FI5
Number of Residues	88
Details	TRANSMEM: Helical; Name=Segment S3 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	ASP330-PRO352
B	ASP330-PRO352
C	ASP330-PRO352
D	ASP330-PRO352

---

site_id	SWS_FT_FI6
Number of Residues	140
Details	TRANSMEM: Helical; Voltage-sensor; Name=Segment S4 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	LEU375-TYR410
B	LEU375-TYR410
C	LEU375-TYR410
D	LEU375-TYR410

---

site_id	SWS_FT_FI7
Number of Residues	120
Details	TRANSMEM: Helical; Name=Segment S5 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	SER414-GLN444
B	SER414-GLN444
C	SER414-GLN444
D	SER414-GLN444

---

site_id	SWS_FT_FI8
Number of Residues	112
Details	INTRAMEM: Pore-forming; Name=Segment H5 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	CYS450-LEU478
B	CYS450-LEU478
C	CYS450-LEU478
D	CYS450-LEU478

---

site_id	SWS_FT_FI9
Number of Residues	128
Details	TRANSMEM: Helical; Name=Segment S6 => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	GLY489-LEU521
B	GLY489-LEU521
C	GLY489-LEU521
D	GLY489-LEU521

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9Y3Q4

Chain	Residue	Details
A	TYR560
B	ARG711
C	TYR560
C	LYS563
C	PHE565
C	GLU567
C	ARG711
D	TYR560
D	LYS563
D	PHE565
D	GLU567
A	LYS563
D	ARG711
A	PHE565
A	GLU567
A	ARG711
B	TYR560
B	LYS563
B	PHE565
B	GLU567

---

site_id	SWS_FT_FI11
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269|PubMed:34166608, ECO:0007744|PDB:7NP4

Chain	Residue	Details
A	GLY660
B	ARG670
B	THR671
B	VAL674
C	GLY660
C	GLU661
C	CYS663
C	ARG670
C	THR671
C	VAL674
D	GLY660
A	GLU661
D	GLU661
D	CYS663
D	ARG670
D	THR671
D	VAL674
A	CYS663
A	ARG670
A	THR671
A	VAL674
B	GLY660
B	GLU661
B	CYS663

---

site_id	SWS_FT_FI12
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9JKA7

Chain	Residue	Details
A	SER145
B	SER145
C	SER145
D	SER145

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O70507

Chain	Residue	Details
A	SER806
A	SER810
B	SER806
B	SER810
C	SER806
C	SER810
D	SER806
D	SER810

---