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4WFX	Coxsackievirus B3 Polymerase - F232L Mutant - NaCl Crystal Form Descriptor: RNA-directed RNA polymerase, SODIUM ION Authors: Peersen, O.B, McDonald, S.M. Deposit date: 2014-09-17 Release date: 2014-10-22 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.808 Å) Cite: Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases. J.Virol., 89, 2015
7ZX8	Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (OC) Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. Deposit date: 2022-05-20 Release date: 2022-12-07 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
7ZWD	Structure of SNAPc containing Pol II pre-initiation complex bound to U5 snRNA promoter (CC) Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. Deposit date: 2022-05-19 Release date: 2022-11-30 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3 Å) Cite: Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
7ZX7	Structure of SNAPc containing Pol II pre-initiation complex bound to U1 snRNA promoter (CC) Descriptor: DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB3, ... Authors: Rengachari, S, Schilbach, S, Kaliyappan, T, Gouge, J, Zumer, K, Schwarz, J, Urlaub, H, Dienemann, C, Vannini, A, Cramer, P. Deposit date: 2022-05-20 Release date: 2022-11-30 Last modified: 2024-07-24 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nat.Struct.Mol.Biol., 29, 2022
2F8E	Foot and Mouth Disease Virus RNA-dependent RNA polymerase in complex with uridylylated VPg protein Descriptor: MAGNESIUM ION, MANGANESE (II) ION, RNA-dependent RNA polymerase, ... Authors: Ferrer-Orta, C, Arias, A, Perez-Luque, R, Escarmis, C, Domingo, E, Verdaguer, N. Deposit date: 2005-12-02 Release date: 2006-03-28 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.9 Å) Cite: The structure of a protein primer-polymerase complex in the initiation of genome replication Embo J., 25, 2006
2IJF	Crystal Structure of the Poliovirus RNA-Dependent RNA Polymerase Fidelity Mutant 3Dpol G64S Descriptor: RNA-directed RNA polymerase Authors: Marcotte, L.L, Gohara, D.G, Filman, D.J, Hogle, J.M. Deposit date: 2006-09-29 Release date: 2007-02-13 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3 Å) Cite: Crystal structure of poliovirus 3CD: virally-encoded protease and precursor to the RNA-dependent RNA polymerase. J.Virol., 81, 2007
1HHS	RNA dependent RNA polymerase from dsRNA bacteriophage phi6 Descriptor: MANGANESE (II) ION, RNA-DIRECTED RNA POLYMERASE Authors: Grimes, J.M, Butcher, S.J, Makeyev, E.V, Bamford, D.H, Stuart, D.I. Deposit date: 2000-12-28 Release date: 2001-03-27 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2 Å) Cite: A Mechanism for Initiating RNA-Dependent RNA Polymerization Nature, 410, 2001
2PI4	T7RNAP complexed with a phi10 protein and initiating GTPs. Descriptor: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 5'-D(*CP*TP*TP*CP*CP*TP*AP*TP*AP*GP*TP*GP*AP*GP*TP*CP*GP*TP*AP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*CP*GP*AP*CP*TP*CP*AP*CP*T)-3', ... Authors: Kennedy, W.P, Momand, J.R, Yin, Y.W. Deposit date: 2007-04-12 Release date: 2007-06-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase. J.Mol.Biol., 370, 2007
1S77	T7 RNAP product pyrophosphate elongation complex Descriptor: DNA (5'-D(*GP*CP*CP*GP*TP*GP*CP*GP*CP*AP*TP*TP*CP*GP*CP*CP*GP*TP*GP*TP*T)-3'), DNA (5'-D(*TP*TP*TP*AP*CP*GP*TP*TP*GP*CP*GP*CP*AP*CP*GP*GP*C)-3'), DNA-directed RNA polymerase, ... Authors: Yin, Y.W, Steitz, T.A. Deposit date: 2004-01-29 Release date: 2004-03-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.69 Å) Cite: The structural mechanism of translocation and helicase activity in T7 RNA polymerase. Cell(Cambridge,Mass.), 116, 2004
2RLU	The Three Dimensional Structure of the Moorella thermoacetica Selenocysteine Insertion Sequence RNA Hairpin and its Interaction with the Elongation factor SelB Descriptor: RNA (5'-R(*GP*GP*UP*UP*GP*CP*GP*GP*GP*UP*CP*UP*CP*GP*CP*AP*AP*CP*C)-3') Authors: Beribisky, A.V, Tavares, T.J, Amborski, A.N, Motamed, M, Johnson, A.E, Mark, T.L, Johnson, P.E. Deposit date: 2007-08-21 Release date: 2008-02-26 Last modified: 2024-05-01 Method: SOLUTION NMR Cite: The three-dimensional structure of the Moorella thermoacetica selenocysteine insertion sequence RNA hairpin and its interaction with the elongation factor SelB Rna, 13, 2007
6EEC	Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3 promoter captured by Corallopyronin Descriptor: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-13 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY (3.55 Å) Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6EDT	Mycobacterium tuberculosis RNAP open promoter complex with RbpA/CarD and AP3 promoter Descriptor: DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J. Deposit date: 2018-08-10 Release date: 2018-11-21 Last modified: 2024-03-13 Method: ELECTRON MICROSCOPY Cite: Structures of an RNA polymerase promoter melting intermediate elucidate DNA unwinding. Nature, 565, 2019
6LD2	Zika NS5 polymerase domain Descriptor: (1S,2S,4S,5R)-2,4-dimethoxy-5-thiophen-2-yl-cyclohexane-1-carboxylic acid, RNA-directed RNA polymerase NS5, ZINC ION Authors: El Sahili, A, Lescar, J. Deposit date: 2019-11-20 Release date: 2020-08-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD1	Zika NS5 polymerase domain Descriptor: 1,2-ETHANEDIOL, RNA-directed RNA polymerase NS5, ZINC ION Authors: El Sahili, A, Lescar, J. Deposit date: 2019-11-20 Release date: 2020-08-12 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD5	Zika NS5 polymerase domain Descriptor: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... Authors: El Sahili, A, Lescar, J. Deposit date: 2019-11-20 Release date: 2020-08-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.94 Å) Cite: Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD4	Zika NS5 polymerase domain Descriptor: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, 3-methoxybenzenesulfonamide, RNA-directed RNA polymerase NS5, ... Authors: El Sahili, A, Lescar, J. Deposit date: 2019-11-20 Release date: 2020-08-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6LD3	Zika NS5 polymerase domain Descriptor: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... Authors: El Sahili, A, Lescar, J. Deposit date: 2019-11-20 Release date: 2020-08-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6KWQ	Crystal structure of enterovirus 71 polymerase elongation complex (native form) Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... Authors: Shi, W, Gong, P. Deposit date: 2019-09-08 Release date: 2019-12-11 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.76 Å) Cite: A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
8IIB	Crystal structure of Israeli acute paralysis virus RNA-dependent RNA polymerase delta85 mutant (residues 86-546) Descriptor: CADMIUM ION, CHLORIDE ION, MAGNESIUM ION, ... Authors: Fang, X, Lu, G, Hou, C, Gong, P. Deposit date: 2023-02-24 Release date: 2023-06-07 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (2.69 Å) Cite: Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding. Virol Sin, 38, 2023
5IEM	NMR structure of the 5'-terminal hairpin of the 7SK snRNA Descriptor: 7SK snRNA Authors: Bourbigot, S, Dock-Bregeon, A.C, Coutant, J, Kieffer, B, Lebars, I. Deposit date: 2016-02-25 Release date: 2016-11-02 Last modified: 2024-06-19 Method: SOLUTION NMR Cite: Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA. RNA, 22, 2016
8PM0	Influenza A/H7N9 polymerase in replicase-like conformation in pre-initiation state with Pol II pS5 CTD peptide mimic bound in site 1A/2A Descriptor: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... Authors: Arragain, B, Cusack, S. Deposit date: 2023-06-27 Release date: 2024-02-21 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
4WFY	Coxsackievirus B3 Polymerase - F232L Mutant - AmSO4 Crystal Form Descriptor: GLYCEROL, RNA-directed RNA polymerase, SULFATE ION Authors: Peersen, O.B, McDonald, S.M. Deposit date: 2014-09-17 Release date: 2014-10-22 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Structure-Function Relationships Underlying the Replication Fidelity of Viral RNA-Dependent RNA Polymerases. J.Virol., 89, 2015
4X2B	K20A RNA dependent RNA polymerase mutant from Foot-and-Mouth disease Virus complexed with an RNA Descriptor: MAGNESIUM ION, RNA dependent RNA polymerase, RNA primer, ... Authors: Verdaguer, N, Ferrer-Orta, C. Deposit date: 2014-11-26 Release date: 2015-05-06 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (2.94 Å) Cite: Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition. J.Virol., 89, 2015
6VVZ	Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with Sorangicin Descriptor: DNA (62-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. Deposit date: 2020-02-18 Release date: 2020-10-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.72 Å) Cite: The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
6VVX	Mycobacterium tuberculosis WT RNAP transcription initiation intermediate structure with Sorangicin Descriptor: DNA (63-MER), DNA (65-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Lilic, M, Boyaci, H, Chen, J, Campbell, E.A, Darst, S.A. Deposit date: 2020-02-18 Release date: 2020-10-21 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.39 Å) Cite: The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020

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