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7M52	B6 Fab fragment bound to the HKU4 spike stem helix peptide Descriptor: B6 antigen-binding (Fab) fragment heavy chain, B6 antigen-binding (Fab) fragment light chain, GLYCEROL, ... Authors: Sauer, M.M, Park, Y.J, Veesler, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID) Deposit date: 2021-03-22 Release date: 2021-05-26 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural basis for broad coronavirus neutralization. Nat.Struct.Mol.Biol., 28, 2021
1IGC	IGG1 FAB FRAGMENT (MOPC21) COMPLEX WITH DOMAIN III OF PROTEIN G FROM STREPTOCOCCUS Descriptor: IGG1-KAPPA MOPC21 FAB (HEAVY CHAIN), IGG1-KAPPA MOPC21 FAB (LIGHT CHAIN), STREPTOCOCCAL PROTEIN G (DOMAIN III) Authors: Derrick, J.P, Wigley, D.B. Deposit date: 1994-08-05 Release date: 1995-06-03 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.6 Å) Cite: The third IgG-binding domain from streptococcal protein G. An analysis by X-ray crystallography of the structure alone and in a complex with Fab. J.Mol.Biol., 243, 1994
6PXH	Crystal Structure of MERS-CoV S1-NTD bound with G2 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DIHYDROFOLIC ACID, ... Authors: Wang, N, McLellan, J.S. Deposit date: 2019-07-26 Release date: 2019-09-25 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD. Cell Rep, 28, 2019
4KRP	Nanobody/VHH domain 9G8 in complex with the extracellular region of EGFR Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab heavy chain, ... Authors: Ferguson, K.M, Schmitz, K.R. Deposit date: 2013-05-16 Release date: 2013-08-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.823 Å) Cite: Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains. Structure, 21, 2013
4KRL	Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 6.0 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Ferguson, K.M, Schmitz, K.R. Deposit date: 2013-05-16 Release date: 2013-08-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.849 Å) Cite: Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains. Structure, 21, 2013
4KRO	Nanobody/VHH domain EgA1 in complex with the extracellular region of EGFR Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab heavy chain, ... Authors: Ferguson, K.M, Schmitz, K.R. Deposit date: 2013-05-16 Release date: 2013-08-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (3.054 Å) Cite: Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains. Structure, 21, 2013
4KRM	Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Epidermal growth factor receptor, ... Authors: Ferguson, K.M, Schmitz, K.R. Deposit date: 2013-05-16 Release date: 2013-08-28 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.655 Å) Cite: Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains. Structure, 21, 2013
5XAJ	Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex. Descriptor: Fab E1 heavy chain, Fab E1 light chain, FabHM14c10 heavy chain, ... Authors: Wong, Y.H, Goh, B.C, Lescar, J. Deposit date: 2017-03-13 Release date: 2017-06-14 Last modified: 2017-07-19 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural mimicry of the dengue virus envelope glycoprotein revealed by the crystallographic study of an idiotype-anti-idiotype Fab complex J. Virol., 2017
8W0Q	Pembrolizumab CDR-H3 Loop Mimic Descriptor: Pembrolizumab CDR-H3 Loop Mimic Authors: Feig, M, Roche, S.P. Deposit date: 2024-02-14 Release date: 2024-07-03 Last modified: 2024-07-31 Method: SOLUTION NMR Cite: De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics. Acs Chem.Biol., 19, 2024
3O2V	Crystal structure of 1E9 PheL89Ser/LeuH47Trp/MetH100bPhe, an engineered Diels-Alderase Fab with modified specificity and catalytic activity Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CITRATE ANION, Chimeric antibody Fab 1E9, ... Authors: Verdino, P, Wilson, I.A. Deposit date: 2010-07-22 Release date: 2011-07-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal structure of 1E9 PheL89Ser/LeuH47Trp/MetH100bPhe, an engineered Diels-Alderase Fab with modified specificity and catalytic activity To be Published
9IJD	Carazolol-activated human beta3 adrenergic receptor Descriptor: (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol, Beta-3 adrenergic receptor, Camelid antibody VHH fragment, ... Authors: Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X. Deposit date: 2024-06-22 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (2.76 Å) Cite: Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker. Chempluschem, 2024
9IJE	Epinephrine-activated human beta3 adrenergic receptor Descriptor: Beta-3 adrenergic receptor, Camelid antibody VHH fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Zheng, S, Zhang, S, Dai, S, Chen, K, Gao, K, Lin, B, Liu, X. Deposit date: 2024-06-22 Release date: 2024-08-21 Method: ELECTRON MICROSCOPY (2.34 Å) Cite: Molecular Mechanism of the beta 3AR Agonist Activity of a beta-Blocker. Chempluschem, 2024
4X98	Immunoglobulin Fc heterodimer variant Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region Authors: Seok, S.H, Choi, H.J, Kim, Y.J, Seo, M.D, Kim, Y.S. Deposit date: 2014-12-11 Release date: 2015-06-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.499 Å) Cite: Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation. Mol.Immunol., 65, 2015
4X99	Immunoglobulin Fc heterodimers variant Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region Authors: Seok, S.H, Choi, H.J, Kim, Y.J, Seo, M.D, Kim, Y.S. Deposit date: 2014-12-11 Release date: 2015-06-03 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.498 Å) Cite: Crystal structures of immunoglobulin Fc heterodimers reveal the molecular basis for heterodimer formation. Mol.Immunol., 65, 2015
7F7E	SARS-CoV-2 S protein RBD in complex with A5-10 Fab Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of A5-10 Fab, Light chain of A5-10 Fab, ... Authors: Dou, Y, Wang, X, Wang, K, Liu, P, Lu, B. Deposit date: 2021-06-29 Release date: 2022-02-02 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants. Emerg Microbes Infect, 11, 2022
5VEB	Crystal structure of a Fab binding to extracellular domain 5 of Cadherin-6 Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, Cadherin-6, anti-CDH6 Fab heavy chain, ... Authors: Zhu, X, Bialucha, C.U, London, A, Clark, K, Hu, T. Deposit date: 2017-04-04 Release date: 2017-06-07 Last modified: 2024-04-24 Method: X-RAY DIFFRACTION (2.34 Å) Cite: Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer Discov, 7, 2017
6DZY	Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine Descriptor: (5beta)-12-methoxyibogamine, 15B8 antibody heavy chain, 15B8 antibody light chain, ... Authors: Coleman, J.A, Yang, D, Gouaux, E. Deposit date: 2018-07-05 Release date: 2019-04-24 Last modified: 2020-07-29 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569, 2019
8JF7	Triheteromeric NMDA receptor GluN1-GluN2A-GluN3A in complex with glycine, glutamate, a GluN1-specific Fab,and a GluN2A-specific Fab Descriptor: GluN1-specific antibody fragment heavy chain, GluN1-specific antibody fragment light chain, GluN2A-specific antibody fragment heavy chain, ... Authors: Kou, Z, Zhu, S. Deposit date: 2023-05-17 Release date: 2024-05-22 Method: ELECTRON MICROSCOPY (7.73 Å) Cite: Probing the architecture of native GluN1-N2-N3A NMDA receptors by cryo-EM and click chemistry. To Be Published
8DY5	Crystal Structure of spFv CAT2200 LH in complex with IL-17A Descriptor: CALCIUM ION, CHLORIDE ION, Interleukin-17A, ... Authors: Luo, J, Boucher, L.E. Deposit date: 2022-08-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.2 Å) Cite: "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15, 2023
8DY1	Crystal Structure of scFv CAT2200 LH in complex with IL-17A Descriptor: Interleukin-17A, SULFATE ION, scFv CAT2200 LH Authors: Luo, J, Armstrong, A.A. Deposit date: 2022-08-03 Release date: 2023-05-03 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.68 Å) Cite: "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15, 2023
4HMG	REFINEMENT OF THE INFLUENZA VIRUS HEMAGGLUTININ BY SIMULATED ANNEALING Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEMAGGLUTININ, CHAIN HA1, ... Authors: Weis, W.I, Bruenger, A.T, Skehel, J.J, Wiley, D.C. Deposit date: 1989-09-11 Release date: 1991-01-15 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (3 Å) Cite: Refinement of the influenza virus hemagglutinin by simulated annealing. J.Mol.Biol., 212, 1990
3LD8	Structure of JMJD6 and Fab Fragments Descriptor: Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6, FE (III) ION, GLYCEROL, ... Authors: Hong, X, Zang, J, White, J, Kappler, J.W, Wang, C, Zhang, G. Deposit date: 2010-01-12 Release date: 2010-08-04 Last modified: 2012-06-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Interaction of JMJD6 with single-stranded RNA. Proc.Natl.Acad.Sci.USA, 107, 2010
6P9O	Poliovirus 135S-like expanded particle in complex with a monoclonal antibody directed against the N-terminal extension of capsid protein VP1 Descriptor: VP1, VP2, VP3 Authors: Hogle, J.M, Filman, D.J, Shah, P.N.M. Deposit date: 2019-06-10 Release date: 2020-06-10 Last modified: 2020-10-21 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Cryo-EM structures reveal two distinct conformational states in a picornavirus cell entry intermediate. Plos Pathog., 16, 2020
6JBP	Structure of MP-4 from Mucuna pruriens at 2.22 Angstroms Descriptor: Kunitz-type trypsin inhibitor-like 2 protein Authors: Jain, A, Shikhi, M, Kumar, A, Kumar, A, Nair, D.T, Salunke, D.M. Deposit date: 2019-01-26 Release date: 2020-01-29 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.217 Å) Cite: The structure of MP-4 from Mucuna pruriens at 2.22 angstrom resolution. Acta Crystallogr.,Sect.F, 76, 2020
6CCB	Crystal structure of 253-11 SOSIP trimer in complex with 10-1074 Fab Descriptor: 10-1074 FAB heavy chain, 10-1074 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Moyo, T, Ereno-Orbea, J, Dorfman, J, Julien, J.P. Deposit date: 2018-02-06 Release date: 2018-04-04 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (6.5 Å) Cite: Molecular Basis of Unusually High Neutralization Resistance in Tier 3 HIV-1 Strain 253-11. J. Virol., 92, 2018

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