8DY5

Crystal Structure of spFv CAT2200 LH in complex with IL-17A

Summary for 8DY5

Entry DOI	10.2210/pdb8dy5/pdb
Descriptor	spFv CAT2200 LH, Interleukin-17A, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	scfv, stapled scfv, spfv, germline scfv, single chain fv, scfv stabilizations, antibody, immune system, antibody antigen complex
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	81562.24
Authors	Luo, J.,Boucher, L.E. (deposition date: 2022-08-03, release date: 2023-05-03, Last modification date: 2023-10-25)
Primary citation	Boucher, L.E.,Prinslow, E.G.,Feldkamp, M.,Yi, F.,Nanjunda, R.,Wu, S.J.,Liu, T.,Lacy, E.R.,Jacobs, S.,Kozlyuk, N.,Del Rosario, B.,Wu, B.,Aquino, P.,Davidson, R.C.,Heyne, S.,Mazzanti, N.,Testa, J.,Diem, M.D.,Gorre, E.,Mahan, A.,Nanda, H.,Gunawardena, H.P.,Gervais, A.,Armstrong, A.A.,Teplyakov, A.,Huang, C.,Zwolak, A.,Chowdhury, P.,Cheung, W.C.,Luo, J. "Stapling" scFv for multispecific biotherapeutics of superior properties. Mabs, 15:2195517-2195517, 2023 Cited by PubMed: 37074212 DOI: 10.1080/19420862.2023.2195517 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation