6DZY
Cryo-EM structure of the ts2-active human serotonin transporter in complex with 15B8 Fab and 8B6 ScFv bound to ibogaine
Summary for 6DZY
| Entry DOI | 10.2210/pdb6dzy/pdb |
| EMDB information | 8942 |
| Descriptor | Sodium-dependent serotonin transporter, 15B8 antibody heavy chain, 15B8 antibody light chain, ... (7 entities in total) |
| Functional Keywords | ibogaine, human serotonin transporter, fab, transport protein-immune system complex, transport protein/immune system |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 112779.95 |
| Authors | Coleman, J.A.,Yang, D.,Gouaux, E. (deposition date: 2018-07-05, release date: 2019-04-24, Last modification date: 2020-07-29) |
| Primary citation | Coleman, J.A.,Yang, D.,Zhao, Z.,Wen, P.C.,Yoshioka, C.,Tajkhorshid, E.,Gouaux, E. Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport. Nature, 569:141-145, 2019 Cited by PubMed: 31019304DOI: 10.1038/s41586-019-1135-1 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (4.1 Å) |
Structure validation
Download full validation report
