4KRM

Nanobody/VHH domain 7D12 in complex with domain III of the extracellular region of EGFR, pH 3.5

Summary for 4KRM

Entry DOI	10.2210/pdb4krm/pdb
Related	4KRL 4KRN 4KRO 4KRP
Descriptor	Epidermal growth factor receptor, Nanobody/VHH domain 7D12, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	cell surface receptor, glycoprotein, nanobody, vhh domain, camelid vh domain, antibody, antigen, antibody complex, transferase-immune system complex, transferase/immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	237521.82
Authors	Ferguson, K.M.,Schmitz, K.R. (deposition date: 2013-05-16, release date: 2013-08-28, Last modification date: 2023-09-20)
Primary citation	Schmitz, K.R.,Bagchi, A.,Roovers, R.C.,van Bergen En Henegouwen, P.M.P.,Ferguson, K.M. Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains. Structure, 21:1214-1224, 2013 Cited by PubMed: 23791944 DOI: 10.1016/j.str.2013.05.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.655 Å)

Structure validation